Manolis Kellis (Greek: Μανώλης Καμβυσέλλης; born 1977) is a professor of Computer Science and Computational Biology at the Massachusetts Institute of Technology (MIT) and a member of the Broad Institute of MIT and Harvard.[3] He is the head of the Computational Biology Group at MIT[4] and is a Principal Investigator in the Computer Science and Artificial Intelligence Lab (CSAIL) at MIT.[5]
Kellis is known for his contributions to genomics, human genetics, epigenomics, gene regulation, genome evolution, disease mechanism, and single-cell genomics. He co-led the NIH Roadmap Epigenomics Project[6] effort to create a comprehensive map of the human epigenome,[7][8][9] the comparative analysis of 29 mammals to create a comprehensive map of conserved elements in the human genome,[10][11] the ENCODE, GENCODE, and modENCODE projects to characterize the genes, non-coding elements, and circuits of the human genome and model organisms.[12][13][14] A major focus of his work is understanding the effects of genetic variations on human disease,[15] with contributions to obesity,[16][17][18] diabetes,[19] Alzheimer's disease,[20][21][22] schizophrenia,[23] and cancer.[24]
^Cite error: The named reference gs was invoked but never defined (see the help page).
^Cite error: The named reference :1 was invoked but never defined (see the help page).
^"Researchers generate a reference map of the human epigenome". MIT News. Retrieved 2018-07-18.
^"Researchers generate a reference map of the human epigenome". MIT News. Retrieved 2018-07-19.
^Lindblad-Toh, Kerstin; Garber, Manuel; Zuk, Or; Lin, Michael F.; Parker, Brian J.; Washietl, Stefan; Kheradpour, Pouya; Ernst, Jason; Kellis, Manolis (2011). "A high-resolution map of human evolutionary constraint using 29 mammals". Nature. 478 (7370): 476–482. Bibcode:2011Natur.478..476.. doi:10.1038/nature10530. ISSN 0028-0836. PMC 3207357. PMID 21993624.
^"Analysis of 29 mammals reveals genomic 'dark matter'". MIT News. Retrieved 2018-07-21.
^Kellis, Manolis; Wold, Barbara; Snyder, Michael P.; Bernstein, Bradley E.; Kundaje, Anshul; Marinov, Georgi K.; Ward, Lucas D.; Birney, Ewan; Crawford, Gregory E. (2014-04-29). "Defining functional DNA elements in the human genome". Proceedings of the National Academy of Sciences. 111 (17): 6131–6138. Bibcode:2014PNAS..111.6131K. doi:10.1073/pnas.1318948111. ISSN 0027-8424. PMC 4035993. PMID 24753594.
^Ernst, Jason; Kheradpour, Pouya; Mikkelsen, Tarjei S.; Shoresh, Noam; Ward, Lucas D.; Epstein, Charles B.; Zhang, Xiaolan; Wang, Li; Issner, Robbyn (2011-03-23). "Mapping and analysis of chromatin state dynamics in nine human cell types". Nature. 473 (7345): 43–49. Bibcode:2011Natur.473...43E. doi:10.1038/nature09906. ISSN 0028-0836. PMC 3088773. PMID 21441907.
^Consortium, The modENCODE; Roy, Sushmita; Ernst, Jason; Kharchenko, Peter V.; Kheradpour, Pouya; Negre, Nicolas; Eaton, Matthew L.; Landolin, Jane M.; Bristow, Christopher A. (2010-12-24). "Identification of Functional Elements and Regulatory Circuits by Drosophila modENCODE". Science. 330 (6012): 1787–1797. Bibcode:2010Sci...330.1787R. doi:10.1126/science.1198374. ISSN 0036-8075. PMC 3192495. PMID 21177974.
^Cite error: The named reference :2 was invoked but never defined (see the help page).
^"Identifying the gene switch that turns fat cells bad". Science | AAAS. 2015-08-19. Retrieved 2018-07-19.
^"A Fat-Burning Gene May Help Weight Loss". Time. Retrieved 2018-07-19.
^Claussnitzer, Melina; Dankel, Simon N.; Kim, Kyoung-Han; Quon, Gerald; Meuleman, Wouter; Haugen, Christine; Glunk, Viktoria; Sousa, Isabel S.; Kellis, Manolis (2015-09-03). "FTO Obesity Variant Circuitry and Adipocyte Browning in Humans". New England Journal of Medicine. 373 (10): 895–907. doi:10.1056/nejmoa1502214. ISSN 0028-4793. PMC 4959911. PMID 26287746.
^Onengut-Gumuscu, Suna; Chen, Wei-Min; Burren, Oliver; Cooper, Nick J; Quinlan, Aaron R; Mychaleckyj, Josyf C; Farber, Emily; Bonnie, Jessica K; Kellis, Manolis (2015-03-09). "Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers". Nature Genetics. 47 (4): 381–386. doi:10.1038/ng.3245. ISSN 1061-4036. PMC 4380767. PMID 25751624.
ManolisKellis (Greek: Μανώλης Καμβυσέλλης; born 1977) is a professor of Computer Science and Computational Biology at the Massachusetts Institute of Technology...
doctoral students include Serafim Batzoglou, Lior Pachter, Mona Singh, ManolisKellis, and Phil Bradley. Berger has served as vice president of the International...
Smith, Casey Bergman, Brian Oliver, Therese Ann Markow, Thomas Kaufman, ManolisKellis, William Gelbart, Venky Iyer, Daniel Pollard, Timothy Sackton, Amanda...
became a postdoctoral researcher in the groups of Eric S. Lander and ManolisKellis at the Broad Institute of MIT and Harvard University and the MIT Computer...
of cultural anthropology Constantine John Alexopoulos – mycologist ManolisKellis – genomics, computational biology, AI Tom Maniatis – biologist Aristides...
Dynabook, Smalltalk, overlapping windows Neeraj Kayal – AKS primality test ManolisKellis – computational biology John George Kemeny – the language BASIC Ken...
F Costello; Bing Ren; Aleksandar Milosavljevic; Alexander Meissner; ManolisKellis; Marco A Marra; Arthur L Beaudet; Joseph R Ecker; Peggy J Farnham; Martin...
CELS.2019.09.008. ISSN 2405-4712. PMID 31629685. Wikidata Q90821356. ManolisKellis; Barbara Wold; Michael P Snyder; et al. (29 April 2014). "Defining functional...
(PI), Centre de Regulació Genòmica (CRG), Barcelona, Catalonia, Spain ManolisKellis (PI), Massachusetts Institute of Technology (MIT), Boston, USA Mark...
Technology Alfredo Fontanini, State University of New York, Stony Brook ManolisKellis, Massachusetts Institute of Technology Jessica Y. Lee, University of...
Cristian Ashmore, Lillian Bertol, Jessica W. Fakhouri, Walid D. Yu, Fuli Kellis, Manolis Gerstein, Mark Milosavljevic, Aleksandar (2019-06-07). Allele-specific...
708W. doi:10.1038/42711. ISSN 0028-0836. PMID 9192896. S2CID 4307263. Kellis, Manolis; Birren, Bruce W.; Lander, Eric S. (2004-04-08). "Proof and evolutionary...
Heitman, Joseph; Gow, Neil A. R.; Lorenz, Michael C.; Birren, Bruce W.; Kellis, Manolis; Cuomo, Christina A. (24 May 2009). "Evolution of pathogenicity and...
Meroitic, X-Group and Christian period inhabitants of Lower Nubia, and the Kellis population in the Dakhla Oasis.: 219–20 Among the recent groups, the Badari...
a Kellis 2 cemetery which was "occupied during the Late Ptolemaic through Roman periods" and found the "brachial and crural indices" of the Kellis 2 samples...
the original (PDF) on 22 October 2017. Retrieved 1 May 2018. Kogevinas, Manolis; Gwinn, William M.; Kriebel, David; Phillips, David H.; Sim, Malcolm; Bertke...