Properdin is a protein that in humans is encoded by the CFP (complement factor properdin) gene.
Properdin is plasma glycoprotein that activates the complement system of the innate immune system. This protein binds to bacterial cell walls and dying human cells to stabilize the C3 and C5-convertase enzyme complexes to form an attack complex that lead to the lysis of the cell.
^ abcGRCh38: Ensembl release 89: ENSG00000126759 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000001128 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Properdin is a protein that in humans is encoded by the CFP (complement factor properdin) gene. Properdin is plasma glycoprotein that activates the complement...
Properdin deficiency is a rare X-linked disease in which properdin, an important complement factor responsible for the stabilization of the alternative...
E, WARDLAW A (1954). "The properdin system and immunity. I. Demonstration and isolation of a new serum protein, properdin, and its role in immune phenomena"...
Factor D (EC 3.4.21.46, C3 proactivator convertase, properdin factor D esterase, factor D (complement), complement factor D, CFD, adipsin) is a protein...
complex is believed to be unstable until it binds properdin, a serum protein. The addition of properdin forms the complex C3bBbP, a stable compound which...
produces all types of blood cells during fetal life Production of opsonins, properdin, and tuftsin. Release of neutrophils following myocardial infarction....
glomerulus. As soon as binding occurs to the glomerulus, via interaction with properdin, the complement is activated. Complement fixation causes the generation...
conditions, while properdin deficiency occurs through X-linked inheritance. MBL deficiency can be inherited by either manner. Properdin deficiency is an...
less complete than that of complement non-deficient persons. Inherited properdin deficiency also is related, with an increased risk of contracting meningococcal...
convertase. The C3bBb complex is stabilized by binding oligomers of factor P (properdin). The stabilized C3 convertase, C3bBbP, then acts enzymatically to cleave...
Immunofluorescence shows mesangial deposition of IgA often with C3 and properdin and smaller amounts of other immunoglobulins (IgG or IgM). Early components...
cleaved by Factor D into Factor Bb. This C3bBb convertase is stabilized by properdin (Factor P) preferentially on microbial surfaces over normal host surfaces...
ED, Kriel J (December 1995). "DBP (vitamin D binding protein) and BF (properdin factor B) allele distribution in Namibian San and Khoi and in other South...
Lachmann PJ, Harrison RA (August 1988). "Analysis of the interaction between properdin and factor B, components of the alternative-pathway C3 convertase of complement"...
the amino-terminal heparin-binding domain, the procollagen domain, the properdin-like type I repeats, and the globular carboxy-terminal domain. The protein...
conservation Louis Pillemer, (B.S. 1932), immunologist; discoverer of properdin John H. Sampson (Ph.D. 1996, M.B.A. 2011), world-renowned neurosurgeon...
(2015-01-07). "A War with the Molecules: Louis Pillemer and the History of Properdin". Perspectives in Biology and Medicine. 23 (4): 638–657. doi:10.1353/pbm...
absence of recurrent pyogenic infection or features of lupus. They excluded properdin deficiency, which can be accompanied by susceptibility to meningococcal...
to low levels of complement component 3 (C3), factor B, factor H and properdin in blood, due to unregulated activation of C3 convertase, and to low levels...
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