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Neutrophil cytosolic factor 4 information


NCF4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNCF4, NCF, P40PHOX, SH3PXD4, Neutrophil cytosolic factor 4, CGD3
External IDsOMIM: 601488; MGI: 109186; HomoloGene: 525; GeneCards: NCF4; OMA:NCF4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000631
NM_013416

NM_008677

RefSeq (protein)

NP_000622
NP_038202

NP_032703

Location (UCSC)Chr 22: 36.86 – 36.88 MbChr 15: 78.13 – 78.15 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Neutrophil cytosol factor 4 is a protein that in humans is encoded by the NCF4 gene.[5][6]

  1. ^ a b c ENSG00000100365 GRCh38: Ensembl release 89: ENSG00000275990, ENSG00000100365 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000071715 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Zhan S, Vazquez N, Zhan S, Wientjes FB, Budarf ML, Schrock E, Ried T, Green ED, Chanock SJ (Nov 1996). "Genomic structure, chromosomal localization, start of transcription, and tissue expression of the human p40-phox, a new component of the nicotinamide adenine dinucleotide phosphate-oxidase complex". Blood. 88 (7): 2714–21. doi:10.1182/blood.V88.7.2714.bloodjournal8872714. PMID 8839867.
  6. ^ "Entrez Gene: NCF4 neutrophil cytosolic factor 4, 40kDa".

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Neutrophil extracellular traps (NETs) are networks of extracellular fibers, primarily composed of DNA from neutrophils, which bind pathogens. Neutrophils...

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producing superoxide via its redox centre, which transfers electrons from cytosolic NADPH to O2 in the phagosome. 2O2 + NADPH —> 2O2•– + NADP+ + H+ The superoxide...

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professional phagocytes include many types of white blood cells (such as neutrophils, monocytes, macrophages, mast cells, and dendritic cells). The main difference...

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has been shown to interact with: CD43 ICAM3 Neutrophil cytosolic factor 1, Neutrophil cytosolic factor 4 VCAM-1 EZR GRCh38: Ensembl release 89: ENSG00000147065...

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domains associate with the leukocyte cytoskeleton, via mediation with cytosolic factors such as talin, α-actinin and vinculin. This association causes a conformational...

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Tetratricopeptide repeat

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tripeptide PTS1 are in the concave face of TPRs 1, 2 and 3. Neutrophil cytosolic factor 2 is an essential to NADPH oxidase complex which in turn produces...

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also known as neutrophil chemotactic factor, has two primary functions. It induces chemotaxis in target cells, primarily neutrophils but also other granulocytes...

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characteristic chemoattractant effects in neutrophil granulocytes and monocytes.[citation needed] The chemotactic factor ligands and receptors related to formyl...

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Rotstein OD, et al. (May 2004). "Pre-B cell colony-enhancing factor inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis". The...

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pseudogene related to NCF1 (neutrophil cytosol factor 1), the latter being responsible for encoding the 47 kDA cytosolic subunit of NADPH oxidase. In...

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Lehrer RI (1993). "In vitro antimicrobial activity of the human neutrophil cytosolic S-100 protein complex, calprotectin, against Capnocytophaga sputigena"...

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innate immune system, such as dendritic cells, macrophages, monocytes, neutrophils and epithelial cells to identify two classes of molecules: pathogen-associated...

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Tetratricopeptide repeat domain 16 isoform 1

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directly responsible for superoxide production (known as gp91phox or Nox2), cytosolic components, responsible for the formation of the active NADPH oxidase...

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phosphorylates sphingosine to sphingosine-1-phosphate (S1P). SK1 is normally a cytosolic protein but is recruited to membranes rich in phosphatidate (PA), a product...

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them to secrete IL-8 (CXCL8) in the lamina propria, recruiting neutrophils. Neutrophil recruitment results in a very rapid onset of inflammation. Therefore...

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