Periodic paralysis is a group of rare genetic diseases that lead to weakness or paralysis[1] from common triggers such as cold, heat, high carbohydrate meals, not eating, stress or excitement and physical activity of any kind. The underlying mechanism of these diseases are malfunctions in the ion channels in skeletal muscle cell membranes that allow electrically charged ions to leak in or out of the muscle cell, causing the cell to depolarize and become unable to move.[2]
The symptoms of periodic paralysis can also be caused by hyperthyroidism, and are then labeled thyrotoxic periodic paralysis; however, if this is the underlying condition there are likely to be other characteristic manifestations, enabling a correct diagnosis.
Periodicparalysis is a group of rare genetic diseases that lead to weakness or paralysis from common triggers such as cold, heat, high carbohydrate meals...
Hypokalemic periodicparalysis (hypoKPP), also known as familial hypokalemic periodicparalysis (FHPP), is a rare, autosomal dominant channelopathy characterized...
Thyrotoxic periodicparalysis (TPP) is a rare condition featuring attacks of muscle weakness in the presence of hyperthyroidism (overactivity of the thyroid...
Hyperkalemic periodicparalysis (HYPP, HyperKPP) is an inherited autosomal dominant disorder that affects sodium channels in muscle cells and the ability...
include narcolepsy, atonic seizure, and hypokalemic periodicparalysis. Treatment options for sleep paralysis have been poorly studied. It is recommended that...
nature; however, some forms of periodicparalysis, including sleep paralysis, are caused by other factors. Paralysis can occur in newborns due to a congenital...
release of epinephrine is a well-demonstrated cause of paralysis from hypokalemic periodicparalysis. Misdiagnosis does sometimes occur. In a highly influential...
Although more typical of the periodic paralytic disorders, patients with PC may also have potassium-provoked paralysis. PC typically presents within...
is used for treating horses with the genetic disease hyperkalemic periodicparalysis (HYPP), and prevents affected animals from having seizures. Acet is...
orphan drug for the treatment of primary hypokalemic and hyperkalemic periodicparalysis. In 2001, diclofenamide had a U.S. list price of $50 for a bottle...
of ion channels, in particular to the muscle disorder hypokalemic periodicparalysis. Some females with premenstrual syndrome may have the same autosomal...
skeletal system, but the massive build is also linked to hyperkalemic periodicparalysis (HYPP) in descendants of the stallion Impressive (see Genetic diseases...
deafness in the Jervell and Lange-Nielsen form of the condition, and periodicparalysis in the Andersen–Tawil (LQT7) form. While those with long QT syndrome...
activated, extracellularly decrease potassium concentration. Hyperkalemic periodicparalysis is an autosomal dominant clinical condition where there is a mutation...
of muscular ion channels and transporters that cause hypokalemic periodicparalysis can precipitate occasional attacks of severe hypokalemia and muscle...
was also the first to recognise the association between familial periodicparalysis and low blood potassium levels. Mary Walker was born at Croft-an-Righ...
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