Kainate receptors, or kainic acid receptors (KARs), are ionotropic receptors that respond to the neurotransmitter glutamate. They were first identified as a distinct receptor type through their selective activation by the agonist kainate, a drug first isolated from the algae Digenea simplex. They have been traditionally classified as a non-NMDA-type receptor, along with the AMPA receptor. KARs are less understood than AMPA and NMDA receptors, the other ionotropic glutamate receptors. Postsynaptic kainate receptors are involved in excitatory neurotransmission. Presynaptic kainate receptors have been implicated in inhibitory neurotransmission by modulating release of the inhibitory neurotransmitter GABA through a presynaptic mechanism.
Kainatereceptors, or kainic acid receptors (KARs), are ionotropic receptors that respond to the neurotransmitter glutamate. They were first identified...
receptor, along with the kainatereceptor. Its name is derived from its ability to be activated by the artificial glutamate analog AMPA. The receptor...
glutamate receptors: NMDA receptors, AMPA receptors, kainatereceptors, and the metabotropic glutamate receptors. Kainic acid is an agonist for kainate receptors...
is one of three types of ionotropic glutamate receptors, the other two being AMPA and kainatereceptors. Depending on its subunit composition, its ligands...
than AMP receptors. In general, the function of kainatereceptors is much less characterized than AMPA receptors. Interestingly, kainatereceptors are expressed...
Glutamate receptor, ionotropic, kainate 1, also known as GRIK1, is a protein that in humans is encoded by the GRIK1 gene. This gene encodes one of the...
Glutamate ionotropic receptorkainate type subunit 2, also known as ionotropic glutamate receptor 6 or GluR6, is a protein that in humans is encoded by...
are activated by the neurotransmitter kainate and are permeable to both sodium and potassium ions. Kainatereceptors are expressed in a variety of brain...
this receptor. In addition to this GABAergic effect, barbiturates also block AMPA and kainatereceptors, subtypes of ionotropic glutamate receptor. Glutamate...
GRIK4 (glutamate receptor, ionotropic, kainate 4) is a kainatereceptor subtype belonging to the family of ligand-gated ion channels which is encoded by...
and sequence similarity: AMPA receptors, kainatereceptors, NMDA receptors and delta receptors (see below). AMPA receptors are the main charge carriers...
the micromolar range, including the AMPA and kainatereceptors and, to a lesser extent, the NMDA receptor. It acts as an antagonist of the former two sites...
the AMPA and kainate subtypes of the ionotropic glutamate receptor family, with selectivity for the GluR5 subtype of the kainatereceptor. It has neuroprotective...
acetylcholine receptor (nAChR), the 5-HT3 receptor, the glycine receptor and others. Surprisingly, while GABAA receptor currents are increased by barbiturates...
5-HT3 receptors, and as a negative allosteric modulator of the AMPA, kainate, and NMDA receptors, as well as of nicotinic acetylcholine receptors. Clinically...
cyanquixaline (6-cyano-7-nitroquinoxaline-2,3-dione) is a competitive AMPA/kainatereceptor antagonist. Its chemical formula is C9H4N4O4. CNQX is often used in...
negative allosteric modulator of the AMPA, kainate, and glycine receptors, and may interact with the nACh receptors as well. In addition to its effects on...
receptors can include NMDA, AMPA, and kainatereceptors. These receptors are named after agonists that facilitate glutamate activity. NMDA receptors are...
metabotropic glutamate receptors. It is inactive at group III mGluRs. Ibotenic acid also acts as a weak agonist of the AMPA and kainatereceptors. In addition,...
antagonist of the AMPA receptor. NBQX blocks AMPA receptors in micromolar concentrations (~10–20 μM) and also blocks kainatereceptors. In experiments, it...
NMDA receptor antagonists are a class of drugs that work to antagonize, or inhibit the action of, the N-Methyl-D-aspartate receptor (NMDAR). They are commonly...
quinoxalinedione series which acts as a competitive antagonist of the AMPA and kainatereceptors and, as of 2015, is being investigated in clinical trials by Novartis...
useful to isolate the action of other glutamate receptors in the brain, i.e., AMPA and kainatereceptors. AP5 can block the conversion of a silent synapse...
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