Crystallographic structure of P-selectin lectin bound to sugar, shown in sticks.[1]
Identifiers
Symbol
Selectin
InterPro
IPR002396
Membranome
12
The selectins (cluster of differentiation 62 or CD62) are a family of cell adhesion molecules (or CAMs). All selectins are single-chain transmembrane glycoproteins that share similar properties to C-type lectins due to a related amino terminus and calcium-dependent binding.[2] Selectins bind to sugar moieties and so are considered to be a type of lectin, cell adhesion proteins that bind sugar polymers.[3]
^PDB: 1G1R; Somers WS, Tang J, Shaw GD, Camphausen RT (October 2000). "Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1". Cell. 103 (3): 467–79. doi:10.1016/S0092-8674(00)00138-0. PMID 11081633. S2CID 12719907.
^Cotran; Kumar, Collins (1998). Robbins Pathologic Basis of Disease. Philadelphia: W.B Saunders Company. ISBN 978-0-7216-7335-6.
^Parham, Peter (2005). The immune system (2nd ed.). New York: Garland Science. pp. 244–245. ISBN 978-0-8153-4093-5.
The selectins (cluster of differentiation 62 or CD62) are a family of cell adhesion molecules (or CAMs). All selectins are single-chain transmembrane glycoproteins...
presenting pre-formed P-selectins on the endothelial cell surface. P-selectins bind PSGL-1 as a ligand. E-selectins: E-selectin is expressed on activated...
adhesion molecules ICAM-1, VCAM-1, E-selectin and P-selectin (distinguished as sICAM-1, sVCAM-1, sE-selectin and sP-selectin). The cellular expression of CAMs...
selectin is limited to leukocyte collaborations with vascular endothelium. There are three types of selectins found in humans; L-selectin, P-selectin...
sialofucosylations rendering the selectin-binding glycoform of CD44 called HCELL (for Hematopoietic Cell E-selectin/L-selectin Ligand). (see below) Transcripts...
This is a list of astronauts by year of selection: people selected to train for a human spaceflight program to command, pilot, or serve as a crew member...
are E-selectin (endothelial), L-selectin (leukocyte), and P-selectin (platelet). The best-characterized ligand for the three selectins is P-selectin glycoprotein...
has indeed been observed for interactions of P-selectin with PSGL-1 or anti-P-selectin antibody, L-selectin with PSGL-1, myosin with actin, integrin alpha...
sialofucosylated glycoforms serve as functional colon carcinoma L-selectin and E-selectin ligands, which may be critical to the metastatic dissemination...
four classes of selectin blocking agents: (i) carbohydrate based inhibitors targeting all P-, E-, and L-selectins, (ii) antihuman selectin antibodies, (iii)...
for the receptor L-selectin allowing for naive lymphocytes to exit the bloodstream into lymphoid tissues. GLYCAM1 binds to L-selectin by presenting one...
process by interacting with L-selectin, which is present on the surface of lymphocytes. The adhesion molecule L-selectin binds to sulfated carbohydrate...
function. Sulfatide also acts as an L-selectin and P-selectin ligand, but it does not act as an E- selectin ligand. Selectins are adhesion molecules that facilitate...
Adakveo among others, is a monoclonal antibody medication that binds to P-selectin. It is a medication used to reduce the frequency of vaso-occlusive crisis...
Davenpeck KL, et al. (October 1995). "Desmopressin induces endothelial P-selectin expression and leukocyte rolling in postcapillary venules". Blood. 86 (7):...
patients who are acutely or critically ill. Inhibition of factor XI, P-selectin, E-selectin, and a reduction in formation of neutrophil extracellular traps are...
Inflammatory cytokines induce the immediate expression of P-selectin on endothelial cell surfaces and P-selectin binds weakly to carbohydrate ligands on the surface...
and selectins. Cadherins and IgSF are homophilic CAMs, as they directly bind to the same type of CAMs on another cell, while integrins and selectins are...
(position themselves adjacent to the blood vessel endothelium) and undergo selectin-dependent capture followed by integrin-dependent adhesion in most cases...
(TCM cells) express CD45RO, C-C chemokine receptor type 7 (CCR7), and L-selectin (CD62L). Central memory T cells also have intermediate to high expression...
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