S100A8 information

S100A8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1MR8, 1XK4, 4GGF, 4XJK, 5HLO, 5HLV
Identifiers
Aliases	S100A8, 60B8AG, CAGA, CFAG, CGLA, CP-10, L1Ag, MA387, MIF, MRP8, NIF, P8, S100 calcium binding protein A8, S100-A8
External IDs	OMIM: 123885; MGI: 88244; HomoloGene: 2225; GeneCards: S100A8; OMA:S100A8 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	153,391,073 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	90,577,342 bp
RNA expression pattern
	Top expressed in
	gums; ; body of tongue; ; oral cavity; ; trabecular bone; ; periodontal fiber; ; monocyte; ; bone marrow; ; vulva; ; palpebral conjunctiva; ; human penis;
	Top expressed in
	femur; ; body of femur; ; spleen; ; blood; ; olfactory epithelium; ; right lung lobe; ; left lung; ; cervix; ; left lung lobe; ; belly cord;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	Toll-like receptor 4 binding; RAGE receptor binding; microtubule binding; protein binding; calcium ion binding; arachidonic acid binding; zinc ion binding; metal ion binding;
Cellular component	nucleus; cytoskeleton; cytosol; extracellular exosome; membrane; plasma membrane; cytoplasm; extracellular space; secretory granule lumen; intermediate filament cytoskeleton; extracellular region; collagen-containing extracellular matrix;
Biological process	regulation of inflammatory response; activation of cysteine-type endopeptidase activity involved in apoptotic process; immune system process; positive regulation of inflammatory response; neutrophil chemotaxis; positive regulation of intrinsic apoptotic signaling pathway; defense response to fungus; response to ethanol; chemokine production; response to zinc ion; acute inflammatory response; defense response to bacterium; leukocyte migration involved in inflammatory response; peptidyl-cysteine S-nitrosylation; sequestering of zinc ion; neutrophil aggregation; response to lipopolysaccharide; chemotaxis; positive regulation of peptide secretion; chronic inflammatory response; astrocyte development; wound healing; apoptotic process; positive regulation of cell growth; autophagy; inflammatory response; regulation of cytoskeleton organization; cytokine production; positive regulation of NF-kappaB transcription factor activity; innate immune response; toll-like receptor signaling pathway; antimicrobial humoral response; neutrophil degranulation; autocrine signaling;
	Sources:Amigo / QuickGO
Orthologs
	6279
	20201
	ENSG00000143546
	ENSMUSG00000056054
	P05109
	P27005
	NM_002964; NM_001319196; NM_001319197; NM_001319198; NM_001319201
	NM_013650
	NP_001306125; NP_001306126; NP_001306127; NP_001306130; NP_002955
	NP_038678
	Wikidata
View/Edit Human	View/Edit Mouse

S100 calcium-binding protein A8 (S100A8) is a protein that in humans is encoded by the S100A8 gene.^[5] It is also known as calgranulin A.

The proteins S100A8 and S100A9 form a heterodimer called calprotectin.

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis ^[5] and post COVID-19 condition.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143546 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000056054 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: S100A8 S100 calcium binding protein A8".
^ Ryan FJ, Hope CM, Masavuli MG, Lynn MA, Mekonnen ZA, Yeow AE, et al. (January 2022). "Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infection". BMC Medicine. 20 (1): 26. doi:10.1186/s12916-021-02228-6. PMC 8758383. PMID 35027067.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000143546 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000056054 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: S100A8 S100 calcium binding protein A8".

[6] Ryan FJ, Hope CM, Masavuli MG, Lynn MA, Mekonnen ZA, Yeow AE, et al. (January 2022). "Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infection". BMC Medicine. 20 (1): 26. doi:10.1186/s12916-021-02228-6. PMC 8758383. PMID 35027067.

S100A8 information

and 17 Related for: S100A8 information

S100A8

Calprotectin

Faecal calprotectin

S100A9

Calgranulin

List of distinct cell types in the adult human body

Amyloid

S100 protein

EF hand

Basigin

Epidermal differentiation complex

Skin immunity

Tasquinimod

Mothers against decapentaplegic homolog 4

RNF5

NCR3

Nancy Hogg