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retinol isomerase
Identifiers
EC no.
5.2.1.7
CAS no.
109740-80-9
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IntEnz view
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BRENDA entry
ExPASy
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KEGG
KEGG entry
MetaCyc
metabolic pathway
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profile
PDB structures
RCSB PDB PDBe PDBsum
Gene Ontology
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articles
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NCBI
proteins
In enzymology, a retinol isomerase (EC 5.2.1.7) is an enzyme that catalyzes the chemical reaction
all-trans-retinol 11-cis-retinol
Hence, this enzyme has one substrate, all-trans-retinol, and one product, 11-cis-retinol. These enzymes are alternatively referred to as retinoid isomerases.
This enzyme belongs to the family of isomerases, specifically cis-trans isomerases. The systematic name of this enzyme class is all-trans-retinol 11-cis-trans-isomerase. This enzyme is also called all-trans-retinol isomerase. This enzyme participates in retinol metabolism.
In vertebrates, RPE65 is the active retinol isomerase in the visual cycle. A lack of RPE65 function results in congenital blindness in children (specifically Leber congenital amaurosis). Emixustat, a partial inhibitor of RPE65, is currently in FDA clinical trials for the treatment of age-related macular degeneration.
In enzymology, a retinolisomerase (EC 5.2.1.7) is an enzyme that catalyzes the chemical reaction all-trans-retinol ⇌ {\displaystyle \rightleftharpoons...
visual pigment component). RPE65 is also referred to as retinolisomerase or retinoid isomerase, owing to past debates about the enzyme's substrate and...
cells. There, it is transformed into 11-cis retinol by all-trans retinolisomerase, and can either be stored as retinyl esters within Müller cells, or...
isomerase, and retinoid isomerase. This enzyme participates in the retinol metabolism. HUBBARD R (1956). "Retinene isomerase". J. Gen. Physiol. 39 (6):...
emixustat's planned mechanism of action. Visual phototransduction Retinolisomerase Bavik C, Henry SH, Zhang Y, Mitts K, McGinn T, Budzynski E, et al...
γ-carotene) have vitamin A activity (meaning that they can be converted to retinol). In the eye, lutein, meso-zeaxanthin, and zeaxanthin are present as macular...
acyltransferase (LRAT) and then converted to 11-cis-retinol by the isomerohydrolase RPE65. The isomerase activity of RPE65 has been shown; it is uncertain...
enzymes involved in the cleavage of carotenoids to produce, for example, retinol, commonly known as vitamin A. This family includes an enzyme known as RPE65...
Diterpenes also form the basis for biologically important compounds such as retinol, retinal, and phytol. Sesterterpenes, terpenes having 25 carbons and five...
exists in virtually all life forms. The enzyme isopentenyl pyrophosphate isomerase catalyzes isomerization between DMAPP and IPP. In the mevalonate pathway...
pathways, IPP is isomerized to DMAPP by the enzyme isopentenyl pyrophosphate isomerase. Geranyl pyrophosphate is the precursor to monoterpenes (and hence monoterpenoids)...
to dimethylallyl pyrophosphate by the enzyme isopentenyl pyrophosphate isomerase. IPP can be synthesised via an alternative non-mevalonate pathway of isoprenoid...
1 and 2 using NADPH to form (+)-cis-isopulegone. (+)-cis-Isopulegone isomerase (iPI) then isomerizes the remaining double bond to form (+)-pulegone....
worked under George Wald, investigating the biochemistry of retinal and retinol. According to an interview given by Ruth, together they built on the work...
oscillating functions: the oxidation of NADH to NAD+ and a protein disulfide isomerase-like activity, unprecedented in the biochemical literature. Regarding...
reticulum (ER), as it has been shown to co-localize with protein disulfide-isomerase, a protein known to be a marker for the ER. PLD3 may also be localized...
normal, healthy retina, this protein acts as an isomerase, converting all-trans-retinol to 11-cis-retinol in the visual cycle. Loss of this protein results...
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