Global InformationNeohormone information
Neohormones are a group of recently evolved hormones primarily associated to the success of mammalian development.[1] These hormones are specific to mammals and are not found in other vertebrates[1]—this is because neohormones are evolved to enhance specific mammalian functions.[2] In males, neohormones play important roles in regulating testicular descent (the testes descend into the scrotum during foetal development) and preparing the sperm for internal fertilisation (the sperm fertilizes the egg within the female).[3] In females, neohormones are essential for regulating early pregnancy, mammary gland development lactation (secretion of milk from the mammary gland), and viviparity (allowing the fertilized egg to grow inside the female until they can exist independently).[1][2] Neohormones superimpose their actions on the hypothalamic-pituitary-gonadal axis (a hormone system which regulates key reproductive functions in animals) and are not associated with other core bodily functions.[2]
- ^ a b c Ivell R, Bathgate R (2006-05-01). "Neohormone systems as exciting targets for drug development". Trends in Endocrinology and Metabolism. 17 (4): 123. doi:10.1016/j.tem.2006.03.004. PMID 16580223. S2CID 46364208.
- ^ a b c Ivell R, Anand-Ivell R (August 2017). "Neohormones in milk" (PDF). Best Practice & Research. Clinical Endocrinology & Metabolism. SI: Hormones in milk - Part I. 31 (4): 419–425. doi:10.1016/j.beem.2017.10.005. PMID 29221570.
- ^ Anand-Ivell R, Dai Y, Ivell R (March 2013). "Neohormones as biomarkers of reproductive health". Fertility and Sterility. 99 (4): 1153–1160. doi:10.1016/j.fertnstert.2012.12.023. PMID 23337591.