Weight loss, abstinence from drinking alcohol, allopurinol[7]
Treatment
NSAIDs, glucocorticoids, colchicine[4][8]
Frequency
1–2% (developed world)[7]
Gout (/ɡaʊt/GOWT[9]) is a form of inflammatory arthritis characterized by recurrent attacks of a red, tender, hot, and swollen joint,[4][10] caused by the deposition of needle-like crystals of uric acid known as monosodium urate crystals.[11] Pain typically comes on rapidly, reaching maximal intensity in less than 12 hours.[7] The joint at the base of the big toe is affected (Podagra) in about half of cases.[12][13] It may also result in tophi, kidney stones, or kidney damage.[3]
Gout is due to persistently elevated levels of uric acid (urate) in the blood (hyperuricemia).[4][7] This occurs from a combination of diet, other health problems, and genetic factors.[3][4] At high levels, uric acid crystallizes and the crystals deposit in joints, tendons, and surrounding tissues, resulting in an attack of gout.[3] Gout occurs more commonly in those who regularly drink beer or sugar-sweetened beverages; eat foods that are high in purines such as liver, shellfish, or anchovies; or are overweight.[3][5] Diagnosis of gout may be confirmed by the presence of crystals in the joint fluid or in a deposit outside the joint.[3] Blood uric acid levels may be normal during an attack.[3]
Treatment with nonsteroidal anti-inflammatory drugs (NSAIDs), glucocorticoids, or colchicine improves symptoms.[3][4][14] Once the acute attack subsides, levels of uric acid can be lowered via lifestyle changes and in those with frequent attacks, allopurinol or probenecid provides long-term prevention.[7] Taking vitamin C and having a diet high in low-fat dairy products may be preventive.[15][16]
Gout affects about 1–2% of adults in the developed world at some point in their lives.[7] It has become more common in recent decades.[3] This is believed to be due to increasing risk factors in the population, such as metabolic syndrome, longer life expectancy, and changes in diet.[7] Older males are most commonly affected.[3] Gout was historically known as "the disease of kings" or "rich man's disease".[7][17] It has been recognized at least since the time of the ancient Egyptians.[7]
^Brookhiser R (2008). Gentleman Revolutionary: Gouverneur Morris, the Rake Who Wrote the Constitution. Simon and Schuster. p. 212. ISBN 978-1-4391-0408-8.
^Haslam F (1996). From Hogarth to Rowlandson: medicine in art in eighteenth-century Britain (1. publ. ed.). Liverpool: Liverpool University Press. p. 143. ISBN 978-0-85323-640-5.
^ abcdefghijklCite error: The named reference Dalbeth2016 was invoked but never defined (see the help page).
^ abcdefgHui M, Carr A, Cameron S, et al. (26 May 2017). "The British Society for Rheumatology Guideline for the Management of Gout". Rheumatology. 56 (7): e1–e20. doi:10.1093/rheumatology/kex156. PMID 28549177.
^ abBeyl RN Jr, Hughes L, Morgan S (2016). "Update on Importance of Diet in Gout". The American Journal of Medicine. 129 (11): 1153–1158. doi:10.1016/j.amjmed.2016.06.040. PMID 27452679.
^Neogi T (July 2016). "Gout". Annals of Internal Medicine (Review). 165 (1): ITC1-16. doi:10.7326/AITC201607050. PMID 27380294.
^Qaseem A, Harris RP, Forciea MA, et al. (3 January 2017). "Management of Acute and Recurrent Gout: A Clinical Practice Guideline From the American College of Physicians". Annals of Internal Medicine. 166 (1): 58–68. doi:10.7326/m16-0570. PMID 27802508.
^"Gout | Definition of Gout by Lexico". Lexico Dictionaries | English. Archived from the original on 19 October 2019. Retrieved 20 October 2019.
^Abhishek A, Roddy E, Doherty M (February 2017). "Gout - a guide for the general and acute physicians". Clinical Medicine. 17 (1): 54–59. doi:10.7861/clinmedicine.17-1-54. PMC 6297580. PMID 28148582.
^Schlesinger N (March 2010). "Diagnosing and treating gout: a review to aid primary care physicians". Postgrad Med. 122 (2): 157–161. doi:10.3810/pgm.2010.03.2133. PMID 20203467. S2CID 35321485.
^"Definition of Podagra". www.merriam-webster.com. Retrieved 19 January 2023.
^Shekelle PG, Newberry SJ, Fitzgerald JD, et al. (2017). "Management of Gout: A Systematic Review in Support of an American College of Physicians Clinical Practice Guideline". Annals of Internal Medicine. 166 (1): 37–51. doi:10.7326/M16-0461. PMID 27802478.
^"Questions and Answers about Gout". National Institute of Arthritis and Musculoskeletal and Skin Diseases. June 2015. Archived from the original on 15 January 2016. Retrieved 2 February 2016.
^Roddy E, Choi HK (May 2014). "Epidemiology of gout". Rheumatic Disease Clinics of North America. 40 (2): 155–175. doi:10.1016/j.rdc.2014.01.001. PMC 4119792. PMID 24703341.
^"Rich Man's Disease – definition of Rich Man's Disease in the Medical dictionary". Free Online Medical Dictionary, Thesaurus and Encyclopedia.
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