Matuzumab (formerly EMD 72000) is a humanized monoclonal antibody for the treatment of cancer. It binds to the epidermal growth factor receptor (EGFR) with high affinity.[1] The mouse monoclonal antibody (mAb425) from which matuzumab was developed at the Wistar Institute in Philadelphia, Pennsylvania [2]
Produced and developed by Merck Serono in cooperation with Takeda Pharmaceutical, it has undergone phase II clinical trials for the treatment of colorectal, lung,[3] esophageal and stomach cancer[4] early in the 2000s. In August 2007, Merck Serono announced that the preliminary results of the colorectal cancer study were less than promising, and that further trials for treating this type of cancer may be abandoned.[5] In February 2008, the development was halted because of disappointing study results.[6]
^Murthy U, Basu A, Rodeck U, Herlyn M, Ross AH, Das M (February 1987). "Binding of an antagonistic monoclonal antibody to an intact and fragmented EGF-receptor polypeptide". Archives of Biochemistry and Biophysics. 252 (2): 549–60. doi:10.1016/0003-9861(87)90062-2. PMID 2434025.
^Rodeck U, Herlyn M, Herlyn D, Molthoff C, Atkinson B, Varello M, et al. (July 1987). "Tumor growth modulation by a monoclonal antibody to the epidermal growth factor receptor: immunologically mediated and effector cell-independent effects". Cancer Research. 47 (14): 3692–6. PMID 3297307.
^Clinical trial number NCT00111839 for "Effects of Matuzumab in Combination With Pemetrexed for the Treatment of Advanced Lung Cancer" at ClinicalTrials.gov
^Clinical trial number NCT00215644 for "MATRIX EG (Matuzumab Treatment With ECX in Esophago-Gastric Cancer)" at ClinicalTrials.gov
^"Krebsmedikament floppt" [Cancer drug flops] (in German). n-tv. August 29, 2007. Retrieved August 27, 2007.
^Cite error: The named reference Merck was invoked but never defined (see the help page).
Matuzumab (formerly EMD 72000) is a humanized monoclonal antibody for the treatment of cancer. It binds to the epidermal growth factor receptor (EGFR)...
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