Morpheridine information

Morpheridine
Clinical data
ATC code	none;
Legal status
Legal status	AU: S9 (Prohibited substance); BR: Class A1 (Narcotic drugs); CA: Schedule I; DE: Anlage I (Authorized scientific use only); UK: Controlled Drug; US: Schedule I; UN: Psychotropic Schedule I;
Identifiers
	IUPAC name ethyl 1-(2-morpholin-4-ylethyl)-4-phenyl-piperidine-4-carboxylate;
CAS Number	469-81-8 ;
PubChem CID	61121;
ChemSpider	55069 ;
UNII	1854GKB41Y;
CompTox Dashboard (EPA)	DTXSID20196979 ;
ECHA InfoCard	100.006.749
Chemical and physical data
Formula	C20H30N2O3
Molar mass	346.471 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(OCC)C3(c1ccccc1)CCN(CCN2CCOCC2)CC3;
	InChI InChI=1S/C20H30N2O3/c1-2-25-19(23)20(18-6-4-3-5-7-18)8-10-21(11-9-20)12-13-22-14-16-24-17-15-22/h3-7H,2,8-17H2,1H3 ; Key:JDEDMCKQPKGSAX-UHFFFAOYSA-N ;
	(verify)

Morpheridine (Morpholinoethylnorpethidine)^[2] is a 4-phenylpiperidine derivative that is related to the clinically used opioid analgesic drug pethidine (meperidine). It is a strong analgesic with around 4 times the potency of pethidine,^[3] and unlike pethidine, does not cause convulsions, although it produces the standard opioid side effects such as sedation and respiratory depression.^[4]

Morpheridine is not currently used in medicine and is a Schedule I drug which is controlled under UN drug conventions.^[5]

^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
^ US 2795581, Stern ES, Anderson RJ, "Piperidine Compounds and Their Production", issued 06/11/1957, assigned to J.F. McFarlan & Co
^ Holmes JM (February 1958). "Morpholinoethylnorpethidine hydrochloride in obstetrics". The Journal of Obstetrics and Gynaecology of the British Empire. 65 (1): 98–9. doi:10.1111/j.1471-0528.1958.tb06218.x. PMID 13514558. S2CID 1481693.
^ Green AF, Ward NB (March 1956). "Analgesic and other properties of morpholinoethylnorpethidine". British Journal of Pharmacology and Chemotherapy. 11 (1): 32–4. doi:10.1111/j.1476-5381.1956.tb01023.x. PMC 1509567. PMID 13304251.
^ "Single convention on drugs 1961".

[1] Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.

[2] US 2795581, Stern ES, Anderson RJ, "Piperidine Compounds and Their Production", issued 06/11/1957, assigned to J.F. McFarlan & Co

[3] Holmes JM (February 1958). "Morpholinoethylnorpethidine hydrochloride in obstetrics". The Journal of Obstetrics and Gynaecology of the British Empire. 65 (1): 98–9. doi:10.1111/j.1471-0528.1958.tb06218.x. PMID 13514558. S2CID 1481693.

[4] Green AF, Ward NB (March 1956). "Analgesic and other properties of morpholinoethylnorpethidine". British Journal of Pharmacology and Chemotherapy. 11 (1): 32–4. doi:10.1111/j.1476-5381.1956.tb01023.x. PMC 1509567. PMID 13304251.

[5] "Single convention on drugs 1961".

Morpheridine information

and 11 Related for: Morpheridine information

Morpheridine

Opioid

Brazilian Controlled Drugs and Substances Act

Drug policy of India

Single Convention on Narcotic Drugs

List of compounds with carbon number 20

Norpethidine

Opium Law

Controlled Drugs and Substances Act

Misuse of Drugs Act 1977

List of opioids

Clinical data

ATC code	none
Legal status
Legal status	AU: S9 (Prohibited substance) BR: Class A1 (Narcotic drugs)^[1] CA: Schedule I DE: Anlage I (Authorized scientific use only) UK: Controlled Drug US: Schedule I UN: Psychotropic Schedule I
Identifiers
IUPAC name ethyl 1-(2-morpholin-4-ylethyl)-4-phenyl-piperidine-4-carboxylate
CAS Number	469-81-8^Y
PubChem CID	61121
ChemSpider	55069^Y
UNII	1854GKB41Y
CompTox Dashboard (EPA)	DTXSID20196979
ECHA InfoCard	100.006.749
Chemical and physical data
Formula	C₂₀H₃₀N₂O₃
Molar mass	346.471 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=C(OCC)C3(c1ccccc1)CCN(CCN2CCOCC2)CC3
InChI InChI=1S/C20H30N2O3/c1-2-25-19(23)20(18-6-4-3-5-7-18)8-10-21(11-9-20)12-13-22-14-16-24-17-15-22/h3-7H,2,8-17H2,1H3^Y Key:JDEDMCKQPKGSAX-UHFFFAOYSA-N^Y
(verify)