Monoamine oxidase B, also known as MAO-B, is an enzyme that in humans is encoded by the MAOB gene.
The protein encoded by this gene belongs to the flavin monoamine oxidase family. It is an enzyme located in the outer mitochondrial membrane. It catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the catabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. This protein preferentially degrades benzylamine and phenethylamine.[5] Similar to monoamine oxidase A (MAO-A), MAO-B is also involved in the catabolism of dopamine.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000069535 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000040147 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: MAOB monoamine oxidase B".
^Tan YY, Jenner P, Chen SD (2022). "Monoamine Oxidase-B Inhibitors for the Treatment of Parkinson's Disease: Past, Present, and Future". Journal of Parkinson's Disease. 12 (2): 477–493. doi:10.3233/JPD-212976. PMC 8925102. PMID 34957948. There are two MAO isoenzymes: MAO-A and MAO-B. MAO-A is mainly distributed in the gastrointestinal tract, platelets, and heart, and can promote the metabolism of tyramine-containing substances in food so avoiding hypertensive crises caused by the accumulation of tyramine ("cheese reaction"). MAO-A also exists in catecholaminergic neurons, such as dopaminergic neurons in SN, norepinephrine neurons in locus coeruleus, etc. [18]. MAO-B is mainly distributed in platelets and glial cells, and total MAO activity within the brain is composed of approximately 20% MAO-A and 80% MAO-B [19–22]. Both MAO-A and MAO-B regulate the amine neurotransmitters, including dopamine. MAO-A metabolizes dopamine in presynaptic neurons, while MAO-B metabolizes dopamine released to synaptic cleft and taken up by glial cells. The number of glial cells was shown to increase with age, and in neurodegenerative diseases, as expected, the activity of MAO-B also increased [23–25]. MAO-B inhibitors inhibit MAO-B activity in the brain, block dopamine catabolism, enhance dopamine signaling, and selectively enhance dopamine levels at synaptic cleft [21].
and 26 Related for: Monoamine oxidase B information
MonoamineoxidaseB, also known as MAO-B, is an enzyme that in humans is encoded by the MAOB gene. The protein encoded by this gene belongs to the flavin...
Monoamineoxidase inhibitors (MAOIs) are a class of drugs that inhibit the activity of one or both monoamineoxidase enzymes: monoamineoxidase A (MAO-A)...
Monoamineoxidases (MAO) (EC 1.4.3.4) are a family of enzymes that catalyze the oxidation of monoamines, employing oxygen to clip off their amine group...
Monoamineoxidase A, also known as MAO-A, is an enzyme (E.C. 1.4.3.4) that in humans is encoded by the MAOA gene. This gene is one of two neighboring...
a significant amount is metabolized in the small intestine by monoamineoxidaseB (MAO-B) and then aldehyde dehydrogenase (ALDH), which converts it to...
Harmala alkaloids are several alkaloids that act as monoamineoxidase inhibitors (MAOIs). These alkaloids are found in the seeds of Peganum harmala (also...
of monoamineoxidaseB (MAO-B), increasing levels of dopamine in the brain. In larger doses (more than 20 mg/day), it loses its specificity for MAO-B and...
noradrenergic and specific serotonergic antidepressants (NaSSAs). Monoamineoxidase inhibitors include Isocarboxazid (Marplan) Phenelzine (Nardil) Tranylcypromine...
diarrhea Brunner syndrome is caused by a monoamineoxidase A (MAOA) deficiency, which leads to an excess of monoamines in the brain, such as serotonin, dopamine...
Rasagiline (Azilect, Azipron) is an irreversible inhibitor of monoamineoxidase-B used as a monotherapy to treat symptoms in early Parkinson's disease...
SNRIs, TCAs, and MAOIs, which act mainly by increasing the levels of the monoamine neurotransmitters serotonin and/or norepinephrine. Among TCAs, trimipramine...
episodes; it has multiple modes of action, including the inhibition of monoamineoxidaseB. It was approved in the European Union in February 2015, in the United...
of the antiparkinson's drug selegiline. Selegiline, a selective monoamineoxidaseB (MAOB) inhibitor at low doses, is also metabolized into levomethamphetamine...
of monoamineoxidase inhibitors (MAOIs). Tyramine occurs widely in plants and animals, and is metabolized by various enzymes, including monoamine oxidases...
F, Campeas R, Welkowitz L, Hatterer J, Fallon B (1990). "Reversible and irreversible monoamineoxidase inhibitors in other psychiatric disorders". Acta...
Clobemix, Depnil and Manerix among others, is a reversible inhibitor of monoamineoxidase A (RIMA) drug primarily used to treat depression and social anxiety...
is a monoamineoxidase inhibitor (MAOI). More specifically, tranylcypromine acts as nonselective and irreversible inhibitor of the enzyme monoamine oxidase...
alcohol withdrawal. It should be avoided in individuals who are taking monoamineoxidase inhibitors (MAOIs). The label recommends that caution should be exercised...
Pirlindole (Lifril, Pyrazidol) is mainly a reversible inhibitor of monoamineoxidase A (RIMA) and secondly a SNRI which was developed and is used in Russia...
Metralindole (Inkazan) is a reversible inhibitor of monoamineoxidase A (RIMA) which was investigated in Russia as a potential antidepressant. It is structurally...
Isocarboxazid (Marplan, Marplon, Enerzer) is a non-selective, irreversible monoamineoxidase inhibitor (MAOI) of the hydrazine class used as an antidepressant...
syndrome. Taking monoamineoxidase inhibitors (MAOIs) in combination with SSRIs can be fatal, since MAOIs disrupt monoamineoxidase, an enzyme which is...
(trade names Sursum, Sinderesin) is an irreversible and selective monoamineoxidase inhibitor (MAOI) of the hydrazine chemical class that was used as...
dioxide and hypromellose. It should not be used in conjunction with a monoamineoxidase inhibitor (MAOI), as it can cause potentially fatal serotonin syndrome...