SIX4 information

SIX4
Identifiers
Aliases	SIX4, AREC3, SIX homeobox 4
External IDs	OMIM: 606342; MGI: 106034; HomoloGene: 69089; GeneCards: SIX4; OMA:SIX4 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	60,724,351 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	73,160,230 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; vastus lateralis muscle; ; deltoid muscle; ; parotid gland; ; tibialis anterior muscle; ; palpebral conjunctiva; ; tibia; ; Brodmann area 23; ; gastrocnemius muscle; ; middle temporal gyrus;
	Top expressed in
	intercostal muscle; ; maxillary prominence; ; parotid gland; ; utricle; ; foot; ; soleus muscle; ; digastric muscle; ; sternocleidomastoid muscle; ; quadriceps femoris muscle; ; triceps brachii muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	sequence-specific DNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; transcription cis-regulatory region binding;
Cellular component	cytoplasm; nucleus; transcription regulator complex;
Biological process	tongue development; trigeminal ganglion development; sarcomere organization; generation of neurons; regulation of branch elongation involved in ureteric bud branching; negative regulation of apoptotic process; positive regulation of branching involved in ureteric bud morphogenesis; transcription, DNA-templated; multicellular organism development; negative regulation of satellite cell differentiation; pharyngeal system development; anatomical structure morphogenesis; embryonic skeletal system morphogenesis; inner ear morphogenesis; myotome development; fungiform papilla morphogenesis; skeletal muscle fiber differentiation; positive regulation of ureteric bud formation; regulation of gene expression; embryonic cranial skeleton morphogenesis; anatomical structure development; regulation of synaptic assembly at neuromuscular junction; olfactory placode formation; myoblast migration; thymus development; positive regulation of transcription, DNA-templated; regulation of epithelial cell proliferation; metanephric mesenchyme development; male sex determination; skeletal muscle tissue development; negative regulation of neuron apoptotic process; regulation of protein localization; male sex differentiation; regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; male gonad development; negative regulation of transcription, DNA-templated; protein localization to nucleus;
	Sources:Amigo / QuickGO
Orthologs
	51804
	20474
	ENSG00000100625
	ENSMUSG00000034460
	Q9UIU6
	Q61321
	NM_017420
	NM_011382; NM_001362272
	NP_059116
	NP_035512; NP_001349201
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein SIX4 is a protein that in humans is encoded by the SIX4 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100625 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034460 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gallardo ME, Lopez-Rios J, Fernaud-Espinosa I, Granadino B, Sanz R, Ramos C, Ayuso C, Seller MJ, Brunner HG, Bovolenta P, Rodriguez de Cordoba S (Nov 1999). "Genomic cloning and characterization of the human homeobox gene SIX6 reveals a cluster of SIX genes in chromosome 14 and associates SIX6 hemizygosity with bilateral anophthalmia and pituitary anomalies". Genomics. 61 (1): 82–91. doi:10.1006/geno.1999.5916. PMID 10512683.
^ Ozaki H, Yamada K, Kobayashi M, Asakawa S, Minoshima S, Shimizu N, Kajitani M, Kawakami K (May 2000). "Structure and chromosome mapping of the human SIX4 and murine Six4 genes". Cytogenet Cell Genet. 87 (1–2): 108–12. doi:10.1159/000015407. PMID 10640827. S2CID 28013542.
^ "Entrez Gene: SIX4 sine oculis homeobox homolog 4 (Drosophila)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100625 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034460 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10512683-5] Gallardo ME, Lopez-Rios J, Fernaud-Espinosa I, Granadino B, Sanz R, Ramos C, Ayuso C, Seller MJ, Brunner HG, Bovolenta P, Rodriguez de Cordoba S (Nov 1999). "Genomic cloning and characterization of the human homeobox gene SIX6 reveals a cluster of SIX genes in chromosome 14 and associates SIX6 hemizygosity with bilateral anophthalmia and pituitary anomalies". Genomics. 61 (1): 82–91. doi:10.1006/geno.1999.5916. PMID 10512683.

[pmid10640827-6] Ozaki H, Yamada K, Kobayashi M, Asakawa S, Minoshima S, Shimizu N, Kajitani M, Kawakami K (May 2000). "Structure and chromosome mapping of the human SIX4 and murine Six4 genes". Cytogenet Cell Genet. 87 (1–2): 108–12. doi:10.1159/000015407. PMID 10640827. S2CID 28013542.

[entrez-7] "Entrez Gene: SIX4 sine oculis homeobox homolog 4 (Drosophila)".

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