positive regulation of peptidyl-cysteine S-nitrosylation
regulation of cardiac muscle cell action potential
positive regulation of nitric oxide biosynthetic process
regulation of nitric-oxide synthase activity
positive regulation of delayed rectifier potassium channel activity
positive regulation of gene expression
positive regulation of nitric oxide mediated signal transduction
positive regulation of nitric-oxide synthase activity
regulation of high voltage-gated calcium channel activity
positive regulation of potassium ion transmembrane transport
regulation of heart rate by chemical signal
positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
regulation of nitric oxide biosynthetic process
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
regulation of ventricular cardiac muscle cell membrane repolarization
postsynaptic actin cytoskeleton organization
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
9722
n/a
Ensembl
ENSG00000198929
n/a
UniProt
O75052
n/a
RefSeq (mRNA)
NM_014697 NM_001126060 NM_001164757
n/a
RefSeq (protein)
NP_001119532 NP_001158229 NP_055512
n/a
Location (UCSC)
Chr 1: 162.07 – 162.37 Mb
n/a
PubMed search
[2]
n/a
Wikidata
View/Edit Human
Nitric oxide synthase 1 adaptor protein (NOS1AP) also known as carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (CAPON) is a protein that in humans is encoded by the NOS1AP gene.[3][4][5]
This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins.[5] NOS1AP polymorphisms has been associated with the QT interval length.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000198929 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, Nomura N, Ohara O (February 1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484. S2CID 263410587.
^Jaffrey SR, Snowman AM, Eliasson MJ, Cohen NA, Snyder SH (Mar 1998). "CAPON: a protein associated with neuronal nitric oxide synthase that regulates its interactions with PSD95". Neuron. 20 (1): 115–24. doi:10.1016/S0896-6273(00)80439-0. PMID 9459447. S2CID 14613261.
Nitric oxide synthase 1 adaptor protein (NOS1AP) also known as carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (CAPON) is a protein...
short QT syndrome. The QTc length is associated with variations in the NOS1AP gene. The autosomal recessive syndrome of Jervell and Lange-Nielsen is characterized...
and air pollution exposure. NOS1 has been shown to interact with DLG4 and NOS1AP. Nitric oxide synthase GRCh38: Ensembl release 89: ENSG00000089250 – Ensembl...
neurotransmission. The synapsin I protein has been shown to interact with NOS1AP and SYN2. Mutations in the SYN1 gene may be associated with X-linked disorders...
LDL-receptor-related protein associated protein, LDLRAP1, MAGI1, MAPK8IP1, MAPK8IP2, NOS1AP, and SYNJ2BP. LRP2 has been shown to bind to the following ligands: Albumin...
cohorts (CARE and PROVE IT-TIMI 22). RASD1 has been shown to interact with NOS1AP. GRCh38: Ensembl release 89: ENSG00000108551 – Ensembl, May 2017 GRCm38:...