Genetic condition in which a male has an extra Y chromosome
Not to be confused with XXY (2 Xs, Klinefelter syndrome).
"Xyy" redirects here. For the color model, see XyY. For the series of novels, see The XYY Man.
Medical condition
XYY syndrome
Other names
47,XYY[1]
Karyotype from a male with 47,XYY
Specialty
Medical genetics
Symptoms
None, being taller than the parents, Mildly unusual physical features, severe acne, poor coordination, weak muscle tone, learning and speech problems[1][2]
XYY syndrome, also known as Jacobs syndrome, is an aneuploid genetic condition in which a male has an extra Y chromosome.[1] There are usually few symptoms.[2] These may include being taller than average and an increased risk of learning disabilities.[1][2] The person is generally otherwise normal, including typical rates of fertility.[1]
The condition is generally not inherited but rather occurs as a result of a random event during sperm development.[1] Diagnosis is by a chromosomal analysis, but most of those affected are not diagnosed within their lifetime.[2] There are 47 chromosomes, instead of the usual 46, giving a 47,XYY karyotype.[1]
Treatment may include speech therapy or extra help with schoolwork, however outcomes are generally positive.[2] The condition occurs in about 1 in 1,000 male births.[1] Many people with the condition are unaware that they have it.[4] The condition was first described in 1961.[5]
^ abcdefghi"47,XYY syndrome". Genetics Home Reference. January 2009. Retrieved 2017-03-19.
^ abcdefghij"XYY Syndrome". NORD (National Organization for Rare Disorders). 2012. Retrieved 11 November 2017.
^"XYY Syndrome".
^ ab"47, XYY syndrome". Genetic and Rare Diseases Information Center (GARD). 2017. Archived from the original on 11 November 2017. Retrieved 11 November 2017.
^Bostwick, David G.; Cheng, Liang (2014). Urologic Surgical Pathology E-Book. Elsevier Health Sciences. p. 682. ISBN 978-0-323-08619-6.
XYYsyndrome, also known as Jacobs syndrome, is an aneuploid genetic condition in which a male has an extra Y chromosome. There are usually few symptoms...
cases. The presentation of the syndrome is heterogeneous, but appears to be more severe than its counterpart XYYsyndrome. Common traits include borderline...
were found to have an extra Y chromosome, the XYYsyndrome. Jacobs hypothesized that men with XYYsyndrome are more prone to aggressive and violent behavior...
Aneuploidy Intersex Turner syndromeXYYsyndrome XXYY syndrome Taurodontism Trisomy X "What are common symptoms of Klinefelter syndrome (KS)?". Eunice Kennedy...
syndrome in 1960, and XYY and tetrasomy X in 1961. The 49,XXXYY karyotype was not reported again until 1974, highlighting the rarity of the syndrome....
stature in Turner syndrome and its counterpoint, tall stature in sex chromosome polysomy conditions such as Klinefelter syndrome, XYYsyndrome, and trisomy...
Down syndrome or Down's syndrome, also known as trisomy 21, is a genetic disorder caused by the presence of all or part of a third copy of chromosome...
trisomy X and Turner syndrome in Denmark Violin plots of age at diagnosis for Klinefelter syndrome, trisomy X, and XYYsyndrome The first known case of...
include chromosomal disorders such as Down syndrome, Klinefelter syndrome, XYYsyndrome and fragile X syndrome. Acquired causes of tics include drug-induced...
XY/47,XXY), or structural chromosome abnormalities. The incidence of XYYsyndrome is approximately 1 in 800–1000 male births. Many cases remain undiagnosed...
males are born two Xs and a Y ("XXY", see Klinefelter syndrome), one X and two Ys (see XYYsyndrome). Some females have three Xs (Trisomy X), and some have...
adults with XYYYY syndrome have been described. The disorder's prevalence is estimated to be below 1 in 1,000,000. XYYsyndrome XYYY syndrome While some writers...
as newborn screening allowed for major conditions such as XYYsyndrome, Klinefelter syndrome, and trisomy X to be re-defined by more representative phenotypes;...
Klinefelter syndrome, as Harry Klinefelter had already diagnosed the symptoms in 1942. Despite her work being on XXY syndrome, the XYYsyndrome is instead...
Ure separated in 1989. Giles had a son who was born with XYYsyndrome and Asperger syndrome; in 2011, having written a blog outlining the difficulties...
include chromosomal disorders such as Down syndrome, Klinefelter syndrome, XYYsyndrome and fragile X syndrome. Acquired causes of tics include drug-induced...
include chromosomal disorders such as Down syndrome, Klinefelter syndrome, XYYsyndrome, and fragile X syndrome. Acquired causes of tics include drug-induced...
Turner's syndrome - a single X chromosome is present, Klinefelter's syndrome - two X chromosomes and a Y chromosome are present, XYYsyndrome and XXYY...
Helmet" facial features, and mild to profound mental health problems. XYYsyndrome. XYY boys are usually taller than their siblings. Like XXY boys and XXX...
The XYY Man began as a series of novels by Kenneth Royce, featuring the character of William (or Willie) 'Spider' Scott, a one-time cat-burglar who leaves...
as limb anomalies, syndromes involving multiple systems, and Down syndrome. Recent studies have concluded that 5-9% of Down syndrome cases are due to paternal...
generally do not come in pairs. Every human male (excepting those with XYYsyndrome) has only one copy of that chromosome. This means that there is not any...
techniques that he had learned in the Spanish Foreign Legion. Diagnosed with XYYsyndrome and interned in a mental institution until his death in 1998. Ershad...
and is associated with Klinefelter syndrome, Tricho-dento-osseous syndrome, Triple X syndrome, and XYYsyndrome. Hypercementosis is excessive formation...
genes that are missing in individuals with Williams-Beuren syndrome. Also so called XYYsyndrome can often cause speech delay. Twins Being a twin increases...
feature of rare genetic disorders such as Apert's syndrome. Severe acne may be associated with XYYsyndrome. Hormonal activity, such as occurs during menstrual...
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