Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Chemical compound
Mevalonic acid (MVA) is a key organic compound in biochemistry; the name is a contraction of dihydroxymethylvalerolactone. The carboxylate anion of mevalonic acid, which is the predominant form in biological environments, is known as mevalonate and is of major pharmaceutical importance. Drugs like statins (which lower levels of cholesterol) stop the production of mevalonate by inhibiting HMG-CoA reductase.[1]
^Endo, A. (1992). "The discovery and development of HMG-CoA reductase inhibitors". Journal of Lipid Research. 33 (11): 1569–1582. PMID 1464741.
Mevalonicacid (MVA) is a key organic compound in biochemistry; the name is a contraction of dihydroxymethylvalerolactone. The carboxylate anion of mevalonic...
the structurally related sesquiterpenes, which are formed from the mevalonicacid-derived precursor farnesyl diphosphate (FDP), the C15 backbone of ABA...
reduced or deficient activity of this enzyme. Because of this deficiency, mevalonicacid can build up in the body, with high levels found in the urine. The severity...
DMAPP and IPP. In the mevalonate pathway DMAPP is synthesised from mevalonicacid. In contrast, DMAPP is synthesised from HMBPP in the MEP pathway. At...
form 4-L-dimethylallyltryptophan (4-L-DMAT). The DMAPP is derived from mevalonicacid. A three strep mechanism is proposed to form 4-L-DMAT: the formation...
researching the biosynthesis of cholesterol in the early 1950s. In 1956, mevalonicacid was isolated from a yeast extract by Karl Folkers, Carl Hoffman, and...
form 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) which then is reduced to mevalonicacid (MVA). A series of ATP-dependent transformations lead to a key isoprene...
in plastids. Carotenoids formed in fungi are presumably formed from mevalonicacid precursors. Carotenoids are formed by a head-to-head condensation of...
pyrophosphate, which is formed from acetyl-CoA via the intermediacy of mevalonicacid in the HMG-CoA reductase pathway. An alternative, unrelated biosynthesis...
free in Crotalaria dura and C. globifera and is bound in dicrotaline (pyrrolizidine alkaloid). Crotalaria List of Crotalaria species Mevalonicacid v t e...
(E,E)-farnesyl diphosphate. Bactoprenol is a lipid synthesized from mevalonicacid and is the most abundant lipid found in certain species of lactobacilli...
cyanobacteria is similar, as are the enzymes involved. Synthesis begins with mevalonicacid, which is converted into dimethylallyl pyrophosphate. This is then condensed...
method of abortion that consists of removing the embryo by suction Mevalonicacid, an important compound in molecular biology Mimotope Variation Analysis...
The complete biosynthesis of viridin is not known. Through [2-14C]mevalonicacid labeling studies, it has been shown that viridin is biosynthesized from...
phytoecdysteroids. Plants, but not animals, synthesize phytoecdysteroids from mevalonicacid in the mevalonate pathway of the plant cell using acetyl-CoA as a precursor...
enzyme in the Mevalonate pathway, it catalyzes the phosphorylation of Mevalonicacid to produce Mevalonate-5-phosphate. A reduction in mevalonate kinase...
showed that acetyl Coenzyme A is turned into mevalonicacid. Both Bloch and Lynen then showed that mevalonicacid is converted into chemically active isoprene...
known to use two different pathways for IPP production: the cytosolic mevalonicacid pathway (MVA) and the plastidic methylerythritol 4-phosphate (MEP)....
biosynthesis of terpenoids occurs via the methylerythritol phosphate (MEP) and mevalonicacid(MVA) pathways both of which include isopentenyl diphosphate (IPP) and...
4,5-Cyclohexanetetrol 2,3-Dihydroxy-3-methylpentanoic acid Kethoxal Mevalonicacid Pantoic acid This set index page lists chemical structure articles...
that contain only fatty acid derivatives and PP + MAP type secretions that contain fatty acid derivatives and mevalonicacid derivatives in the form of...
of the microsomal enzyme that catalyzes the conversion of HMG CoA to mevalonicacid, and that has been considered to be a prime target for pharmacologic...
group also includes some related compounds with neutral and even weakly acidic properties. Some synthetic compounds of similar structure may also be termed...
diphosphate and dimethylallyl diphosphate, which are produced mainly via the mevalonicacid (MVA) pathway. The simple isoprenoids (linear alcohols, diphosphates...
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