mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)
mitochondrial inner membrane
mitochondrion
mitochondrial membranes
respiratory chain complex II
Biological process
succinate metabolic process
aerobic respiration
tricarboxylic acid cycle
respiratory electron transport chain
electron transport chain
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
6390
67680
Ensembl
ENSG00000117118
ENSMUSG00000009863
UniProt
P21912
Q9CQA3
RefSeq (mRNA)
NM_003000
NM_023374 NM_001355515
RefSeq (protein)
NP_002991
NP_075863 NP_001342444
Location (UCSC)
Chr 1: 17.02 – 17.05 Mb
Chr 4: 140.69 – 140.71 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (SDHB) also known as iron-sulfur subunit of complex II (Ip) is a protein that in humans is encoded by the SDHB gene.[5][6][7]
The succinate dehydrogenase (also called SDH or Complex II) protein complex catalyzes the oxidation of succinate (succinate + ubiquinone => fumarate + ubiquinol). SDHB is one of four protein subunits forming succinate dehydrogenase, the other three being SDHA, SDHC and SDHD. The SDHB subunit is connected to the SDHA subunit on the hydrophilic, catalytic end of the SDH complex. It is also connected to the SDHC/SDHD subunits on the hydrophobic end of the complex anchored in the mitochondrial membrane. The subunit is an iron-sulfur protein with three iron-sulfur clusters. It weighs 30 kDa.
^ abcGRCh38: Ensembl release 89: ENSG00000117118 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000009863 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: succinate dehydrogenase complex".
^Kita K, Oya H, Gennis RB, Ackrell BA, Kasahara M (January 1990). "Human complex II (succinate-ubiquinone oxidoreductase): cDNA cloning of iron sulfur (Ip) subunit of liver mitochondria". Biochem. Biophys. Res. Commun. 166 (1): 101–8. doi:10.1016/0006-291X(90)91916-G. PMID 2302193.
^Au HC, Ream-Robinson D, Bellew LA, Broomfield PL, Saghbini M, Scheffler IE (July 1995). "Structural organization of the gene encoding the human iron-sulfur subunit of succinate dehydrogenase". Gene. 159 (2): 249–53. doi:10.1016/0378-1119(95)00162-Y. PMID 7622059.
subunit, mitochondrial (SDHB) also known as iron-sulfur subunit of complex II (Ip) is a protein that in humans is encoded by the SDHB gene. The succinate...
The first two subunits, a flavoprotein (SdhA) and an iron-sulfur protein (SdhB), form a hydrophilic head where enzymatic activity of the complex takes place...
event ΔL497 (also known as MDR1h and found only in Botrytis group S); and sdhB alleles H272R, H272Y, N230I, and P225F (the only one conferring resistance...
other transmembrane subunit is SDHC. The SDHC/SDHD dimer is connected to the SDHB electron transport subunit which, in turn, is connected to the SDHA subunit...
SDHC (previously PGL3) and SDHB have been identified as causing familial head and neck paragangliomas. Mutations of SDHB play an important role in familial...
metastatic disease, particularly related to succinate dehydrogenase subunit B (SDHB) mutations, 18F-FDOPA fell inferior to the traditional FDG-PET. However,...
other transmembrane subunit is SDHD. The SDHC/SDHD dimer is connected to the SDHB electron transport subunit which, in turn, is connected to the SDHA subunit...
and promotes the maturation of the SDHB subunit of the SDH catalytic dimer. The iron-sulfur (Fe-S) protein subunit SDHB is required for functional succinate...
patients for SDH mutation testing in early stages of cancer. The absence of SDHB in IHC staining would be linked to the presence of SDH oncogene mutations...
Redevelopment. In 2019 the SDHB released the official design plans for the redevelopment of Dunedin Hospital. On 17 May 2019, the SDHB announced that WSP Opus...
Society Te Apārangi. Retrieved 17 June 2023. Houlahan, Mike (9 June 2022). "SDHB meets for last time before restructure". Otago Daily Times. Retrieved 24...
reductase deficiency; succinate dehydrogenase deficiency) SDHA, SDHAF1, SDHD, SDHB AR PS252011 cytochrome b of complex III (MTCYB); Exercise intolerance; multisystem...
(succinate:ubiquinone oxidoreductase) subunit genes (SDHD, SDHAF2, SDHC, SDHB). PGL-1 is associated with SDHD mutation, and most PGL-1 individuals with...
pathway involving the succinate dehydrogenase (SDH) subunits SDHD, SDHC and SDHB. Approximately 85% GISTs are associated with an abnormal c-KIT pathway. c-KIT...
to the protein via four Cys residues. 2Fe–2S: AOX1; FDX1; FDX2; NDUFS1; SDHB; XDH; 4Fe–4S: ABCE1; DPYD; NDUFS8; Mortenson LE, Valentine RC, Carnahan JE...
shock entrant in SDHB race". Otago Daily Times. Retrieved 27 August 2019. Houlahan, Mike (13 October 2019). "Cull and Chambers top SDHB poll". Otago Daily...
widespread resistance to SDHIs here. They find several etiologies, with various sdhB alleles producing the resistance. H272R resistance to boscalid, H272R or...
Health Board (SDHB) also established an emergency operations centre to ensure that staff were able to travel safely to and from work. The SDHB also assisted...
Anastasios N.; Karaoglanidis, George S. (2013). "Differential Effect of SdhB Gene Mutations on the Sensitivity to SDHI Fungicides in Botrytis cinerea"...
2020. Retrieved 3 May 2020. "Grant hopes new structure will 'future-proof' SDHB". Stuff. 3 December 2019. Retrieved 14 November 2020. "Statistical area 1...
ubiquinol). Electrons removed from succinate transfer to SDHA, transfer across SDHB through iron sulphur clusters to the SDHC/SDHD subunits on the hydrophobic...
on SDHA or SDHAF1, but other pathogenic mutations for CII are known for SDHB and SDHD. SDHA is the only SDHx gene reported to date in which dominant pathogenic...
Global Information
