APPBP1 information

NAE1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1R4M, 1R4N, 1TT5, 1YOV, 2NVU, 3DBH, 3DBL, 3DBR, 3GZN
Identifiers
Aliases	NAE1, A-116A10.1, APPBP1, ula-1, HPP1, NEDD8 activating enzyme E1 subunit 1
External IDs	OMIM: 603385; MGI: 2384561; HomoloGene: 68370; GeneCards: NAE1; OMA:NAE1 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	66,873,256 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	105,261,269 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; Achilles tendon; ; cerebellar hemisphere; ; ganglionic eminence; ; tibia; ; anterior pituitary; ; pons; ; parietal pleura; ; seminal vesicula; ; bronchial epithelial cell;
	Top expressed in
	primitive streak; ; spermatocyte; ; ciliary body; ; medial ganglionic eminence; ; iris; ; abdominal wall; ; maxillary prominence; ; facial motor nucleus; ; oocyte; ; cerebellar vermis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	NEDD8 activating enzyme activity; protein binding; ubiquitin-like modifier activating enzyme activity; ubiquitin protein ligase binding; protein heterodimerization activity;
Cellular component	cytoplasm; plasma membrane; membrane; cytosol; protein-containing complex;
Biological process	regulation of apoptotic process; neuron apoptotic process; cell cycle; protein neddylation; regulation of neuron apoptotic process; mitotic DNA replication checkpoint signaling; signal transduction; apoptotic process; post-translational protein modification; protein modification by small protein conjugation;
	Sources:Amigo / QuickGO
Orthologs
	8883
	234664
	ENSG00000159593
	ENSMUSG00000031878
	Q13564
	Q8VBW6
	NM_001018159; NM_001018160; NM_001286500; NM_003905
	NM_144931
	NP_001018169; NP_001018170; NP_001273429; NP_003896
	NP_659180
	Wikidata
View/Edit Human	View/Edit Mouse

NEDD8-activating enzyme E1 regulatory subunit is a protein that in humans is encoded by the NAE1 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000159593 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031878 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chow N, Korenberg JR, Chen XN, Neve RL (May 1996). "APP-BP1, a novel protein that binds to the carboxyl-terminal region of the amyloid precursor protein". The Journal of Biological Chemistry. 271 (19): 11339–46. doi:10.1074/jbc.271.19.11339. PMID 8626687.
^ Bohnsack RN, Haas AL (July 2003). "Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer". The Journal of Biological Chemistry. 278 (29): 26823–30. doi:10.1074/jbc.M303177200. PMID 12740388.
^ "Entrez Gene: APPBP1 amyloid beta precursor protein binding protein 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000159593 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031878 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Chow_N-5] Chow N, Korenberg JR, Chen XN, Neve RL (May 1996). "APP-BP1, a novel protein that binds to the carboxyl-terminal region of the amyloid precursor protein". The Journal of Biological Chemistry. 271 (19): 11339–46. doi:10.1074/jbc.271.19.11339. PMID 8626687.

[pmid12740388-6] Bohnsack RN, Haas AL (July 2003). "Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer". The Journal of Biological Chemistry. 278 (29): 26823–30. doi:10.1074/jbc.M303177200. PMID 12740388.

[entrez-7] "Entrez Gene: APPBP1 amyloid beta precursor protein binding protein 1".

APPBP1 information

and 6 Related for: APPBP1 information

APPBP1

NEDD8

UBE1C

Pevonedistat

UBE2M

TRIP12