NEDD8 is a protein that in humans is encoded by the NEDD8 gene.[5][6] (in Saccharomyces cerevisiae this protein is known as Rub1) This ubiquitin-like (UBL) protein becomes covalently conjugated to a limited number of cellular proteins, in a process called NEDDylation similar to ubiquitination. Human NEDD8 shares 60% amino acid sequence identity to ubiquitin. The primary known substrates of NEDD8 modification are the cullin subunits of cullin-based E3 ubiquitin ligases, which are active only when NEDDylated. Their NEDDylation is critical for the recruitment of E2 to the ligase complex, thus facilitating ubiquitin conjugation. NEDD8 modification has therefore been implicated in cell cycle progression and cytoskeletal regulation.
^ abcGRCm38: Ensembl release 89: ENSMUSG00000010376 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Kamitani T, Kito K, Nguyen HP, Yeh ET (November 1997). "Characterization of NEDD8, a developmentally down-regulated ubiquitin-like protein". The Journal of Biological Chemistry. 272 (45): 28557–62. doi:10.1074/jbc.272.45.28557. PMID 9353319.
NEDD8 is a protein that in humans is encoded by the NEDD8 gene. (in Saccharomyces cerevisiae this protein is known as Rub1) This ubiquitin-like (UBL)...
(MLN4924) is a selective NEDD8 inhibitor. It is being investigated as a cancer treatment, e.g. for mantle cell lymphoma (MCL). NEDD8-activating enzyme (NAE)...
protein NEDD8 is conjugated to its target proteins. This process is analogous to ubiquitination, although it relies on its own E1 and E2 enzymes. No NEDD8-specific...
NEDD8-activating enzyme E1 regulatory subunit is a protein that in humans is encoded by the NAE1 gene. The protein encoded by this gene binds to the beta-amyloid...
in metazoans. The only identified Nedd8 substrates are cullins. Neddylation results in covalent conjugation of a Nedd8 moiety onto a conserved cullin lysine...
Sentrin-specific protease 8 is an enzyme that in humans is encoded by the SENP8 gene. NEDD8 (MIM 603171) is a ubiquitin-like protein that becomes conjugated to the...
is encoded by the UBA1 gene. UBA1 participates in ubiquitination and the NEDD8 pathway for protein folding and degradation, among many other biological...
"Covalent modification of all members of human cullin family proteins by NEDD8". Oncogene. 18 (48): 6829–34. doi:10.1038/sj.onc.1203093. PMID 10597293...
NEDD8 ultimate buster 1 is a protein that in humans is encoded by the NUB1 gene. NUB1 interacts with and negatively regulates NEDD8 (MIM 603171), a ubiquitin-like...
neuronal-precursor-cell-expressed developmentally downregulated protein-8 (NEDD8, also called Rub1 in S. cerevisiae), human leukocyte antigen F-associated...
NEDD8-conjugating enzyme Ubc12 is a protein that in humans is encoded by the UBE2M gene. The modification of proteins with ubiquitin is an important cellular...
acid excretion, the net amount of acid excreted in the urine per unit time NEDD8 activating enzyme North American English, a generalized variety of the English...
the complex is regulated by the attachment of the ubiquitin-like protein NEDD8 to a conserved Lys residue in the cullin-homology domain, the process called...
NEDD8-activating enzyme E1 catalytic subunit is a protein that in humans is encoded by the UBA3 gene. The modification of proteins with ubiquitin is an...
DC, Hunt HW, Hammel M, Schulman BA (Sep 2008). "Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation"...
proteins (UBLs), a class of proteins that are similar to ubiquitin, such as NEDD8. She has also extensively studied enzymes that for which ubiquitin and UBLs...
Cullin-associated NEDD8-dissociated protein 1 is a protein that in humans is encoded by the CAND1 gene. CAND1 has been shown to interact with: CUL1, CUL2...
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