"Synthia" redirects here. For album by The Jezabels, see Synthia (album).
This article is missing information about division morphology issues in JCVI-syn3.0 and the fix in JCVI-syn3A. Please expand the article to include this information. Further details may exist on the talk page.(March 2021)
Mycoplasma laboratorium
Scientific classification
Domain:
Bacteria
Phylum:
Mycoplasmatota
Class:
Mollicutes
Order:
Mycoplasmatales
Family:
Mycoplasmataceae
Genus:
Mycoplasma
Species:
M. mycoides
Subspecies:
M. m. JCVI-syn1.0
Trinomial name
Mycoplasma mycoides JCVI-syn1.0
Gibson et al., 2010[a 1]
Synonyms[a 2]
Mycoplasma laboratorium Reich, 2000
Mycoplasma laboratorium or Synthia[b 1] refers to a synthetic strain of bacterium. The project to build the new bacterium has evolved since its inception. Initially the goal was to identify a minimal set of genes that are required to sustain life from the genome of Mycoplasma genitalium, and rebuild these genes synthetically to create a "new" organism. Mycoplasma genitalium was originally chosen as the basis for this project because at the time it had the smallest number of genes of all organisms analyzed. Later, the focus switched to Mycoplasma mycoides and took a more trial-and-error approach.[b 2]
To identify the minimal genes required for life, each of the 482 genes of M. genitalium was individually deleted and the viability of the resulting mutants was tested. This resulted in the identification of a minimal set of 382 genes that theoretically should represent a minimal genome.[a 3] In 2008 the full set of M. genitalium genes was constructed in the laboratory with watermarks added to identify the genes as synthetic.[b 3][a 4] However M. genitalium grows extremely slowly and M. mycoides was chosen as the new focus to accelerate experiments aimed at determining the set of genes actually needed for growth.[b 4]
In 2010, the complete genome of M. mycoides was successfully synthesized from a computer record and transplanted into an existing cell of Mycoplasma capricolum that had had its DNA removed.[b 5] It is estimated that the synthetic genome used for this project cost US$40 million and 200 man-years to produce.[b 4] The new bacterium was able to grow and was named JCVI-syn1.0, or Synthia. After additional experimentation to identify a smaller set of genes that could produce a functional organism, JCVI-syn3.0 was produced, containing 473 genes.[b 2] 149 of these genes are of unknown function.[b 2] Since the genome of JCVI-syn3.0 is novel, it is considered the first truly synthetic organism.
Cite error: There are <ref group=a> tags on this page, but the references will not show without a {{reflist|group=a}} template (see the help page). Cite error: There are <ref group=b> tags on this page, but the references will not show without a {{reflist|group=b}} template (see the help page).
and 21 Related for: Mycoplasma laboratorium information
Mycoplasmalaboratorium or Synthia refers to a synthetic strain of bacterium. The project to build the new bacterium has evolved since its inception....
DNA which can self-replicate has been referred to as Mycoplasmalaboratorium. Several Mycoplasma species can cause disease, including M. pneumoniae, which...
with its old DNA removed; the resulting bacterium will be called Mycoplasmalaboratorium. The next day the Canadian bioethics group, ETC Group issued a...
institute later started a project to create a synthetic organism named Mycoplasmalaboratorium, using the minimal set genes identified from M. genitalium. Reconstruction...
approaches to construct synthetic chromosomes or minimal organisms like Mycoplasmalaboratorium. Biomolecular design refers to the general idea of de novo design...
kb Mycoplasma genitalium genome in 2008, the first synthetic organism ever created. Similar steps were taken in synthesizing the larger Mycoplasma mycoides...
team succeeded in creating a replicating strain (named Mycoplasmalaboratorium) of Mycoplasma mycoides using synthetically created DNA deemed to be the...
entirely synthesized DNA to create a self-replicating microbe, dubbed Mycoplasmalaboratorium. Oligonucleotide synthesis is the chemical synthesis of sequences...
life focus on engineering live minimal cells from living bacteria Mycoplasmalaboratorium and in building non-living biochemical cell-like systems from scratch...
a partially synthetic species of bacterium, Mycoplasmalaboratorium, derived from the genome of Mycoplasma genitalium. Population genomics has developed...
it into an empty bacterial cell. The resulting bacterium, named Mycoplasmalaboratorium, could replicate and produce proteins. Four years later this was...
The first quantum machine 2010: The first synthetic organism, Mycoplasmalaboratorium is created by the J. Craig Venter Institute. 2011: Twitch, launches...
patent the first partially synthetic species possibly to be named Mycoplasmalaboratorium. There is speculation that this line of research could lead to...
rewritten genome. In 2010, at the cost of $40 million an organism, Mycoplasmalaboratorium, was constructed that was controlled by a synthetic, but not recoded...
genes. This builds upon their earlier research that synthesised Mycoplasmalaboratorium in 2010. 29 March – Case Western Reserve University announces an...
Global Information
