Paroxysmal extreme pain disorder originally named familial rectal pain syndrome, is a rare disorder whose most notable features are pain in the mandibular, ocular and rectal areas as well as flushing. PEPD often first manifests at the beginning of life, perhaps even in utero, with symptoms persisting throughout life. PEPD symptoms are reminiscent of primary erythromelalgia, as both result in flushing and episodic pain, though pain is typically present in the extremities for primary erythromelalgia. Both of these disorders have recently been shown to be allelic, both caused by mutations in the voltage-gated sodium channel NaV1.7 encoded by the gene SCN9A. A different mutation in the SCN9A ion channel causes congenital insensitivity to pain.
and 26 Related for: Paroxysmal extreme pain disorder information
Paroxysmalextremepaindisorder originally named familial rectal pain syndrome, is a rare disorder whose most notable features are pain in the mandibular...
cause of facial pain. Neuralgia refers to pain in the distribution of a nerve (or nerves), and commonly implies paroxysmal (sudden) pain, although the accepted...
Dystonia is a neurological hyperkinetic movement disorder in which sustained or repetitive muscle contractions occur involuntarily, resulting in twisting...
Paroxysmal cold hemoglobinuria (PCH) or Donath–Landsteiner hemolytic anemia (DLHA) is an autoimmune hemolytic anemia featured by complement-mediated intravascular...
most common type of dizziness. The most common disorders that result in vertigo are benign paroxysmal positional vertigo (BPPV), Ménière's disease, and...
prescribed in the management of anxiety disorders, especially panic disorder and generalized anxiety disorder (GAD). Other uses include the treatment...
of sudden cardiac death. As of 2013, cardiomyopathies are defined as "disorders characterized by morphologically and functionally abnormal myocardium...
Oculogyric crisis (OGC) is a rare sudden, paroxysmal, dystonic reaction that may manifest in response to specific drugs, particularly neuroleptics, or...
later identified to be an epilepsy syndrome. Attacks of the movement disorderparoxysmal dyskinesia may be taken for epileptic seizures. The cause of a drop...
Narcolepsy is a chronic neurological disorder that impairs the ability to regulate sleep–wake cycles, and specifically impacts REM (rapid eye movement)...
caused by pathologically activated eosinophilic white blood cells. This disorder differs from myocarditis in its causes and treatments. Valvular heart disease...
studies defining PEP solely as pain in the amputated eye. Frequency and characteristics of PEP vary, with paroxysmal episodes lasting for a few seconds...
increased levels of DA in the Parkinsonian brain... Lump D, Moyer M (2014). "Paroxysmal sympathetic hyperactivity after severe brain injury". Current Neurology...
experienced "hysterical paroxysm" (i.e., orgasm). Paroxysm was regarded as a medical treatment, and not a sexual release. The disorder has ceased to be recognized...
others". It is no longer recognized by medical authorities as a medical disorder. Its diagnosis and treatment were routine for hundreds of years in Western...
skin ulcers. Chronic pain is common and harder to treat.[citation needed] Trigeminal neuralgia (or "tic douloureux") is a disorder of the trigeminal nerve...
1976, and he named the condition several years later. REM sleep behavior disorder (RBD)—in which people lose the muscle paralysis (atonia) that normally...
23-year-old nursing student, Angel Parker, experiences episodes of extreme muscle fatigue, pain and cramping after prolonged exercise, sometimes followed by...
Global Information