One path neural stem cells take to reach the olfactory bulb
Rostral migratory stream
Identifiers
Acronym(s)
RMS
NeuroLex ID
birnlex_1702
Anatomical terms of neuroanatomy
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The rostral migratory stream (RMS) is a specialized migratory route found in the brain of some animals along which neuronal precursors that originated in the subventricular zone (SVZ) of the brain migrate to reach the main olfactory bulb (OB). The importance of the RMS lies in its ability to refine and even change an animal's sensitivity to smells, which explains its importance and larger size in the rodent brain as compared to the human brain, as our olfactory sense is not as developed.[2] This pathway has been studied in the rodent, rabbit, and both the squirrel monkey and rhesus monkey.[3] When the neurons reach the OB they differentiate into GABAergic interneurons as they are integrated into either the granule cell layer or periglomerular layer.
Although it was originally believed that neurons could not regenerate in the adult brain, neurogenesis has been shown to occur in mammalian brains, including those of primates. However, neurogenesis is limited to the hippocampus and SVZ, and the RMS is one mechanism neurons use to relocate from these areas.[4]
^Lennington, Jessica; Yang, Zhengang; Conover, Joanne (2003). "Neural stem cells and the regulation of adult neurogenesis". Reproductive Biology and Endocrinology. 1: 99. doi:10.1186/1477-7827-1-99. PMC 293430. PMID 14614786.
^Curtis, Maurice; Faull, Richard; Eriksson, Peter (2007). "The effect of neurodegenerative disease on the subventricular zone". Nature Reviews Neuroscience. 8 (9): 712–723. doi:10.1038/nrn2216. PMID 17704813. S2CID 12084086.
^Kam, Monica; Curtis, Maurice; McGlashan, Susan; Connor, Bronwen (2009). "The cellular composition and morphological organization of the rostral migratory stream in the adult human brain". Journal of Chemical Neuroanatomy. 37 (3): 196–205. doi:10.1016/j.jchemneu.2008.12.009. PMID 19159677. S2CID 9098496.
^Verkhratsky, Alexei; Butt, Arthur (2007). Glial Neurobiology. West Sussex: Wiley. pp. 96. ISBN 978-0-470-51740-6.
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