Metabotropic glutamate receptor 4 is a protein that in humans is encoded by the GRM4 gene.[5][6][7]
Together with GRM6, GRM7 and GRM8 it belongs to group III of the metabotropic glutamate receptor family. Group III receptors are linked to the inhibition of the cyclic AMP cascade.[7]
Activation of GRM4 has potential therapeutic benefits in the treatment of parkinson's disease. Splice variant "taste-GRM4" is involved in the perception of umami taste.[8]
^ abcGRCh38: Ensembl release 89: ENSG00000124493 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000063239 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Makoff A, Lelchuk R, Oxer M, Harrington K, Emson P (Apr 1996). "Molecular characterization and localization of human metabotropic glutamate receptor type 4". Brain Research. Molecular Brain Research. 37 (1–2): 239–48. doi:10.1016/0169-328X(95)00321-I. PMID 8738157.
^Wu S, Wright RA, Rockey PK, Burgett SG, Arnold JS, Rosteck PR, Johnson BG, Schoepp DD, Belagaje RM (Jan 1998). "Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells". Brain Research. Molecular Brain Research. 53 (1–2): 88–97. doi:10.1016/S0169-328X(97)00277-5. PMID 9473604.
Metabotropicglutamatereceptor4 is a protein that in humans is encoded by the GRM4 gene. Together with GRM6, GRM7 and GRM8 it belongs to group III of...
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message (i.e. metabotropicreceptors do not have channels). There are several kinds of metabotropicreceptors, including G protein-coupled receptors. Ionotropic...
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methylene blue by milk". The Journal of General Physiology. 1 (4): 415–419. doi:10.1085/jgp.1.4.415. PMC 2140316. PMID 19871757. Jakubowski H (2016). "Chapter...
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amino acid receptor antagonist, or glutamatereceptor antagonist, is a chemical substance which antagonizes one or more of the glutamatereceptors. Examples...
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