Pethidine intermediate A is a 4-phenylpiperidine derivative that is a precursor to the opioid analgesic drug pethidine (meperidine). It is not known to have any analgesic activity in its own right, however other derivatives of pethidine with a 4-cyano group in place of the carboxylate ethyl ester have been found to be active,[2] so pethidine intermediate A might also show opioid effects. It is scheduled by UN Single Convention on Narcotic Drugs. It is a Schedule II Narcotic controlled substance in the United States and has an ACSCN of 9232. The 2014 annual manufacturing quota was 6 grammes (as an end product, presumably for research use).[3]
^Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
^Lomenzo SA, Rhoden JB, Izenwasser S, Wade D, Kopajtic T, Katz JL, Trudell ML (March 2005). "Synthesis and biological evaluation of meperidine analogues at monoamine transporters". Journal of Medicinal Chemistry. 48 (5): 1336–43. doi:10.1021/jm0401614. PMID 15743177.
^"Conversion Factors for Controlled Substances". Diversion Control Division. Drug Enforcement Agency, U.S. Department of Justice.
and 27 Related for: Pethidine intermediate A information
PethidineintermediateA is a 4-phenylpiperidine derivative that is a precursor to the opioid analgesic drug pethidine (meperidine). It is not known to...
Pethidine, also known as meperidine and sold under the brand name Demerol among others, is a fully synthetic opioid pain medication of the phenylpiperidine...
(normeperidine, pethidineintermediate B) is a 4-phenylpiperidine derivative that is both a precursor to, and the toxic metabolite of, pethidine (meperidine)...
(meperidinic acid, pethidineintermediate C) is a 4-phenylpiperidine derivative that is both a metabolite of and a precursor to pethidine (meperidine). It...
Oxymorphone Para-fluorofentanyl PEPAP PethidinePethidineintermediateAPethidineintermediate B Pethidineintermediate C Phenadoxone Phenampromide Phenazocine...
synthetic opioids had been developed, including drugs related to methadone, pethidine (meperidine/Demerol), morphinans, and dextromoramide (Palfium, Palphium...
a Schedule I drug in the United States. It is an analog of pethidine (meperidine) a Schedule II drug. Chemically, it is a reversed ester of pethidine...
mass : 200.279 g/mol) may refer to: Dexmedetomidine Medetomidine PethidineintermediateA PNU-22394 RU-28306 Tetrahydrozoline This set index page lists chemical...
Trimeperidine (1,2,5-trimethyl-4-phenyl-4-piperidinol propionate) PethidineIntermediate C (1-methyl-4-phenylpiperidine-4-carboxylate) but not including:...
requires a prescription from a licensed practitioner. Waters AB (1947). "Pethidine In Labour". The British Medical Journal. 2 (4514): 71–72. doi:10.1136/bmj...
produced during the manufacture of MPPP, a synthetic opioid drug with effects similar to those of morphine and pethidine (meperidine). The Parkinson-inducing...
hydrocodone, dihydromorphine, pethidine) all exert a similar influence on the cerebral opioid receptor system. Buprenorphine is a partial agonist of the μ-opioid...
fentanyl, morphine, heroin and methadone (the notable exception being pethidine) Products containing nicotine such as cigarettes, chewing tobacco or gum...
side chain carbon, simultaneously forming a carbinolamine intermediate on the THF and a quinoid intermediate with the PLP. However, THF is not an obligate...
preservative-free local anesthetic agents may be injected intrathecally. Pethidine also has local anesthetic properties, in addition to its opioid effects...
subjects when compared to both methadone and pethidine. In comparison to equianalgesic doses of pethidine (Demerol), methadone was shown to produce less...
recognized as safe for use in human food". Glycine is an intermediate in the synthesis of a variety of chemical products. It is used in the manufacture...
French surgeon Pierre Huguenard used promethazine together with pethidine as part of a cocktail to induce relaxation and indifference in surgical patients...
such as phenobarbital, were long used as anxiolytics and hypnotics. Intermediate-acting barbiturates reduce time to fall asleep, increase total sleep...
acetoacetate under basic conditions and methylation of the resulting intermediate compound 1-phenyl-3-methylpyrazolone with dimethyl sulfate or methyl...
(CDP-Choline) or cytidine 5'-diphosphocholine is an intermediate in the generation of phosphatidylcholine from choline, a common biochemical process in cell membranes...
Global Information
