positive regulation of transcription, DNA-templated
SCF complex assembly
cell differentiation
positive regulation of RNA polymerase II transcription preinitiation complex assembly
negative regulation of catalytic activity
protein ubiquitination
neutrophil degranulation
cellular iron ion homeostasis
post-translational protein modification
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
55832
71902
Ensembl
ENSG00000111530
ENSMUSG00000020114
UniProt
Q86VP6
Q6ZQ38
RefSeq (mRNA)
NM_001329674 NM_001329675 NM_001329676 NM_018448
NM_027994
RefSeq (protein)
NP_001316603 NP_001316604 NP_001316605 NP_060918
NP_082270
Location (UCSC)
Chr 12: 67.27 – 67.32 Mb
Chr 10: 119.04 – 119.08 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Cullin-associated NEDD8-dissociated protein 1 is a protein that in humans is encoded by the CAND1 gene.[5][6][7]
^ abcGRCh38: Ensembl release 89: ENSG00000111530 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000020114 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
^Yogosawa S, Makino Y, Yoshida T, Kishimoto T, Muramatsu M, Tamura T (Dec 1996). "Molecular cloning of a novel 120-kDa TBP-interacting protein". Biochemical and Biophysical Research Communications. 229 (2): 612–7. doi:10.1006/bbrc.1996.1852. PMID 8954946.
^"Entrez Gene: CAND1 cullin-associated and neddylation-dissociated 1".
NEDD8-dissociated protein 1 is a protein that in humans is encoded by the CAND1 gene. CAND1 has been shown to interact with: CUL1, CUL2, CUL3, CUL4A, CUL4B, DCUN1D1...
D) = Cand1 * min(dA1, dA2, ..., dAn) + Cand2 * max(dA1, dA2 ..., dAn) where Cor1, Cor2 are "softness" coefficients for the or operator, and Cand1, Cand2...
with RNF7. Part of a complex with TIP120A/CAND1 and RBX1. The unneddylated form interacts with TIP120A/CAND1 and the interaction negatively regulates the...
regulation of protein turn-over. RBX1 has been shown to interact with: CAND1, CUL1, CUL2, CUL4A, CUL5 CUL7, DCUN1D1, and P70-S6 Kinase 1. GRCh38: Ensembl...
incompatible with other proteins that it usually binds with. For example, CAND1 does not bind to neddylated proteins. In addition, neddylation can recruit...
degradation A subunit and holoenzyme of PP2A SCFubiquitin ligase regulator Cand1 Hsm3, a molecular chaperon involved in the assembly of 26Sproteasome Nucleo-cytoplasmic...
NEDD8 and cullin protein. Another protein that interacts with cullin is CAND1 which binds to deneddylated form of cullin protein and disrupts the interaction...
Garbutt KC, Liu J, Xiong Y, Zheng N (November 2004). "Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the...
by CRL4 complexes. Human CUL4A forms direct interactions with: DDB1 RBX1 CAND1 The COP9 signalosome Human CUL4A-DDB1-RBX1 complexes promote the ubiquitination...
humans is encoded by the CUL2 gene. CUL2 has been shown to interact with: CAND1, DCUN1D1, RBX1, SAP130, TCEB2 and Von Hippel-Lindau tumor suppressor. GRCh38:...
targeted by CRL4 complexes. Human CUL4B forms direct interactions with: RBX1 CAND1 DDB1 and the COP9 signalosome Human CUL4B-DDB1-RBX1 complexes promote the...
oncogenic driver in cancer cells. DCUN1D1 has been shown to interact with: CAND1, CUL1, CUL2, CUL3 and RBX1. GRCh38: Ensembl release 89: ENSG00000043093...
Matsumoto T, Xiong Y (2003). "NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases". Mol. Cell. 10 (6):...
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