carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
Dihydroorotase (fragment) dimer, Human
Identifiers
Symbol
CAD
NCBI gene
790
HGNC
1424
OMIM
114010
RefSeq
NM_004341
UniProt
P27708
Other data
EC number
3.5.2.3
Locus
Chr. 2 p22-p21
Search for
Structures
Swiss-model
Domains
InterPro
Dihydroorotase (EC 3.5.2.3, carbamoylaspartic dehydrase, dihydroorotate hydrolase) is an enzyme which converts carbamoyl aspartic acid into 4,5-dihydroorotic acid in the biosynthesis of pyrimidines.[1][2] It forms a multifunctional enzyme with carbamoyl phosphate synthetase and aspartate transcarbamoylase. Dihydroorotase is a zinc metalloenzyme.[3]
^Cooper C, Wilson DW (1954). "Biosynthesis of pyrimidines". Fed. Proc. 13: 194.
^Lieberman I, Kornberg A (April 1954). "Enzymatic synthesis and breakdown of a pyrimidine, orotic acid. I. Dihydroortic acid, ureidosuccinic acid, and 5-carboxymethylhydantoin" (PDF). The Journal of Biological Chemistry. 207 (2): 911–24. doi:10.1016/S0021-9258(18)65708-4. PMID 13163076.
^Voet, Donald (2011). Biochemistry. Judith G. Voet. Hoboken, NJ: John Wiley & Sons. ISBN 978-0-470-57095-1. OCLC 690489261.
Dihydroorotase (EC 3.5.2.3, carbamoylaspartic dehydrase, dihydroorotate hydrolase) is an enzyme which converts carbamoyl aspartic acid into 4,5-dihydroorotic...
carbamoyl phosphate synthetase II, aspartate carbamoyltransferase and dihydroorotase. Dihydroorotate dehydrogenase (DHODH) unlike CAD and UMPS is a mono-functional...
carbamoyl aspartic acid, which is cyclized into 4,5-dihydroorotic acid by dihydroorotase. The latter is converted to orotate by dihydroorotate oxidase. The net...
synthesis of the pyrimidine nucleotides: carbamoyl phosphate synthase, dihydroorotase, aspartate carbamoyltransferase. This must have involved a double fusion...
opisthokonts have a triple fusion of carbamoyl phosphate synthetase, dihydroorotase, and aspartate carbamoyltransferase that is not present in plants, and...
Evans DR (Jan 1990). "Mammalian dihydroorotase: nucleotide sequence, peptide sequences, and evolution of the dihydroorotase domain of the multifunctional...
(carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase) is a trifunctional multi-domain enzyme involved in the first three...
undergoing a condensation reaction with carbamoyl phosphate. Dihydroorotase and dihydroorotase dehydrogenase then converts N-Carbamoylaspartate to orotate...
condenses carbamoyl phosphate with aspartate to form uridosuccinate. Dihydroorotase performs ring closure, a reaction that loses water, to form dihydroorotate...
at the 5' of the PyrC mRNA in Enterobacteria. The PyrC gene encodes Dihydroorotase, an enzyme involved in pyrimidine biosynthesis. The PyrC leader regulates...
binds and activates catalysis by its enzyme counterpart, SOD1 Pseudo-dihydroorotase Regulating folding or complex assembly of conventional enzyme Pseudomonas...
binding carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (CAD), an enzyme required for de novo pyrimidine nucleotide synthesis...
diaminopimelate decarboxylase (lysA), transhydrogenase alpha subunit (pntA), dihydroorotase (pyrC) and tryptophanase (tnaA). Thus both the number and type of housekeeping...
respectively. The subunit FwdA contains two zinc atoms analogous to dihydroorotase. It also contains N6-carboxylysine, zinc ligands, and an aspartate that...
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