Components of phosphatidylserines: Blue, green: variable fatty acid groups Black: glycerol Red: phosphate Purple: serine
Identifiers
CAS Number
1446756-47-3Y
ChEBI
CHEBI:18303Y
ChemSpider
none
DrugBank
DB00144N
KEGG
C02737
UNII
394XK0IH40Y
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references
Chemical compound
Phosphatidylserine (abbreviated Ptd-L-Ser or PS) is a phospholipid and is a component of the cell membrane.[1] It plays a key role in cell cycle signaling, specifically in relation to apoptosis. It is a key pathway for viruses to enter cells via apoptotic mimicry.[2] Its exposure on the outer surface of a membrane marks the cell for destruction via apoptosis.
^Kannan, Muthukumar; Riekhof, Wayne R.; Voelker, Dennis R. (2015). "Transport of Phosphatidylserine from the Endoplasmic Reticulum to the Site of Phosphatidylserine Decarboxylase2 in Yeast". Traffic. 16 (2): 123–134. doi:10.1111/tra.12236. ISSN 1600-0854. PMID 25355612.
^Meertens L, Carnec X, Lecoin MP, Ramdasi R, Guivel-Benhassine F, Lew E, Lemke G, Schwartz O, Amara A (October 2012). "The TIM and TAM families of phosphatidylserine receptors mediate dengue virus entry". Cell Host & Microbe. 12 (4): 544–57. doi:10.1016/j.chom.2012.08.009. PMC 3572209. PMID 23084921.
and 27 Related for: Phosphatidylserine information
Phosphatidylserine (abbreviated Ptd-L-Ser or PS) is a phospholipid and is a component of the cell membrane. It plays a key role in cell cycle signaling...
Phosphatidylserine decarboxylase is the enzyme that is used to decarboxylate phosphatidylserine in the first pathway. The phosphatidylserine decarboxylation...
The enzyme phosphatidylserine decarboxylase (EC 4.1.1.65) catalyzes the chemical reaction phosphatidyl-L-serine ⇌ {\displaystyle \rightleftharpoons }...
functions. PhosphatidylserinePhosphatidylserine is important in cell signaling, specifically apoptosis. Cells will use this phosphatidylserine to enter...
Phosphatidylserine synthase 1 is a protein that in humans is encoded by the PTDSS1 gene. The protein encoded by this gene catalyzes the formation of phosphatidylserine...
commonly used to detect apoptotic cells by its ability to bind to phosphatidylserine, a marker of apoptosis when it is on the outer leaflet of the plasma...
"Transport of Phosphatidylserine from the Endoplasmic Reticulum to the Site of Phosphatidylserine Decarboxylase2 in Yeast: Phosphatidylserine Transport to...
asymmetry, in particular the appearance of the anionic phospholipid phosphatidylserine on the exoplasmic face, can serve as an early indicator of apoptosis...
phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine, and phosphatidic acid. Lecithin was first isolated in 1845 by the...
crucial role in blood clotting. In the bilayer of red blood cells is phosphatidylserine. This is usually in the cytoplasmic side of the membrane. However...
serves as a ligand for TIM-1 but also as a receptor for phosphatidylserine. Its phosphatidylserine binding however does not mediate signalling instead it...
intracellular molecules on the cell surface, such as calreticulin, phosphatidylserine (from the inner layer of the plasma membrane), annexin A1, oxidised...
to signal to the reticuloendothelial phagocytes by externalizing phosphatidylserine, it is likely to lyse through uncontrolled means. The distinguishing...
and the response of rhodopsin contained in the synaptic vesicles. Phosphatidylserine (PS) – which contains high DHA content – has roles in neuronal signaling...
Bavituximab (PGN401) is a human-mouse chimeric monoclonal antibody against phosphatidylserine, which is a component of cell membranes that is exposed when a cell...
phospholipid phosphatidylserine on their surface and act as catalysts to induce the coagulation cascade. Surface exposure of phosphatidylserine is thought...
apoptosis display phagocytotic molecules, such as phosphatidylserine, on their cell surface. Phosphatidylserine is normally found on the inner leaflet surface...
PC, GPCho or lecithin), phosphatidylethanolamine (PE or GPEtn) and phosphatidylserine (PS or GPSer). In addition to serving as a primary component of cellular...
centuries. White beans are the most abundant plant-based source of phosphatidylserine (PS) currently known. It contains notably high levels of apigenin...
removed after phagocytosis of pathogens by macrophages. PECAM-1 and phosphatidylserine on the cell surface are involved in this process. Neutrophils undergo...
diphosphate-diacylglycerol. Its hydroxyl group reacts with serine to form phosphatidylserine which decarboxylates to ethanolamine and phosphatidylethanolamine...
Phosphatidylethanolamine (PE); Phosphoinositol (PI) (small amounts). Phosphatidylserine (PS); This asymmetric phospholipid distribution among the bilayer...
accelerator at CERN Chloropicrin, a highly toxic chemical compound Phosphatidylserine, a phospholipid Phosphorothioate (or thiophosphate), a family of compounds...
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