U2AF2 information

U2AF2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1JMT, 1O0P, 1OPI, 1U2F, 2G4B, 2HZC, 2M0G, 2U2F, 2YH0, 2YH1, 3VAF, 3VAG, 3VAH, 3VAI, 3VAJ, 3VAK, 3VAL, 3VAM, 4FXW, 4TU7, 4TU8, 4TU9, 5EV1, 5EV3, 5EV4, 5EV2
Identifiers
Aliases	U2AF2, U2AF65, U2 small nuclear RNA auxiliary factor 2
External IDs	OMIM: 191318; MGI: 98886; HomoloGene: 110853; GeneCards: U2AF2; OMA:U2AF2 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	55,674,716 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	5,079,938 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; canal of the cervix; ; granulocyte; ; anterior pituitary; ; right ovary; ; body of uterus; ; right lobe of thyroid gland; ; left ovary; ; left lobe of thyroid gland; ; right hemisphere of cerebellum;
	Top expressed in
	ventricular zone; ; neural layer of retina; ; yolk sac; ; lip; ; epiblast; ; granulocyte; ; dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; primary visual cortex; ; thymus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	pre-mRNA 3'-splice site binding; poly-pyrimidine tract binding; protein binding; nucleic acid binding; enzyme binding; C2H2 zinc finger domain binding; RNA binding;
Cellular component	nuclear speck; U2AF complex; Prp19 complex; spliceosomal complex; commitment complex; U2-type prespliceosome; nucleus; nucleoplasm;
Biological process	mRNA splicing, via spliceosome; termination of RNA polymerase II transcription; positive regulation of protein targeting to mitochondrion; mRNA processing; mRNA export from nucleus; negative regulation of mRNA splicing, via spliceosome; regulation of autophagy of mitochondrion; positive regulation of RNA splicing; mRNA 3'-end processing; RNA splicing; RNA export from nucleus; negative regulation of protein ubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	11338
	22185
	ENSG00000063244
	ENSMUSG00000030435
	P26368
	P26369
	NM_001012478; NM_007279
	NM_001205231; NM_133671
	NP_001012496; NP_009210
NP_001192160; NP_598432; NP_001390074; NP_001390075; NP_001390076;
	NP_001390077; NP_001390078; NP_001390079; NP_001390080; NP_001390083; NP_001390084; NP_001390085; NP_001390087; NP_001390088; NP_001390082
	Wikidata
View/Edit Human	View/Edit Mouse

Splicing factor U2AF 65 kDa subunit is a protein that in humans is encoded by the U2AF2 gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000063244 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030435 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zamore PD, Patton JG, Green MR (February 1992). "Cloning and domain structure of the mammalian splicing factor U2AF". Nature. 355 (6361): 609–614. Bibcode:1992Natur.355..609Z. doi:10.1038/355609a0. PMID 1538748. S2CID 4332390.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000063244 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030435 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1538748-5] Zamore PD, Patton JG, Green MR (February 1992). "Cloning and domain structure of the mammalian splicing factor U2AF". Nature. 355 (6361): 609–614. Bibcode:1992Natur.355..609Z. doi:10.1038/355609a0. PMID 1538748. S2CID 4332390.

U2AF2 information

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Nucleic acid secondary structure

RNA splicing

Zebrafish

RNA recognition motif

Microsatellite

Exonic splicing enhancer

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SFRS11

PUF60

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