Mevalonate pathway diagram showing the conversion of acetyl-CoA into isopentenyl pyrophosphate, the essential building block of all isoprenoids. The eukaryotic variant is shown in black. Archaeal variants are shown in red and blue.
The mevalonate pathway, also known as the isoprenoid pathway or HMG-CoA reductase pathway is an essential metabolic pathway present in eukaryotes, archaea, and some bacteria.[1] The pathway produces two five-carbon building blocks called isopentenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP), which are used to make isoprenoids, a diverse class of over 30,000 biomolecules such as cholesterol, vitamin K, coenzyme Q10, and all steroid hormones.[2]
The mevalonate pathway begins with acetyl-CoA and ends with the production of IPP and DMAPP.[3] It is best known as the target of statins, a class of cholesterol lowering drugs. Statins inhibit HMG-CoA reductase within the mevalonate pathway.
^Cite error: The named reference GENERAL was invoked but never defined (see the help page).
^Cite error: The named reference ISOPRENOIDS was invoked but never defined (see the help page).
^Cite error: The named reference REVIEW was invoked but never defined (see the help page).
and 21 Related for: Mevalonate pathway information
The mevalonatepathway, also known as the isoprenoid pathway or HMG-CoA reductase pathway is an essential metabolic pathway present in eukaryotes, archaea...
by two distinct metabolic pathways: the mevalonate (MVA) pathway and the non-mevalonate (MEP) pathway. These two pathways are mutually exclusive in most...
final step in the mevalonatepathway. The mevalonatepathway is responsible for the biosynthesis of isoprenoids from acetate. This pathway plays a key role...
non-mevalonatepathway (MEP pathway) uses pyruvate and glyceraldehyde 3-phosphate as substrates to produce IPP and DMAPP. During diseases pathways otherwise...
enzyme in the Mevalonatepathway, it catalyzes the phosphorylation of Mevalonic acid to produce Mevalonate-5-phosphate. A reduction in mevalonate kinase activity...
Mevalonate kinase deficiency (MKD) is an autosomal recessive metabolic disorder that disrupts the biosynthesis of cholesterol and isoprenoids. It is a...
mutation. Mevalonic acid is a precursor in the biosynthetic pathway known as the mevalonatepathway that produces terpenes and steroids. Mevalonic acid is...
is an isoprenoid precursor. It is a product of both the mevalonatepathway and the MEP pathway of isoprenoid precursor biosynthesis. It is an isomer of...
and archaea, the mevalonatepathway produces these compounds from acetyl-CoA, while in plants and bacteria the non-mevalonatepathway uses pyruvate and...
the classical, HMG-CoA reductase pathway (commonly called the mevalonatepathway) and in the non-mevalonate MEP pathway of isoprenoid precursor biosynthesis...
involve the mevalonatepathway (MVA) and the cyclization of farnesyl diphosphate (FDP). It is not clear whether the non-mevalonatepathway can also contribute...
competitively inhibiting HMG-CoA reductase, the rate-limiting enzyme of the mevalonatepathway. Because statins are similar in structure to HMG-CoA on a molecular...
4-phosphate pathway (MEP pathway, also called the non-mevalonatepathway) in the chloroplasts of plants. One of the two end-products of MEP pathway, dimethylallyl...
cholesterol via the mevalonatepathway. Leucine is an essential amino acid in the diet of animals because they lack the complete enzyme pathway to synthesize...
the mevalonatepathway. Thiolases are ubiquitous enzymes that have key roles in many vital biochemical pathways, including the beta oxidation pathway of...
limonene are naturally occurring monocyclic terpenes derived from the mevalonatepathway in plants. Perillyl alcohol can be found in the essential oils of...
occurs by a complex 37-step process. This begins with the mevalonate or HMG-CoA reductase pathway, the target of statin drugs, which encompasses the first...
; Newman, Jack D.; Keasling, Jay D. (2003-07-01). "Engineering a mevalonatepathway in Escherichia coli for production of terpenoids". Nature Biotechnology...
secoiridoid monoterpene synthesized from geranyl pyrophosphate in the mevalonatepathway. Secologanin then proceeds with dopamine or tryptamine to form ipecac...
and archaea, the mevalonatepathway produces these compounds from acetyl-CoA, while in plants and bacteria the non-mevalonatepathway uses pyruvate and...
Global Information