Myelin basic protein (MBP) is a protein believed to be important in the process of myelination of nerves in the nervous system. The myelin sheath is a multi-layered membrane, unique to the nervous system, that functions as an insulator to greatly increase the velocity of axonal impulse conduction.[5] MBP maintains the correct structure of myelin, interacting with the lipids in the myelin membrane.[6][7]
MBP was initially sequenced in 1971 after isolation from bovine myelin membranes.[8] MBP knockout mice called shiverer mice were subsequently developed and characterized in the early 1980s. Shiverer mice exhibit decreased amounts of CNS myelination and a progressive disorder characterized by tremors, seizures, and early death. The human gene for MBP is on chromosome 18;[9] the protein localizes to the CNS and to various cells of the hematopoietic lineage.
The pool of MBP in the central nervous system is very diverse, with several splice variants being expressed and a large number of post-translational modifications on the protein, which include phosphorylation, methylation, deamidation, and citrullination. These forms differ by the presence or the absence of short (10 to 20 residues) peptides in various internal locations in the sequence. In general, the major form of MBP is a protein of about 18.5 Kd (170 residues).
In melanocytic cell types, MBP gene expression may be regulated by MITF.[10]
^ abcGRCh38: Ensembl release 89: ENSG00000197971 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000041607 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Sakamoto Y, Kitamura K, Yoshimura K, Nishijima T, Uyemura K (March 1987). "Complete amino acid sequence of PO protein in bovine peripheral nerve myelin". The Journal of Biological Chemistry. 262 (9): 4208–4214. doi:10.1016/S0021-9258(18)61334-1. PMID 2435734.
^Deber CM, Reynolds SJ (April 1991). "Central nervous system myelin: structure, function, and pathology". Clinical Biochemistry. 24 (2): 113–134. doi:10.1016/0009-9120(91)90421-a. PMC 7130177. PMID 1710177.
^Inouye H, Kirschner DA (January 1991). "Folding and function of the myelin proteins from primary sequence data". Journal of Neuroscience Research. 28 (1): 1–17. doi:10.1002/jnr.490280102. PMID 1710279. S2CID 8598890.
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and 26 Related for: Myelin basic protein information
Myelinbasicprotein (MBP) is a protein believed to be important in the process of myelination of nerves in the nervous system. The myelin sheath is a...
divided into 6 exons. In total, myelinprotein zero is 219 amino acids long and has many basic amino acid residues. Myelinprotein zero consists of an extracellular...
biochemist and neuroscientist known for purifying and characterizing myelinbasicprotein (MBP), investigating its potential role in the neurodegenerative...
includes myelinbasicprotein (MBP), which is abundant in the CNS where it plays a critical, non-redundant role in formation of compact myelin; myelin oligodendrocyte...
acids found in myelinbasicprotein, namely glutamic acid, lysine, alanine, and tyrosine. Myelinbasicprotein is the antigen in the myelin sheaths of the...
Proteolipid protein 1 (PLP1) is a form of myelin proteolipid protein (PLP). Mutations in PLP1 are associated with Pelizaeus–Merzbacher disease. It is a...
in which T cells are essentially confusing an HHV-6 viral protein with myelinbasicprotein, first appeared around this time. Early on in the development...
Protein methylase I may refer to: Histone-arginine N-methyltransferase (Myelinbasicprotein)-arginine N-methyltransferase This set index page lists enzyme...
Milk basicprotein, a milk protein fraction Myc-binding protein-1, a protein encoded by the alpha-enolase glycolytic enzyme Myelinbasicprotein, a protein...
axon being wrapped in approximately 1 μm of myelin sheath. Furthermore, an oligodendrocyte can provide myelin segments for multiple adjacent axons. Oligodendrocytes...
PMID 2313748. Wang Q, Wang Z, Zhu P, Jiang J (2004). "Alterations of the MyelinBasicProtein and Ultrastructure in the Limbic System and the Early Stage of Trauma-Related...
antibodies sent to myelinbasicprotein (MBP), which is involved in the myelination of neurons, and glial fibrillary acidic protein (GFAP), which is essential...
calcium ions. Proteins that normally contain citrulline residues include myelinbasicprotein (MBP), filaggrin, and several histone proteins, whereas other...
to the release of antigens such as myelin oligodendrocyte glycoprotein, myelinbasicprotein, and proteolipid protein, causing an autoimmune response. This...
suggesting a role in apoptosis. One of PAD2's target substrates is myelinbasicprotein (MBP). In the normal retina, deimination is found in nearly all the...
S2CID 206490102. Georgios Tsekenis (2008). "Label-free immunosensor assay for myelinbasicprotein based upon an ac impedance protocol". Analytical Chemistry. 80 (6):...
axons in organized, multilamellar myelin sheaths that contain myelinbasicprotein (MBP) and myelin proteolipid protein (PLP). Myelinogenesis thus encompasses...
a surface-active complex of phospholipids and proteins formed by type II alveolar cells. The proteins and lipids that make up the surfactant have both...
expressed in interneurons. Proteins expressed in glial cells include astrocyte markers GFAP and S100B whereas myelinbasicprotein and the transcription factor...
(Fox-3, Rbfox3, or Hexaribonucleotide Binding Protein-3), a protein which is a homologue to the protein product of a sex-determining gene in Caenorhabditis...
composition of myelin is different in the two types. In the CNS the major myelinprotein is proteolipid protein, and in the PNS it is myelinbasicprotein. Nodes...
an increase in the expression of transcripts encoding myelinbasicprotein, endoplasmic proteins, cytochrome oxidase, and two cell adhesion molecules:...
Ferra F, Hudson L, Lazzarini RA (1986). "Recombination within the myelinbasicprotein gene created the dysmyelinating shiverer mouse mutation". Proc Natl...
c-Jun N-terminal Kinase (JNK), p38 mitogen-activated protein kinase (MAPK), and p36 myelinbasicprotein (MBP) kinase. Cytotrienin A is an ansamycin with...
generation could be accelerated further. Using a novel protocol, myelinbasicprotein (MBP), a marker for oligodendrocyte differentiation and myelination...
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