ENOX2 information

ENOX2
Identifiers
Aliases	ENOX2, APK1, COVA1, tNOX, ecto-NOX disulfide-thiol exchanger 2
External IDs	OMIM: 300282; MGI: 2384799; HomoloGene: 17120; GeneCards: ENOX2; OMA:ENOX2 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	130,903,234 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	48,377,136 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; gonad; ; tendon of biceps brachii; ; popliteal artery; ; tibial arteries; ; right coronary artery; ; left coronary artery; ; testicle; ; thoracic aorta; ; monocyte;
	Top expressed in
	habenula; ; interventricular septum; ; Paneth cell; ; otic vesicle; ; muscle of thigh; ; trigeminal ganglion; ; sciatic nerve; ; saccule; ; substantia nigra; ; ventricular zone;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein-disulfide reductase activity; oxidoreductase activity; protein binding; nucleic acid binding; RNA binding;
Cellular component	extracellular region; cytosol; plasma membrane; membrane; external side of plasma membrane; extracellular space;
Biological process	cell growth; regulation of growth; ultradian rhythm; rhythmic process;
	Sources:Amigo / QuickGO
Orthologs
	10495
	209224
	ENSG00000165675
	ENSMUSG00000031109
	Q16206
	Q8R0Z2
NM_001281736; NM_006375; NM_182314; NM_001382516; NM_001382517;
	NM_001382518; NM_001382519; NM_001382520; NM_001382521; NM_001382522
NM_001271447; NM_001271448; NM_001271449; NM_001271450; NM_001271451;
	NM_145951
NP_001268665; NP_006366; NP_872114; NP_001369445; NP_001369446;
	NP_001369447; NP_001369448; NP_001369449; NP_001369450; NP_001369451
NP_001258376; NP_001258377; NP_001258378; NP_001258379; NP_001258380;
	NP_666063
	Wikidata
View/Edit Human	View/Edit Mouse

ENOX2 is a gene located on the long arm of the X chromosome in humans.^[5] The gene encodes the protein Ecto-NOX disulfide-thiol exchanger 2, a member of the NOX family of NADPH oxidases.^[6]^[7]^[8]

Ecto-NOX disulfide-thiol exchanger 2 is a growth-related cell surface protein. It was identified because it reacts with the monoclonal antibody K1 in cells, such as the ovarian carcinoma line OVCAR-3, also expressing the CAKI surface glycoprotein.^[6] The encoded protein has two enzymatic activities: catalysis of hydroquinone or NADH oxidation, and protein disulfide interchange. The two activities alternate with a period length of about 24 minutes. The encoded protein also displays prion-like properties. Two transcript variants encoding different isoforms have been found for this gene.^[9]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000165675 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031109 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "ENOX2 ecto-NOX disulfide-thiol exchanger 2 [ Homo sapiens (human) ]". NCBI. Retrieved 2016-10-16.
^ ^a ^b Chang K, Pastan I (May 1994). "Molecular cloning and expression of a cDNA encoding a protein detected by the K1 antibody from an ovarian carcinoma (OVCAR-3) cell line". Int J Cancer. 57 (1): 90–7. doi:10.1002/ijc.2910570117. PMID 8150545. S2CID 1970834.
^ Chueh PJ, Kim C, Cho N, Morre DM, Morre DJ (Mar 2002). "Molecular cloning and characterization of a tumor-associated, growth-related, and time-keeping hydroquinone (NADH) oxidase (tNOX) of the HeLa cell surface". Biochemistry. 41 (11): 3732–41. doi:10.1021/bi012041t. PMID 11888291.
^ Morré, D. James; Morré, Dorothy M. (2003-08-01). "Cell surface NADH oxidases (ECTO-NOX proteins) with roles in cancer, cellular time-keeping, growth, aging and neurodegenerative diseases". Free Radical Research. 37 (8): 795–808. doi:10.1080/1071576031000083107. ISSN 1071-5762. PMID 14567438. S2CID 28452870.
^ "Entrez Gene: COVA1 cytosolic ovarian carcinoma antigen 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000165675 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031109 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[:0-5] "ENOX2 ecto-NOX disulfide-thiol exchanger 2 [ Homo sapiens (human) ]". NCBI. Retrieved 2016-10-16.

[pmid8150545-6] Chang K, Pastan I (May 1994). "Molecular cloning and expression of a cDNA encoding a protein detected by the K1 antibody from an ovarian carcinoma (OVCAR-3) cell line". Int J Cancer. 57 (1): 90–7. doi:10.1002/ijc.2910570117. PMID 8150545. S2CID 1970834.

[pmid11888291-7] Chueh PJ, Kim C, Cho N, Morre DM, Morre DJ (Mar 2002). "Molecular cloning and characterization of a tumor-associated, growth-related, and time-keeping hydroquinone (NADH) oxidase (tNOX) of the HeLa cell surface". Biochemistry. 41 (11): 3732–41. doi:10.1021/bi012041t. PMID 11888291.

[:1-8] Morré, D. James; Morré, Dorothy M. (2003-08-01). "Cell surface NADH oxidases (ECTO-NOX proteins) with roles in cancer, cellular time-keeping, growth, aging and neurodegenerative diseases". Free Radical Research. 37 (8): 795–808. doi:10.1080/1071576031000083107. ISSN 1071-5762. PMID 14567438. S2CID 28452870.

[entrez2-9] "Entrez Gene: COVA1 cytosolic ovarian carcinoma antigen 1".

ENOX2 information

and 2 Related for: ENOX2 information

ENOX2

RNA recognition motif