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Stuart Schreiber information


Stuart L. Schreiber
Born (1956-02-06) February 6, 1956 (age 68)
Alma materUniversity of Virginia
Harvard University
Known forOrganic Synthesis
Chemical Biology
Human Biology
Therapeutics Discovery
AwardsArthur C. Cope Award (2015)
Wolf Prize (2016)
Scientific career
FieldsChemical Biology
InstitutionsYale University
Harvard University
Broad Institute
ThesisI: Oxidation of tertiary amines / II: Peroxides in organic synthesis (1981)
Doctoral advisorRobert Burns Woodward
Yoshito Kishi

Stuart Schreiber is an American chemist who is the Morris Loeb Research Professor at Harvard University,[1] a co-Founder of the Broad Institute,[2] Howard Hughes Medical Institute Investigator, Emeritus,[3] and a member of the National Academy of Sciences[4] and National Academy of Medicine.[5] He currently leads Arena BioWorks.

His work integrates chemical biology and human biology to advance the science of therapeutics. Key advances include the discovery that small molecules can function as “molecular glues” that promote protein–protein interactions, the co-discovery of mTOR and its role in nutrient-response signaling, the discovery of histone deacetylases and (with Michael Grunstein and David Allis) the demonstration that chromatin marks regulate gene expression, the development and application of diversity-oriented synthesis to microbial therapeutics, and the discovery of vulnerabilities of cancer cells linked to genetic, lineage and cell-state features, including ferroptotic vulnerabilities. His awards include the Wolf Prize in Chemistry and the Arthur Cope Award. His approach to discovering new therapeutics guided many biotechnology companies that he founded, including Vertex Pharmaceuticals and Ariad Pharmaceuticals. He has founded or co-founded 14 biotechnology companies, which have developed 16 first-in-human approved drugs or advanced clinical candidates.

  1. ^ "Stuart L. Schreiber". chemistry.harvard.edu. Retrieved 2023-11-29.
  2. ^ "Stuart L. Schreiber". Broad Institute. 2015-11-23. Retrieved 2023-11-29.
  3. ^ "Stuart L. Schreiber, PhD | Investigator Emeriti Profile | 1994-2018 | HHMI". www.hhmi.org. Retrieved 2023-11-29.
  4. ^ "Stuart L. Schreiber". www.nasonline.org. Retrieved 2023-11-29.
  5. ^ "The National Academy of Medicine honors Stuart Schreiber". chemistry.harvard.edu. Retrieved 2023-11-29.

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Cope rearrangement

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American Chemical Society. 97 (16): 4765–4766. doi:10.1021/ja00849a054. Schreiber, Stuart L.; Santini, Conrad (1984). "Cyclobutene bridgehead olefin route to...

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Robert Burns Woodward

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Harvard University as a doctoral researcher, where she worked alongside Stuart Schreiber on strategies to understand the interactions between proteins and molecules...

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Nutrition Science Crusade". Wired. Taubes, Gary. (April 13, 2011). Is Sugar Toxic?. The New York Times. Discusses work of Stuart Schreiber. Official website...

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Broad Institute

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synthesis, phage-assisted directed evolution and Cas9/CRISPR base-editing. Stuart Schreiber is director of the Chemical Biology program. He has developed systematic...

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Gerald Crabtree

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immune response. In the late 1980s and early 1990s Crabtree, along with Stuart Schreiber further defined the Ca2+/calcineurin/ NFAT signaling pathway, which...

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v t e ACS Chemical Biology Lectureship Alanna Schepartz (2010) Stuart Schreiber (2011) Carolyn Bertozzi (2012) Wilfred A. van der Donk (2013) Peter B....

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University of Virginia

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John Backus; polar explorer Richard Byrd; scientists Walter Reed, Stuart Schreiber, Daniel Barringer, Richard Lutz, and Francis Collins; artists Edgar...

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Wolf Prize in Chemistry

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our dominion over the interface of chemistry, biology and medicine. Stuart Schreiber  United States for pioneering chemical insights into the logic of signal...

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Stephen Liberles

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he remained in the Chemistry Department for his Ph.D., working with Stuart Schreiber. He received postdoctoral training with Linda B. Buck, where he characterized...

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Jon Clardy

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School. In 2004, he started the Ph.D. Program in Chemical Biology with Stuart Schreiber and Greg Verdine. He also created, and continues to teach, a popular...

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List of University of Virginia people

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Thomas A. Saunders III 1967 Darden Chairman of The Heritage Foundation Stuart Schreiber 1977 Col Chemical biologist; founding member of the Broad Institute...

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Ohyun Kwon

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to Harvard University as a postdoctoral fellow in the laboratory of Stuart Schreiber, where she worked on a diversity oriented synthesis of macrocycles...

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List of Clarivate Citation laureates in Physiology or Medicine

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 United States Broad Institute Massachusetts Institute of Technology Stuart Schreiber (born 1956)  United States Harvard University Howard Hughes Medical...

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Nathanael Gray

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Gray Lab permanently moved to Stanford University, that was stated by Stuart Schreiber, co-founder of Broad Institute as "Stanford's huge gain". Gray grew...

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Brent Stockwell

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completing his doctorate degree, Stockwell worked in the laboratory of Stuart Schreiber where he spent eighteen months unsuccessfully investigating a molecule...

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