Splenic marginal zone lymphoma (SMZL) is a type of marginal zone lymphoma, a cancer made up of B-cells that replace the normal architecture of the white pulp of the spleen. The neoplastic cells are both small lymphocytes and larger, transformed lymphoblasts, and they invade the mantle zone of splenic follicles and erode the marginal zone, ultimately invading the red pulp of the spleen. Frequently, the bone marrow and splenic hilar lymph nodes are involved along with the peripheral blood. The neoplastic cells circulating in the peripheral blood are termed villous lymphocytes due to their characteristic appearance.[1]
^Elaine Sarkin Jaffe, Nancy Lee Harris, World Health Organization, International Agency for Research on Cancer, Harald Stein, J.W. Vardiman (2001). Pathology and genetics of tumours of haematopoietic and lymphoid tissues. World Health Organization Classification of Tumors. Vol. 3. Lyon: IARC Press. ISBN 978-92-832-2411-2.{{cite book}}: CS1 maint: multiple names: authors list (link)
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MALT lymphomas. Splenicmarginalzonelymphomas (SMZLs) are MZLs that initially are confined to the spleen, bone marrow, and blood. Nodal marginalzone lymphomas...
appearance include mantle cell lymphoma, marginalzonelymphoma, B cell prolymphocytic leukemia, and lymphoplasmacytic lymphoma. B cell prolymphocytic leukemia...
the most common of which is follicular lymphoma. Others include cutaneous T-cell lymphoma, marginalzonelymphoma, chronic lymphocytic leukemia, and Waldenström...
identical to splenicmarginalzonelymphoma, or only highly similar, is a matter of debate. Maslak, Peter (1 September 2007). "Splenic villous lymphoma—peripheral...
>1000 g) are chronic myelogenous leukemia myelofibrosis malaria splenicmarginalzonelymphoma Splenomegaly can be classified based on its pathophysiologic...
Birte; Timphus, Eva Maria; Barth, Peter J. (December 2006). "The splenicmarginalzone in humans and rodents: an enigmatic compartment and its inhabitants"...
malignancies Lymphomas Hodgkin's disease Non-Hodgkin's lymphoma {includes the next five entries} Burkitt's lymphoma Anaplastic large cell lymphomaSplenic marginal...
HCL and also the absence of any additional diseases, such as Splenicmarginalzonelymphoma or B-cell prolymphocytic leukemia. The diagnosis can be confirmed...
processing. Decreased expression of this gene is associated with splenicmarginalzonelymphomas. GRCh38: Ensembl release 89: ENSG00000127920 – Ensembl, May...
is an anti-cancer medication for the treatment of marginalzonelymphoma (MZL) and follicular lymphoma (FL). It is taken by mouth. Umbralisib is a kinase...
cell leukemia variant, a fraction of splenicmarginalzonelymphomas, and enteropathy-associated T cell lymphoma. The chief ligand for αEβ7 is E-cadherin...
granted orphan drug status for the treatment of splenic, nodal and extranodal subtypes of marginalzonelymphoma. "Aliqopa- copanlisib injection, powder, lyophilized...
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