Furin information

FURIN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4OMC, 4OMD, 4RYD, 4Z2A
Identifiers
Aliases	FURIN, FUR, PACE, PCSK3, SPC1, furin, paired basic amino acid cleaving enzyme
External IDs	OMIM: 136950; MGI: 97513; HomoloGene: 1930; GeneCards: FURIN; OMA:FURIN - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	90,883,458 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	80,055,184 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; body of pancreas; ; right lung; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; apex of heart; ; skin of leg; ; upper lobe of left lung; ; salivary gland; ; anterior pituitary;
	Top expressed in
	epithelium of stomach; ; Ileal epithelium; ; parotid gland; ; granulocyte; ; lip; ; right kidney; ; lactiferous gland; ; corneal stroma; ; extensor digitorum longus muscle; ; secondary oocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nerve growth factor binding; peptide binding; metal ion binding; protease binding; peptidase activity; protein binding; serine-type endopeptidase inhibitor activity; serine-type peptidase activity; hydrolase activity; endopeptidase activity; serine-type endopeptidase activity;
Cellular component	integral component of membrane; Golgi apparatus; membrane; plasma membrane; cell surface; trans-Golgi network; endoplasmic reticulum; Golgi lumen; membrane raft; trans-Golgi network transport vesicle; extracellular exosome; extracellular space; Golgi membrane; extracellular region; endosome; endosome membrane; integral component of Golgi membrane;
Biological process	negative regulation of low-density lipoprotein particle receptor catabolic process; negative regulation of transforming growth factor beta1 production; viral life cycle; secretion by cell; peptide biosynthetic process; protein processing; positive regulation of membrane protein ectodomain proteolysis; extracellular matrix disassembly; extracellular matrix organization; viral protein processing; proteolysis; signal peptide processing; peptide hormone processing; regulation of signal transduction; regulation of protein catabolic process; collagen catabolic process; negative regulation of nerve growth factor production; nerve growth factor processing; nerve growth factor production; cell population proliferation; transforming growth factor beta receptor signaling pathway; regulation of endopeptidase activity; negative regulation of endopeptidase activity; cornification; zymogen activation; regulation of lipoprotein lipase activity; dibasic protein processing; zymogen inhibition; positive regulation of transforming growth factor beta1 activation;
	Sources:Amigo / QuickGO
Orthologs
	5045
	18550
	ENSG00000140564
	ENSMUSG00000030530
	P09958
	P23188
	NM_002569; NM_001289823; NM_001289824
	NM_001081454; NM_011046
NP_001276752; NP_001276753; NP_002560; NP_001369548; NP_001369549;
	NP_001369550; NP_001369551; NP_001276752.1; NP_001276753.1; NP_002560.1
	NP_001074923; NP_035176
	Wikidata
View/Edit Human	View/Edit Mouse

Furin is a protease, a proteolytic enzyme activated by substrate presentation that in humans and other animals is encoded by the FURIN gene. Some proteins are inactive when they are first synthesized, and must have sections removed in order to become active. Furin cleaves these sections and activates the proteins.^[5]^[6]^[7]^[8] It was named furin because it was in the upstream region of an oncogene known as FES. The gene was known as FUR (FES Upstream Region) and therefore the protein was named furin. Furin is also known as PACE (Paired basic Amino acid Cleaving Enzyme). A member of family S8, furin is a subtilisin-like peptidase.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000140564 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030530 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wise RJ, Barr PJ, Wong PA, Kiefer MC, Brake AJ, Kaufman RJ (December 1990). "Expression of a human proprotein processing enzyme: correct cleavage of the von Willebrand factor precursor at a paired basic amino acid site". Proceedings of the National Academy of Sciences of the United States of America. 87 (23): 9378–82. Bibcode:1990PNAS...87.9378W. doi:10.1073/pnas.87.23.9378. PMC 55168. PMID 2251280.
^ Kiefer MC, Tucker JE, Joh R, Landsberg KE, Saltman D, Barr PJ (December 1991). "Identification of a second human subtilisin-like protease gene in the fes/fps region of chromosome 15". DNA and Cell Biology. 10 (10): 757–69. doi:10.1089/dna.1991.10.757. PMID 1741956.
^ "Entrez Gene: FURIN furin (paired basic amino acid cleaving enzyme)".
^ Roebroek AJ, Schalken JA, Leunissen JA, Onnekink C, Bloemers HP, Van de Ven WJ (September 1986). "Evolutionary conserved close linkage of the c-fes/fps proto-oncogene and genetic sequences encoding a receptor-like protein". The EMBO Journal. 5 (9): 2197–202. doi:10.1002/j.1460-2075.1986.tb04484.x. PMC 1167100. PMID 3023061.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000140564 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030530 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2251280-5] Wise RJ, Barr PJ, Wong PA, Kiefer MC, Brake AJ, Kaufman RJ (December 1990). "Expression of a human proprotein processing enzyme: correct cleavage of the von Willebrand factor precursor at a paired basic amino acid site". Proceedings of the National Academy of Sciences of the United States of America. 87 (23): 9378–82. Bibcode:1990PNAS...87.9378W. doi:10.1073/pnas.87.23.9378. PMC 55168. PMID 2251280.

[pmid1741956-6] Kiefer MC, Tucker JE, Joh R, Landsberg KE, Saltman D, Barr PJ (December 1991). "Identification of a second human subtilisin-like protease gene in the fes/fps region of chromosome 15". DNA and Cell Biology. 10 (10): 757–69. doi:10.1089/dna.1991.10.757. PMID 1741956.

[entrez_5045-7] "Entrez Gene: FURIN furin (paired basic amino acid cleaving enzyme)".

[pmid3023061-8] Roebroek AJ, Schalken JA, Leunissen JA, Onnekink C, Bloemers HP, Van de Ven WJ (September 1986). "Evolutionary conserved close linkage of the c-fes/fps proto-oncogene and genetic sequences encoding a receptor-like protein". The EMBO Journal. 5 (9): 2197–202. doi:10.1002/j.1460-2075.1986.tb04484.x. PMC 1167100. PMID 3023061.

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