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RRM2 information


RRM2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRRM2, R2, RR2, RR2M, ribonucleotide reductase regulatory subunit M2
External IDsOMIM: 180390; MGI: 98181; HomoloGene: 20277; GeneCards: RRM2; OMA:RRM2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001165931
NM_001034

NM_009104

RefSeq (protein)

NP_001025
NP_001159403

NP_033130

Location (UCSC)Chr 2: 10.12 – 10.21 MbChr 12: 24.76 – 24.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ribonucleoside-diphosphate reductase subunit M2, also known as ribonucleotide reductase small subunit, is an enzyme that in humans is encoded by the RRM2 gene.[5][6]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000171848 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020649 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: ribonucleotide reductase M2".
  6. ^ Pavloff N, Rivard D, Masson S, Shen SH, Mes-Masson AM (1992). "Sequence analysis of the large and small subunits of human ribonucleotide reductase". DNA Seq. 2 (4): 227–34. doi:10.3109/10425179209020807. PMID 1627826.

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RRM2

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ribonucleotide reductase small subunit, is an enzyme that in humans is encoded by the RRM2 gene. This gene encodes one of two non-identical subunits for ribonucleotide...

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Functional genomics

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Deep mutational scan of the RNA recognition motif (RRM2) of a yeast PolyA binding protein (Pab1)...

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CCNF

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through RRM2 and CP110 control centrosome duplication and reduce the frequency of genomic mutations. So far, mutations in CCNF and increased RRM2 expression...

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Gemcitabine

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deaminase, and NT5C) and that express its other intracellular targets (RRM1, RRM2, and RRM2B) lead to variations in response to the drug. Research has also...

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RNA interference

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amyloidosis II Recruiting Alnylam Pharmaceuticals NCT01617967 CALAA-01 RRM2 Cyclodextrin NP Solid tumours I Active Calando Pharmaceuticals NCT00689065...

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List of enzymes

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4.4 Vitamin-K-epoxide reductase (warfarin-insensitive) EC 1.17.4.5 RRM1 RRM2 RRM2B Category:EC 1.17.5 Caffeine dehydrogenase EC 1.17.5.2 Category:EC 1...

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Ribonucleotide reductase

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RRM1 gene while there are two isoforms of the beta subunit, encoded by the RRM2 and RRM2B genes: Each Class I alpha monomer consists of three domains: one...

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RNA silencing

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Liver tumor PLK1 Cancer FANG Solid tumor Furin Cancer CALAA-01 Solid tumor RRM2 Cancer SPC2996 chronic lymphocytic leukemia BCL-2 Cancer ALN-VSP02 Solid...

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U2AF2

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binding affinity to the Py tract on its adjacent 3’ splice site. The RRM1 and RRM2 are sufficient for specific RNA/protein binding, while RRM3 is responsible...

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ExPRESS Logistics Carrier

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and disposed of on Cygnus NG-16. ) (RRM3 was installed in 2018 to replace RRM2. Payload malfunctioned in 2019 and its payload of methane and ammonia was...

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Stephen Elledge

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increases when DNA is damaged. The human counterparts of RNR2, or homologs, are RRM2 and RRM2B. Over the next decade, he continued the search for genes and proteins...

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GBP2

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conserved. GBP2 gene can interact with the RNA via the domain RRM1 and RRM2. The RRM2 domain can recognize the core motif GGUC present in the RNA. Besides...

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PABPC1

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PABPC1 contains four RNA-recognition motifs (RRMs). The first two, RRM1 and RRM2, bind both α-importin and the poly(A) tail of processed mRNA. This feature...

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PTBP1

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Polypyrimidine Tract Binding Protein Isoform 1 (PTB1) 1sjr: NMR Structure of RRM2 from Human Polypyrimidine Tract Binding Protein Isoform 1 (PTB1) 2ad9: Solution...

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Prp24

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domain while the cleft between RRMs 1 and 2 including the beta-sheet face of RRM2 is a sequence-specific RNA binding site. The C-terminal motif is required...

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RRM2B

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ribonucleotide reductase by protein-protein interaction with p53R2 as well as hRRM2 subunits". Cancer Research. 63 (5): 980–6. PMID 12615712. Zhou B, Liu X,...

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TMEM242

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GPR42, BCL2L13, HEATR1, IZUMO4, ARID1B, SIAE, EDARADD, URB1, ZDHHC14, KIF11, RRM2, KCTD13, TMEM31, NDUFA3, SGPL1, CNR2, and GJA8. All of the listed proteins...

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RBM4

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mutation affecting both RNA binding domains is lethal, and a mutation in RRM2 leads to female infertility or developmental arrest in offspring. These two...

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RBM10

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called RNA recognition motifs (RRMs). RBM10 contains two RRMs (RRM1 and RRM2) and other domains such as two zinc fingers (ZnFs), an octamer repeat (OCRE)...

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RRM1

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ribonucleotide reductase by protein-protein interaction with p53R2 as well as hRRM2 subunits". Cancer Res. 63 (5): 980–6. PMID 12615712. Gautam A, Li ZR, Bepler...

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