Region of sexual chromosomes exhibiting an autosomal inheritance pattern
Detail of a human metaphase spread. A region in the pseudoautosomal region of the short arms of the X chromosome (left) and the Y chromosome (top right) was detected by fluorescent in situ hybridization (green). Chromosomes counterstained in red.
The pseudoautosomal regions, PAR1, PAR2,[1] are homologous sequences of nucleotides on the X and Y chromosomes.
The pseudoautosomal regions get their name because any genes within them (so far at least 29 have been found for humans)[2] are inherited just like any autosomal genes. PAR1 comprises 2.6 Mbp of the short-arm tips of both X and Y chromosomes in humans and great apes (X and Y are 154 Mbp and 62 Mbp in total). PAR2 is at the tips of the long arms, spanning 320 kbp.[3]
^Mangs, Helena; Morris BJ (2007). "The Human Pseudoautosomal Region (PAR): Origin, Function and Future". Current Genomics. 8 (2): 129–136. doi:10.2174/138920207780368141. PMC 2435358. PMID 18660847.
^Blaschke RJ, Rappold G (2006). "The pseudoautosomal regions, SHOX and disease". Curr Opin Genet Dev. 16 (3): 233–9. doi:10.1016/j.gde.2006.04.004. PMID 16650979.
^Helena Mangs A, Morris BJ (April 2007). "The Human Pseudoautosomal Region (PAR): Origin, Function and Future". Curr. Genomics. 8 (2): 129–36. doi:10.2174/138920207780368141. PMC 2435358. PMID 18660847.
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The pseudoautosomal regions, PAR1, PAR2, are homologous sequences of nucleotides on the X and Y chromosomes. The pseudoautosomal regions get their name...
identical, and only exchange information over a small region of homology called the pseudoautosomalregion. Multiple recombination nodules are distinctly visible...
meiosis. However, in males, the X and Y pair in a shared region known as the pseudoautosomalregion (PAR). The PAR undergoes frequent recombination between...
(5 ft 4+1⁄8 in). The increased gene dosage of three X/Y chromosome pseudoautosomalregion (PAR1) SHOX genes has been postulated as a cause of the increased...
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Schumann E, Weber WE (June 2003). "Sex-linked AFLP markers indicate a pseudoautosomalregion in hemp ( Cannabis sativa L.)". Theoretical and Applied Genetics...
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