Global InformationAmy Gladfelter information
Amy S. Gladfelter | |
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| Born | April 27, 1974 Philadelphia, Pennsylvania, U.S. |
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| Children | 2[4] |
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| Scientific career | |
| Fields | Cell biology, Biophysics, Molecular Biology |
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| Website | mgm |
Amy S. Gladfelter (born April 27, 1974) is an American quantitative cell biologist who is interested in understanding fundamental mechanisms of cell organization. She was a Professor of Biology and the Associate Chair for Diversity Initiatives at the University of North Carolina at Chapel Hill, before moving to Department of Cell Biology at Duke University.[5] She investigates cell cycle control and the septin cytoskeleton.[6] She is also affiliated with the Lineberger Comprehensive Cancer Center and is a fellow of the Marine Biological Laboratory in Woods Hole, MA.
Gladfelter studies the spatial organization of multinucleate cells, also called syncytia, which are cells with many nuclei that share a common cytoplasm. Her lab at Duke University is broadly interested in understanding why syncytia have arisen in diverse contexts within the tree of life.[7][8][9][10] Syncytial cells are found throughout the human body, including in bone, blood, muscle, and placental tissue, and throughout the natural world, including in fungi, algae and in many animals during their development. Many tumors become syncytial, while certain viruses, including SARS-CoV-2, can induce cells to fuse. Additionally, Gladfelter studies the assembly of the septin cytoskeleton and how aberrant septin structure affects its function.[11][12][13][14][15][16] Her research program uses microscopy, biophysical and genetic approaches to study cell biology.
- ^ "The 2016 Faculty Scholars". Howard Hughes Medical Institute. Retrieved November 30, 2017.
- ^ "Faculty Mentoring Award". Dartmouth. Archived from the original on December 28, 2017. Retrieved November 30, 2017.
- ^ Cite error: The named reference
DMwas invoked but never defined (see the help page). - ^ Sedwick, Caitlin (February 17, 2014). "Amy Gladfelter: Fungi with a streak of individuality". Journal of Cell Biology. 204 (4): 464–465. doi:10.1083/jcb.2044pi. PMC 3926962. PMID 24535821.
- ^ "The Gladfelter Lab". The Gladfelter Lab. Retrieved February 15, 2024.
- ^ "The Gladfelter Lab". The University of North Carolina at Chapel Hill. Retrieved November 30, 2017.
- ^ "Research Questions". The Gladfelter Lab. Retrieved October 8, 2019.
- ^ Lee, Changhwan; Zhang, Huaiying; Baker, Amy E.; Occhipinti, Patricia; Borsuk, Mark E.; Gladfelter, Amy S. (June 24, 2013). "Protein aggregation behavior regulates cyclin transcript localization and cell-cycle control". Developmental Cell. 25 (6): 572–584. doi:10.1016/j.devcel.2013.05.007. ISSN 1878-1551. PMC 4113091. PMID 23769973.
- ^ Zhang, Huaiying; Elbaum-Garfinkle, Shana; Langdon, Erin M.; Taylor, Nicole; Occhipinti, Patricia; Bridges, Andrew A.; Brangwynne, Clifford P.; Gladfelter, Amy S. (October 15, 2015). "RNA Controls PolyQ Protein Phase Transitions". Molecular Cell. 60 (2): 220–230. doi:10.1016/j.molcel.2015.09.017. ISSN 1097-4164. PMC 5221516. PMID 26474065.
- ^ Langdon, Erin M.; Qiu, Yupeng; Ghanbari Niaki, Amirhossein; McLaughlin, Grace A.; Weidmann, Chase A.; Gerbich, Therese M.; Smith, Jean A.; Crutchley, John M.; Termini, Christina M.; Weeks, Kevin M.; Myong, Sua (May 25, 2018). "mRNA structure determines specificity of a polyQ-driven phase separation". Science. 360 (6391): 922–927. Bibcode:2018Sci...360..922L. doi:10.1126/science.aar7432. ISSN 1095-9203. PMC 6192030. PMID 29650703.
- ^ Gladfelter, Amy S.; Bose, Indrani; Zyla, Trevin R.; Bardes, Elaine S. G.; Lew, Daniel J. (January 21, 2002). "Septin ring assembly involves cycles of GTP loading and hydrolysis by Cdc42p". The Journal of Cell Biology. 156 (2): 315–326. doi:10.1083/jcb.200109062. ISSN 0021-9525. PMC 2199227. PMID 11807094.
- ^ DeMay, Bradley S.; Meseroll, Rebecca A.; Occhipinti, Patricia; Gladfelter, Amy S. (April 2009). "Regulation of distinct septin rings in a single cell by Elm1p and Gin4p kinases". Molecular Biology of the Cell. 20 (8): 2311–2326. doi:10.1091/mbc.e08-12-1169. ISSN 1939-4586. PMC 2669037. PMID 19225152.
- ^ DeMay, Bradley S.; Bai, Xiaobo; Howard, Louisa; Occhipinti, Patricia; Meseroll, Rebecca A.; Spiliotis, Elias T.; Oldenbourg, Rudolf; Gladfelter, Amy S. (June 13, 2011). "Septin filaments exhibit a dynamic, paired organization that is conserved from yeast to mammals". The Journal of Cell Biology. 193 (6): 1065–1081. doi:10.1083/jcb.201012143. ISSN 1540-8140. PMC 3115802. PMID 21670216.
- ^ Meseroll, Rebecca A.; Occhipinti, Patricia; Gladfelter, Amy S. (February 2013). "Septin phosphorylation and coiled-coil domains function in cell and septin ring morphology in the filamentous fungus Ashbya gossypii". Eukaryotic Cell. 12 (2): 182–193. doi:10.1128/EC.00251-12. ISSN 1535-9786. PMC 3571309. PMID 23204191.
- ^ Bridges, Andrew A.; Zhang, Huaiying; Mehta, Shalin B.; Occhipinti, Patricia; Tani, Tomomi; Gladfelter, Amy S. (February 11, 2014). "Septin assemblies form by diffusion-driven annealing on membranes". Proceedings of the National Academy of Sciences of the United States of America. 111 (6): 2146–2151. Bibcode:2014PNAS..111.2146B. doi:10.1073/pnas.1314138111. ISSN 1091-6490. PMC 3926015. PMID 24469790.
- ^ McQuilken, Molly; Jentzsch, Maximilian S.; Verma, Amitabh; Mehta, Shalin B.; Oldenbourg, Rudolf; Gladfelter, Amy S. (2017). "Analysis of Septin Reorganization at Cytokinesis Using Polarized Fluorescence Microscopy". Frontiers in Cell and Developmental Biology. 5: 42. doi:10.3389/fcell.2017.00042. ISSN 2296-634X. PMC 5413497. PMID 28516085.