IGLL1 information

IGLL1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2H32, 2H3N, 2LKQ
Identifiers
Aliases	IGLL1, 14.1, AGM2, CD179b, IGL1, IGL5, IGLJ14.1, IGLL, IGO, IGVPB, VPREB2, immunoglobulin lambda like polypeptide 1
External IDs	OMIM: 146770; MGI: 96529; HomoloGene: 131669; GeneCards: IGLL1; OMA:IGLL1 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	23,580,302 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	16,681,849 bp
RNA expression pattern
	Top expressed in
	bone marrow; ; bone marrow cells; ; testicle; ; left testis; ; right testis; ; trabecular bone; ; thymus; ; monocyte; ; lymph node; ; spleen;
	Top expressed in
	bone marrow; ; granulocyte; ; embryo; ; choroid plexus; ; brown adipose tissue; ; choroid plexus of fourth ventricle; ; Region I of hippocampus proper; ; inferior colliculus; ; secondary oocyte; ; CA3 field;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	immunoglobulin receptor binding; antigen binding;
Cellular component	blood microparticle; membrane; external side of plasma membrane; immunoglobulin complex, circulating; extracellular region;
Biological process	B cell receptor signaling pathway; phagocytosis, recognition; positive regulation of B cell activation; phagocytosis, engulfment; innate immune response; defense response to bacterium; immune response; complement activation, classical pathway; leukocyte migration;
	Sources:Amigo / QuickGO
Orthologs
	3543
	16136
	ENSG00000128322
	ENSMUSG00000075370
	P15814
	P20764
	NM_020070; NM_152855; NM_001369906
	NM_001190325
	NP_064455; NP_690594; NP_001356835
	NP_001177254
	Wikidata
View/Edit Human	View/Edit Mouse

Immunoglobulin lambda-like polypeptide 1 is a protein that in humans is encoded by the IGLL1 gene.^[5]^[6]^[7] IGLL1 has also recently been designated CD179B (cluster of differentiation 179B).

It is associated with agammaglobulinemia-2.

The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants encoding different isoforms have been found for this gene.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000128322 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000075370 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bauer SR, Huebner K, Budarf M, Finan J, Erikson J, Emanuel BS, Nowell PC, Croce CM, Melchers F (Nov 1988). "The human Vpre B gene is located on chromosome 22 near a cluster of V lambda gene segments". Immunogenetics. 28 (5): 328–33. doi:10.1007/BF00364231. PMID 3139558. S2CID 6981867.
^ Schiff C, Milili M, Fougereau M (Dec 1989). "Isolation of early immunoglobulin lambda-like gene transcripts in human fetal liver". Eur J Immunol. 19 (10): 1873–8. doi:10.1002/eji.1830191018. PMID 2511029. S2CID 84544002.
^ ^a ^b "Entrez Gene: IGLL1 immunoglobulin lambda-like polypeptide 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000128322 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000075370 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid3139558-5] Bauer SR, Huebner K, Budarf M, Finan J, Erikson J, Emanuel BS, Nowell PC, Croce CM, Melchers F (Nov 1988). "The human Vpre B gene is located on chromosome 22 near a cluster of V lambda gene segments". Immunogenetics. 28 (5): 328–33. doi:10.1007/BF00364231. PMID 3139558. S2CID 6981867.

[pmid2511029-6] Schiff C, Milili M, Fougereau M (Dec 1989). "Isolation of early immunoglobulin lambda-like gene transcripts in human fetal liver". Eur J Immunol. 19 (10): 1873–8. doi:10.1002/eji.1830191018. PMID 2511029. S2CID 84544002.

[entrez-7] "Entrez Gene: IGLL1 immunoglobulin lambda-like polypeptide 1".

IGLL1 information

and 6 Related for: IGLL1 information

IGLL1

Hypogammaglobulinemia

List of human clusters of differentiation

C11orf42

Outline of immunology

List of OMIM disorder codes