Not to be confused with Cuillin, a mountain range in Scotland, or with Culin.
Cullin
structure of the cul1-rbx1-skp1-f boxskp2 scf ubiquitin ligase complex
Identifiers
Symbol
Cullin
Pfam
PF00888
InterPro
IPR001373
PROSITE
PDOC00967
SCOP2
1ldj / SCOPe / SUPFAM
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
Cullin protein neddylation domain
structure of the cul1-rbx1-skp1-f boxskp2 scf ubiquitin ligase complex
Identifiers
Symbol
Cullin_Nedd8
Pfam
PF10557
InterPro
IPR019559
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
Cullins are a family of hydrophobic scaffold proteins which provide support for ubiquitin ligases (E3). All eukaryotes appear to have cullins. They combine with RING proteins to form Cullin-RING ubiquitin ligases (CRLs) that are highly diverse and play a role in myriad cellular processes, most notably protein degradation by ubiquitination.[1][2]
The human genome contains eight cullin genes
CUL1, part of SCF complex
CUL2, part of ECS complex (Elongin C - CUL2 - SOCS-box)
CUL3, part of CUL3-BTB complex
CUL4A
CUL4B
CUL5
CUL7
CUL9, also known as PARC
There is also a more distant member called ANAPC2 (or APC2), part of the Anaphase-promoting complex.
CUL1, 2, 3, 4A, 4B, 5 and 7 each form part of a multi-subunit ubiquitin complex.
^Bosu, Dimple R.; Kipreos, Edward T. (2008). "Cullin-RING ubiquitin ligases: Global regulation and activation cycles". Cell Division. 3: 7. doi:10.1186/1747-1028-3-7. PMC 2266742. PMID 18282298.
^Bruce, Alberts (2014-11-18). Molecular biology of the cell (Sixth ed.). New York, NY. ISBN 9780815344322. OCLC 887605755.{{cite book}}: CS1 maint: location missing publisher (link)
Cullins are a family of hydrophobic scaffold proteins which provide support for ubiquitin ligases (E3). All eukaryotes appear to have cullins. They combine...
Cullins is a surname. Notable people with the surname include: Paris Cullins, American comics artist Peter K. Cullins (1928–2012), American admiral Ryan...
Lough Cullin (Irish: Loch Cuilinn, meaning 'holly lake') is a lake in County Mayo in Ireland. With its immediate neighbour to the north, Lough Conn, it...
McCullin is a surname and may refer to: Don McCullin, a British photojournalist McCullin (film), a 2012 British documentary film about Don McCullin This...
Mitch Cullin (born March 23, 1968) is an American writer. He is the author of seven novels, and one short story collection. He currently resides in Arcadia...
Arthur Cullin (1862–1926) was a British actor of the silent era who was born in Kensington, London. He is often credited as Arthur M. Cullin. The Answer...
Ryan P. Cullins is a Canadian Progressive Conservative politician who has represented Fredericton-York in the Legislative Assembly of New Brunswick since...
Sir Donald McCullin CBE (born 9 October 1935) is a British photojournalist, particularly recognised for his war photography and images of urban strife...
Cullin-2 is a protein that in humans is encoded by the CUL2 gene. CUL2 has been shown to interact with: CAND1, DCUN1D1, RBX1, SAP130, TCEB2 and Von Hippel-Lindau...
Michel Cullin (17 September 1944 – 3 March 2020) was "Maître de conférences" at the University of Nice and director of French-Austrian relations at the...
agreed to leave Victoria to help found and manage a new family station, Cullin-la-ringo, on the Nogoa River in outback Queensland. He prepared for six...
seventh largest lake. With its immediate neighbour to the south, Lough Cullin, it is connected to the Atlantic Ocean by the River Moy. Lough Conn is noted...
CDK2 associated cullin domain 1 is a protein that in humans is encoded by the CACUL1 gene. GRCh38: Ensembl release 89: ENSG00000151893 – Ensembl, May 2017...
Tideland is the third published book by author Mitch Cullin, and is the third installment of the writer's Texas Trilogy that also includes the coming-of-age...
in the British television series Doctors as Holden, Casualty as Johnny Cullin, and Afterlife as Darren. He also had a minor role in the film Children...
Paris Cullins is an American comics artist best known for his work on DC Comics' Blue Devil and Blue Beetle, and Hyperkind from the Marvel Comics imprint...
Aboriginal lives. First Nations warriors killed 19 settlers during the Cullin-La-Ringo massacre on 17 October 1861. In the weeks afterwards, police, native...
Archived from the original on April 10, 2022. Retrieved April 21, 2022. Cullins, Ashley (August 31, 2020). "Johnny Depp Seeks Defamation Trial Delay Because...
for his starring role in Sex Drive (2008), as well as for playing Mark Cullin in the science fiction TV series Kyle XY, Eddie Orlofsky in Desperate Housewives...
CNN. Archived from the original on May 21, 2019. Retrieved May 21, 2019. Cullins, Ashley (April 23, 2019). "'Stranger Things' Trial Split Into Two Phases"...
Global Information