Paired box gene 2, also known as Pax-2, is a protein which in humans is encoded by the PAX2 gene.[5][6]
^ abcGRCh38: Ensembl release 89: ENSG00000075891 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000004231 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Pilz AJ, Povey S, Gruss P, Abbott CM (1993). "Mapping of the human homologs of the murine paired-box-containing genes". Mammalian Genome. 4 (2): 78–82. doi:10.1007/BF00290430. PMID 8431641. S2CID 30845070.
^Stapleton P, Weith A, Urbánek P, Kozmik Z, Busslinger M (Apr 1993). "Chromosomal localization of seven PAX genes and cloning of a novel family member, PAX-9". Nature Genetics. 3 (4): 292–8. doi:10.1038/ng0493-292. PMID 7981748. S2CID 21338655.
gene 2, also known as Pax-2, is a protein which in humans is encoded by the PAX2 gene. The Pax Genes, or Paired-Box Containing Genes, play important roles...
known as Fuchs coloboma. Coloboma can be associated with a mutation in the PAX2 gene. Eye abnormalities have been shown to occur in over 90% of children...
stalk causes optic disc dysplasia, which is caused by a mutation in the Pax2 gene. The nerve head typically resembles the morning glory disc anomaly,...
development of the fallopian tubes include the Wnt and Hox groups of genes, Lim1, Pax2, and Emx2. Embryos have two pairs of ducts that will let gametes out of the...
induction include the odd-skipped related gene (Osr1) and paired-box-2 gene (Pax2) which require intermediate levels of BMP signalling to activate Markers...
cancers. Tamoxifen seems to require a protein PAX2 for its full anticancer effect. In the presence of high PAX2 expression, the tamoxifen/ER complex is able...
question occur at EYA1 or SIX1 genes (branchio-oto-renal syndrome). The PAX2 gene is also thought to play a role in MCDK. The contralateral kidney often...
this condition is in the mutations in kidney-related genes, namely, HNF1B, PAX2, PBX1. However, environmental factors like maternal diseases such as diabetes...
when the ratio of the coactivator AIB-3 exceeds that of the corepressor PAX2, the expression of HER2 is upregulated in the presence of tamoxifen, leading...
structures such as the cochlea is regulated by Dlx5/Dlx6, Otx1/Otx2 and Pax2, which in turn are controlled by the master gene Shh. Shh is secreted by...
since it is not clear that they are "drugable" but progress has been made on Pax2 and the notch pathway. Gene duplications have played a crucial role in the...
LZ (March 1999). "Characterization of an amphioxus paired box gene, AmphiPax2/5/8: developmental expression patterns in optic support cells, nephridium...
formation of the Mullerian duct is regulated by sequential actions of BMP/Pax2 and FGF/Lim1 signaling". Development. 143 (19): 3549–3559. doi:10.1242/dev...
assists nuclear receptors in the upregulation of gene expression. The ratio of PAX2 to AIB-1 protein expression may be predictive of the effectiveness of tamoxifen...
has been linked to undulated mutant suffering from skeletal malformations. PAX2 has been identified with kidney and optic nerve development. It transcribes...
Orofaciodigital syndrome type VI LRP5 AR Osteoporosis-pseudoglioma syndrome PAX2 AD Papillorenal syndrome ATOH7 AR Persistent fetal vasculature (PFV)/persistent...
ear structures is determined by homeobox transcription factors including PAX2, DLX5 and DLX6, with the former specifying for ventral otic vesicle derived...
utility of potential biomarkers of tamoxifen responsiveness such as HOXB13, PAX2, and estrogen receptor (ER) alpha and beta isoforms interaction with SRC3...
implicated in Alzheimer's disease. PAXIP1 has been shown to interact with PAX2 and TP53BP1. GRCh38: Ensembl release 89: ENSG00000157212 – Ensembl, May 2017...
Global Information
