oxidoreductase activity, acting on the CH-CH group of donors
succinate dehydrogenase activity
protein binding
succinate dehydrogenase (ubiquinone) activity
flavin adenine dinucleotide binding
electron transfer activity
Cellular component
mitochondrial inner membrane
myelin sheath
mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)
membrane
mitochondrion
nucleolus
plasma membrane succinate dehydrogenase complex
Biological process
succinate metabolic process
tricarboxylic acid cycle
nervous system development
electron transport chain
respiratory electron transport chain
mitochondrial electron transport, succinate to ubiquinone
anaerobic respiration
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
6389
66945
Ensembl
ENSG00000073578
ENSMUSG00000021577
UniProt
P31040
Q8K2B3
RefSeq (mRNA)
NM_001294332 NM_004168 NM_001330758
NM_023281
RefSeq (protein)
NP_001281261 NP_001317687 NP_004159
NP_075770
Location (UCSC)
Chr 5: 0.22 – 0.26 Mb
Chr 13: 74.47 – 74.5 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Succinate dehydrogenase complex, subunit A, flavoprotein variant is a protein that in humans is encoded by the SDHA gene.[5] This gene encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. SDHA contains the FAD binding site where succinate is deprotonated and converted to fumarate. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000073578 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000021577 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Hirawake H, Wang H, Kuramochi T, Kojima S, Kita K (July 1994). "Human complex II (succinate-ubiquinone oxidoreductase): cDNA cloning of the flavoprotein (Fp) subunit of liver mitochondria". Journal of Biochemistry. 116 (1): 221–7. doi:10.1093/oxfordjournals.jbchem.a124497. PMID 7798181.
subunit A, flavoprotein variant is a protein that in humans is encoded by the SDHA gene. This gene encodes a major catalytic subunit of succinate-ubiquinone...
flavoprotein (SdhA) and an iron-sulfur protein (SdhB), form a hydrophilic head where enzymatic activity of the complex takes place. SdhA contains a covalently...
and cannot replicate within cells, while deletion of the Dot/Icm effector SdhA results in destabilization of the vacuolar membrane and no bacterial replication...
27 July 1915 193096 Rudolf Neugebauer Born 21.12.1912. Usf 12.3.38 with SDHA 1938; 1941, promotion to KK of KK z.Pr. Neugebauer, Stapo Darmstadt. BBL...
succinate dehydrogenase, the other three being SDHA, SDHC and SDHD. The SDHB subunit is connected to the SDHA subunit on the hydrophilic, catalytic end of...
genes for the succinate dehydrogenase, SDHD (previously known as PGL1), SDHA, SDHC (previously PGL3) and SDHB have been identified as causing familial...
syndrome are located on chromosome 2 (BCS1L and NDUFA10); chromosome 5 (SDHA, NDUFS4, NDUFAF2, and NDUFA2); chromosome 8 (NDUFAF6), chromosome 10 (COX15);...
sdhA and sdhC. NrrF acts as an antisense RNA and is complementary to the junction between the second and third genes of the sdh operon (sdhD and sdhA)...
Complex II consists of four protein subunits: succinate dehydrogenase (SDHA); succinate dehydrogenase [ubiquinone] iron–sulfur subunit mitochondrial...
flavination of SDH1 (SDHA), another subunit of the SDH complex. It does so by incorporating the flavin adenine dinucleotide (FAD) cofactor into SDHA. Such flavination...
genomics approach was able to detect and verify the additional targets ptsI, sdhA and yobF. RydB RNA RyhB RNA RyeB RNA Wassarman, KM; Repoila F; Rosenow C;...
(Succinate CoQ reductase deficiency; succinate dehydrogenase deficiency) SDHA, SDHAF1, SDHD, SDHB AR PS252011 cytochrome b of complex III (MTCYB); Exercise...
the SDHB electron transport subunit which, in turn, is connected to the SDHA subunit. SDHD forms part of the transmembrane protein dimer with SDHC that...
the SDHB electron transport subunit which, in turn, is connected to the SDHA subunit. The SDHC protein is one of four nuclear-encoded subunits that comprise...
that make up the succinate dehydrogenase heterotetrmer, i.e., the SDHD, SDHA, SDHC, and SDHB genes (inactivation of any one of these genes causes paraganglioma...
1086615). In 1938, he joined the SS (SS number: 266047) and worked for the SDHA (Sicherheitsdiensthauptamt), the headquarters of the intelligence agency...
dependent expression of the IscR regulon. Further targets of FnrS are nagZ and sdhA. There is also evidence to suggest that the expression of FnrS is regulated...
"Siqat ud-Da'wat il-Haadiyat il-'Alaviyah" (ثقۃ الدعوۃ الهادیۃ العلویۃ, SDHA) meaning the most trusted, and Ra's ul-Hudood was awarded a special laqab...
Global Information
