Folate targeting is a method utilized in biotechnology for drug delivery purposes. This Trojan Horse process, which was created by Drs. Christopher P. Leamon and Philip S. Low, involves the attachment of the vitamin, folate (folic acid), to a molecule/drug to form a "folate conjugate".[1] Based on the natural high affinity of folate for the folate receptor protein (FR), which is commonly expressed on the surface of many human cancers, folate-drug conjugates also bind tightly to the FR and trigger cellular uptake via endocytosis. Molecules as diverse as small radiodiagnostic imaging agents to large DNA plasmid formulations have successfully been delivered inside FR-positive cells and tissues.[2][3]
^Leamon CP, Low PS (July 1991). "Delivery of macromolecules into living cells: a method that exploits folate receptor endocytosis". Proc. Natl. Acad. Sci. U.S.A. 88 (13): 5572–6. doi:10.1073/pnas.88.13.5572. PMC 51919. PMID 2062838.
^Leamon CP (December 2008). "Folate-targeted drug strategies for the treatment of cancer". Curr Opin Investig Drugs. 9 (12): 1277–86. PMID 19037834.
^Low PS, Kularatne SA (June 2009). "Folate-targeted therapeutic and imaging agents for cancer". Curr Opin Chem Biol. 13 (3): 256–62. doi:10.1016/j.cbpa.2009.03.022. PMID 19419901.
Folatetargeting is a method utilized in biotechnology for drug delivery purposes. This Trojan Horse process, which was created by Drs. Christopher P....
Folate, also known as vitamin B9 and folacin, is one of the B vitamins. Manufactured folic acid, which is converted into folate by the body, is used as...
is a small molecule drug conjugate consisting of a small molecule targeting the folate receptor, which is expressed on many cancers, such as ovarian cancer...
is a small molecule drug conjugate consisting of a small molecule targeting the folate receptor, which is overexpressed on certain cancers, such as ovarian...
Folate receptor 1 (Folate receptor alpha, FOLR1) is a protein that in humans is encoded by the FOLR1 gene. The protein encoded by this gene is a member...
blood donation. Causes of decreased production include iron deficiency, folate deficiency, vitamin B12 deficiency, thalassemia and a number of bone marrow...
action specifically targets the fast-dividing cells, and tend to have adverse effects on the bone marrow, skin, and hair. As folate is vital in the first...
targeting the folate receptor. It is currently in clinical trials for platinum-resistant ovarian cancer (PROCEED trial) and a Phase 2b study (TARGET trial)...
systems. The most common use of immunoliposomes is to target cancer cells using different antibodies. Folate receptors and transferrin receptors are typically...
Folate transporter 1 is a protein which in humans is encoded by the SLC19A1 gene. Transport of folate compounds into mammalian cells can occur via receptor-mediated...
membrane antigen (PSMA) is an enzyme that in humans is encoded by the FOLH1 (folate hydrolase 1) gene. Human GCPII contains 750 amino acids and weighs approximately...
synthase. (Note that homocysteine can also be converted to methionine by the folate-independent enzyme betaine-homocysteine methyltransferase (BHMT).) MTHFR...
organisms require reduced folate cofactors for the synthesis of a variety of metabolites. Most microorganisms must synthesize folate de novo because they lack...
spinal cord strongly suggests the presence of a B12 deficiency instead of folate deficiency. Methylmalonic acid, if not properly handled by B12, remains...
were synthesized (SERRS). One of the SERRS was a "targeted nanoprobe functionalized with an anti-folate-receptor antibody (αFR-Ab) via a PEG-maleimide-succinimide...
number NCT04241315 for "ELUCIDATE: Enabling Lung Cancer Identification Using Folate Receptor Targeting (Elucidate)" at ClinicalTrials.gov Portal: Medicine...
move folate into the cell against its concentration gradient. The RFC protein can transport folates, reduced folates, the derivatives of reduced folate, and...
precursor for the production of folates. Folates are family of cofactors that are essential for living organisms. Folate cofactors are used in several one-carbon...
Numerous targeting moieties have been used to modify dendrimer biodistribution and allow for targeting to specific organs. For example, folate receptors...
It is decreased with methyl folate trapping, where it is accompanied by decreased methylmalonic acid, increased folate, and a decrease in formiminoglutamic...
untreated in infants, deficiency may lead to neurological damage and anemia. Folate levels in the individual may affect the course of pathological changes and...
Dihydropteroate is an important intermediate in folate biosynthesis. It is a pterin created from para-aminobenzoic acid (PABA) by the enzyme dihydropteroate...
accumulation of levomefolic acid. This accumulation depletes the other types of folate required for purine and thymidylate synthesis, which are required for the...
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