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Myofibroblast
Histological section through testicular parenchyma of a boar. 1 Lumen of tubulus seminiferus contortus, 2 spermatids, 3 spermatocytes, 4 spermatogonia, 5 Sertoli cell, 6 Myofibroblasts, 7 Leydig cells, 8 capillaries
Details
Identifiers
Latin
myofibroblastus
MeSH
D058628
TH
H2.00.03.0.01013
Anatomical terms of microanatomy
[edit on Wikidata]
A myofibroblast is a cell phenotype that was first described as being in a state between a fibroblast and a smooth muscle cell.
A myofibroblast is a cell phenotype that was first described as being in a state between a fibroblast and a smooth muscle cell. Myofibroblasts are contractile...
contraction is the myofibroblast, which is a specialized contractile fibroblast. These cells express α-smooth muscle actin (α-SMA). The myofibroblasts are absent...
occurs without myofibroblast involvement. Later, fibroblasts, stimulated by growth factors, differentiate into myofibroblasts. Myofibroblasts, which are similar...
and compliance, through complex coiling. It has been suggested that myofibroblasts also reside in the lamina propria of several organs. These cells have...
contribute to basal lamina components in some situations (e.g. subepithelial myofibroblasts in intestine may secrete the α-2 chain-carrying component of the laminin...
factors to generate myofibroblasts. Dysregulated transforming growth factor β (TGF-β) signalling in fibroblasts and myofibroblasts has been observed in...
profile to resemble various other cell types, including macrophages, myofibroblasts, mesenchymal stem cells and osteochondrocytes. Importantly, genetic...
This is a list of cells in humans derived from the three embryonic germ layers – ectoderm, mesoderm, and endoderm. Trichocyte Keratinocyte Gonadotrope...
Saunders/Elsevier. ISBN 978-1-4377-0792-2. Shin D1, Minn KW. (2004). "The effect of myofibroblast on contracture of hypertrophic scar". Plast Reconstr Surg. 113 (2):...
infarction. Following injury, fibroblasts can become activated and turn into myofibroblasts – cells which exhibit behaviour somewhere between a fibroblast (generating...
becomes congested from engorged soft tissue. Elsewhere in the body, myofibroblasts of the nipple-areolar complex contract, causing erection of the nipples...
activates resident Hepatic Stellate Cells (HSCs) into the fibrogenic myofibroblasts that are largely responsible for liver fibrosis. However, whereas TNF...
insults that cause inflammation can result in the cells transforming into myofibroblasts, resulting in collagen production, fibrosis, and cirrhosis. The Space...
Zeinoun, T.; Nammour, S.; Dourov, N.; Aftimos, G.; Luomanen, M. (2001). "Myofibroblasts in healing laser excision wounds". Lasers in Surgery and Medicine. 28...
regeneration. Myofibroblasts are the fibroblast responsible for scar and in 2017 it was found that the regeneration of fat transformed myofibroblasts into adipocytes...
as alpha-smooth muscle actin or α-SMA) is often used as a marker of myofibroblast formation. Studies have shown that ACTA2 is associated with TGF-β pathway...
stellate cells, which increases fibrosis through the production of myofibroblasts, and obstructs hepatic blood flow. In addition, stellate cells secrete...
is characterized by faster resolution of inflammation and control of myofibroblast action compared to skin wounds in the red Duroc pig model". Journal...
new vessels at the zone of contact that is filled with pericytes and myofibroblasts. These cells begin laying collagen fibers into the core to provide an...
limits fibrosis during wound closure by inducing cell cycle arrest in myofibroblasts once they have fulfilled their function. When these cells have accomplished...
much stronger type I collagen. Some of the fibroblasts mature into myofibroblasts which contain the same type of actin found in smooth muscle, which enables...
with which hepatic stellate cells can be distinguished from portal myofibroblasts in the damaged human liver. In murine (rats, mice) liver, reelin expressed...
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