Chemical compound
Regorafenib Trade names Stivarga, Regonix Other names BAY 73-4506 AHFS/Drugs.com Monograph MedlinePlus a613004 License data
EU EMA: by INN
US DailyMed: Regorafenib
Pregnancy category Routes of administration By mouth ATC code Legal status
AU : S4 (Prescription only)
CA : ℞-only
UK : POM (Prescription only)
US : WARNING [1] Rx-only
Bioavailability 69-83% Protein binding 99.5% Metabolism Hepatic (UGT1A9-mediated) Elimination half-life 20-30 hours Excretion Feces (71%), urine (19%)
4-[4-({[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N -methylpyridine-2-carboxamide hydrate
CAS Number PubChem CID DrugBank ChemSpider UNII KEGG ChEBI CHEBI:68647 Y ChEMBL CompTox Dashboard (EPA ) DTXSID60226441 ECHA InfoCard 100.248.939 Formula C 21 H 15 Cl F 4 N 4 O 3 Molar mass 482.82 g·mol−1 3D model (JSmol)
CNC(=O)c1cc(ccn1)Oc2ccc(c(c2)F)NC(=O)Nc3ccc(c(c3)C(F)(F)F)Cl
InChI=1S/C21H15ClF4N4O3/c1-27-19(31)18-10-13(6-7-28-18)33-12-3-5-17(16(23)9-12)30-20(32)29-11-2-4-15(22)14(8-11)21(24,25)26/h2-10H,1H3,(H,27,31)(H2,29,30,32)
Key:FNHKPVJBJVTLMP-UHFFFAOYSA-N
Regorafenib , sold under the brand name Stivarga among others, is an oral multi-kinase inhibitor developed by Bayer which targets angiogenic, stromal and oncogenic receptor tyrosine kinase (RTK). Regorafenib shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Since 2009 it was studied as a potential treatment option in multiple tumor types.[2] By 2015 it had two US approvals for advanced cancers.
^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov . FDA. Retrieved 22 Oct 2023 .
^ "Bayer Announces New Data on Oncology Portfolio To Be Presented at the ECCO-ESMO Congress 2009". Retrieved 2009-09-19 .
Last Update: 2023-12-20T21:36:33Z
Regorafenib , sold under the brand name Stivarga among others, is an oral multi-kinase inhibitor developed by Bayer which targets angiogenic, stromal and...
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Last Update: 2024-01-04T21:44:12Z
months compared to 5.6 months for regorafenib . The difference in median PFS between the avapritinib and regorafenib groups was not statistically significant...
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Last Update: 2024-04-27T02:56:13Z
therapy if RAS wild type, and at least one of trifluridine/tipiracil or regorafenib . FRESCO, a multicenter, placebo-controlled trial conducted in China,...
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Last Update: 2023-12-18T15:34:25Z
2013. "FDA Approves Regorafenib (Stivarga) for GIST". CancerNetwork. February 26, 2013. Retrieved July 29, 2013. "Regorafenib Prescribing Information"...
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Last Update: 2024-03-08T10:23:49Z
dasatinib, neratinib, eltrombopag, ibrutinib, lenvatinib, palbociclib, regorafenib , tofacitinib, and trelagliptin. BEACON Medicare Limited(BML) is the exclusive...
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Last Update: 2024-05-15T00:45:19Z
Lapatinib Lenvatinib Motesanib Nintedanib Pazopanib Pegaptanib Rebastinib Regorafenib Semaxanib Sorafenib Sunitinib Toceranib Tivozanib Vandetanib WHI-P 154...
Word Count : 13791
Last Update: 2024-05-15T02:35:00Z
Lapatinib Lenvatinib Motesanib Nintedanib Pazopanib Pegaptanib Rebastinib Regorafenib Semaxanib Sorafenib Sunitinib Toceranib Tivozanib Vandetanib WHI-P 154...
Word Count : 15817
Last Update: 2024-01-23T23:55:17Z
randomized study of zanzalintinib in combination with atezolizumab versus regorafenib in metastatic colorectal cancer. STELLAR-304 (NCT05678673) is a phase...
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Last Update: 2024-03-21T22:16:34Z
Lapatinib Lenvatinib Motesanib Nintedanib Pazopanib Pegaptanib Rebastinib Regorafenib Semaxanib Sorafenib Sunitinib Toceranib Tivozanib Vandetanib WHI-P 154...
Word Count : 3413
Last Update: 2024-05-10T19:32:32Z
products were Xarelto (rivaroxaban), Eylea (aflibercept), Stivarga (regorafenib ), Xofigo (radium-223), and Adempas (riociguat).: 93 Top-selling products...
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Last Update: 2024-01-12T10:54:50Z
Lapatinib Lenvatinib Motesanib Nintedanib Pazopanib Pegaptanib Rebastinib Regorafenib Semaxanib Sorafenib Sunitinib Toceranib Tivozanib Vandetanib WHI-P 154...
Word Count : 1049
Last Update: 2024-04-12T21:07:16Z
Lapatinib Lenvatinib Motesanib Nintedanib Pazopanib Pegaptanib Rebastinib Regorafenib Semaxanib Sorafenib Sunitinib Toceranib Tivozanib Vandetanib WHI-P 154...
Word Count : 2053
Last Update: 2024-03-14T23:46:28Z
Midostaurin Nintedanib Pazopanib Pemigatinib Pexidartinib Quizartinib Regorafenib Ripretinib Sorafenib Sunitinib Tebentafusp Tepotinib Vandetanib Venetoclax...
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Last Update: 2024-04-22T02:25:33Z
Lapatinib Lenvatinib Motesanib Nintedanib Pazopanib Pegaptanib Rebastinib Regorafenib Semaxanib Sorafenib Sunitinib Toceranib Tivozanib Vandetanib WHI-P 154...
Word Count : 5993
Last Update: 2024-05-06T06:24:28Z
have been identified for clinical benefit in GIST: imatinib, sunitinib, regorafenib , ripretinib and avapritinib. Imatinib (Glivec/Gleevec), an orally administered...
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Last Update: 2024-02-28T03:22:37Z
Lapatinib Lenvatinib Motesanib Nintedanib Pazopanib Pegaptanib Rebastinib Regorafenib Semaxanib Sorafenib Sunitinib Toceranib Tivozanib Vandetanib WHI-P 154...
Word Count : 1735
Last Update: 2024-03-10T06:38:02Z
Lapatinib Lenvatinib Motesanib Nintedanib Pazopanib Pegaptanib Rebastinib Regorafenib Semaxanib Sorafenib Sunitinib Toceranib Tivozanib Vandetanib WHI-P 154...
Word Count : 1543
Last Update: 2024-04-10T06:21:42Z
Lapatinib Lenvatinib Motesanib Nintedanib Pazopanib Pegaptanib Rebastinib Regorafenib Semaxanib Sorafenib Sunitinib Toceranib Tivozanib Vandetanib WHI-P 154...
Word Count : 3010
Last Update: 2024-04-24T03:21:31Z
Lapatinib Lenvatinib Motesanib Nintedanib Pazopanib Pegaptanib Rebastinib Regorafenib Semaxanib Sorafenib Sunitinib Toceranib Tivozanib Vandetanib WHI-P 154...
Word Count : 1122
Last Update: 2024-05-14T06:10:24Z
Lapatinib Lenvatinib Motesanib Nintedanib Pazopanib Pegaptanib Rebastinib Regorafenib Semaxanib Sorafenib Sunitinib Toceranib Tivozanib Vandetanib WHI-P 154...
Word Count : 8668
Last Update: 2024-01-03T04:41:31Z
Lapatinib Lenvatinib Motesanib Nintedanib Pazopanib Pegaptanib Rebastinib Regorafenib Semaxanib Sorafenib Sunitinib Toceranib Tivozanib Vandetanib WHI-P 154...
Word Count : 1994
Last Update: 2024-04-02T04:09:52Z
Barghout VE, Huynh L, et al. (December 2021). "Trifluridine/Tipiracil and Regorafenib in Patients with Metastatic Colorectal Cancer: A Retrospective Study...
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Last Update: 2024-04-27T21:55:20Z
Lapatinib Lenvatinib Motesanib Nintedanib Pazopanib Pegaptanib Rebastinib Regorafenib Semaxanib Sorafenib Sunitinib Toceranib Tivozanib Vandetanib WHI-P 154...
Word Count : 12661
Last Update: 2024-01-01T05:15:47Z
Lapatinib Lenvatinib Motesanib Nintedanib Pazopanib Pegaptanib Rebastinib Regorafenib Semaxanib Sorafenib Sunitinib Toceranib Tivozanib Vandetanib WHI-P 154...
Word Count : 596
Last Update: 2024-01-06T04:08:10Z
Lapatinib Lenvatinib Motesanib Nintedanib Pazopanib Pegaptanib Rebastinib Regorafenib Semaxanib Sorafenib Sunitinib Toceranib Tivozanib Vandetanib WHI-P 154...
Word Count : 1784
Last Update: 2024-05-06T18:39:04Z
Midostaurin Nintedanib Pazopanib Pemigatinib Pexidartinib Quizartinib Regorafenib Ripretinib Sorafenib Sunitinib Tebentafusp Tepotinib Vandetanib Venetoclax...
Word Count : 741
Last Update: 2024-04-26T23:53:23Z
Lapatinib Lenvatinib Motesanib Nintedanib Pazopanib Pegaptanib Rebastinib Regorafenib Semaxanib Sorafenib Sunitinib Toceranib Tivozanib Vandetanib WHI-P 154...
Word Count : 2786