A rendering of an icosahedral viral capsid comprising 72 pentamers of murine polyomavirus VP1, colored such that areas of the surface closer to the interior center appear blue and areas further away appear red. Rendered from PDB: 1SIE.
Identifiers
Symbol
VP1
Pfam
PF00718
InterPro
IPR000662
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
Major capsid protein VP1 is a viral protein that is the main component of the polyomavirus capsid. VP1 monomers are generally around 350 amino acids long and are capable of self-assembly into an icosahedral structure consisting of 360 VP1 molecules organized into 72 pentamers. VP1 molecules possess a surface binding site that interacts with sialic acids attached to glycans, including some gangliosides, on the surfaces of cells to initiate the process of viral infection. The VP1 protein, along with capsid components VP2 and VP3, is expressed from the "late region" of the circular viral genome.[1][2][3]
^Ramqvist T, Dalianis T (August 2009). "Murine polyomavirus tumour specific transplantation antigens and viral persistence in relation to the immune response, and tumour development". Seminars in Cancer Biology. 19 (4): 236–43. doi:10.1016/j.semcancer.2009.02.001. PMID 19505651.
^Ramqvist T, Dalianis T (February 2010). "Lessons from immune responses and vaccines against murine polyomavirus infection and polyomavirus-induced tumours potentially useful for studies on human polyomaviruses". Anticancer Research. 30 (2): 279–84. PMID 20332429.
^Buch MH, Liaci AM, O'Hara SD, Garcea RL, Neu U, Stehle T (October 2015). "Structural and Functional Analysis of Murine Polyomavirus Capsid Proteins Establish the Determinants of Ligand Recognition and Pathogenicity". PLOS Pathogens. 11 (10): e1005104. doi:10.1371/journal.ppat.1005104. PMC 4608799. PMID 26474293.
and 28 Related for: Major capsid protein VP1 information
MajorcapsidproteinVP1 is a viral protein that is the main component of the polyomavirus capsid. VP1 monomers are generally around 350 amino acids long...
has faces consisting of three proteins named VP1–3. Some viruses are enveloped, meaning that the capsid is coated with a lipid membrane known as the viral...
the capsids of several virus families MajorcapsidproteinVP1, a main component of the polyomavirus capsidVP1, a virtual machine architecture conceptually...
capsid. Polyomavirus capsids are composed of three proteins; the major component is majorcapsidproteinVP1, which self-assembles into pentamers that in turn...
The P24 capsidprotein is the most abundant HIV protein with each virus containing approximately 1,500 to 3,000 p24 molecules. It is the major structural...
is used in biochemistry for oligomers of proteins that are not covalently bound. The majorcapsidproteinVP1 that comprises the shell of the polio virus...
polyomavirus capsid consists of one major component, majorcapsidproteinVP1, and one or two minor components, minor capsidproteins VP2 and VP3. VP1 pentamers...
the VP1-protein, the so-called VP1-unique region. VP2 is the majorcapsidprotein, and comprises approximately 95% of the total virus particle. VP1-proteins...
composed of a capsid that contains four viral proteins, VP1, VP2, VP3 and VP4. VP1, VP2, and VP3 form the major part of the proteincapsid. The much smaller...
closely resembles VP1 from polyomaviruses. Intermolecular disulphide bonding holds the L1 capsidproteins together. L1 capsidproteins can bind via its...
non-structural proteins (NS1/2 to NS7) by the viral 3C-like protease (NS6), a major structural protein (VP1) of about 58~60 kDa and a minor capsidprotein (VP2)...
two genes encoding for a replication initiator protein, called NS1, and the protein the viral capsid is made of. The coding portion of the genome is...
trichohyalin granules. Antibodies against majorcapsidproteinVP1, the major component of the viral capsid, can be used to confirm the presence of viral...
polyomaviruses, encoding five viral proteins: three capsid components, majorcapsidproteinVP1, VP2, and VP3; and two additional proteins involved in replication...
polyomaviruses, encoding five viral proteins: three capsid components, majorcapsidproteinVP1, VP2, and VP3; and two additional proteins involved in replication...
(June 15, 1998). "Interaction of polyomavirus internal protein VP2 with the majorcapsidproteinVP1 and implications for participation of VP2 in viral entry"...
cleaved into three proteins . Segment B encodes a single viral protein, VP1. Viral protein 1 is an RNA-dependent RNA polymerase, which cycles between the...
studies suggesting that the evolutionary histories of LTag and majorcapsidproteinVP1 are divergent and that some modern polyomavirus represent chimeric...
C-terminal hexapeptides can be added. The R3 transcript produces capsidproteinsVP1 and VP2, which requires transcription from the P38 promoter, in contrast...
EV-D68, EV-B69, EV-D70, EV-A71, etc., where genotyping is based on the VP1capsid region. Enteroviruses affect millions of people worldwide each year and...
polymerase enzyme made of VP1. The composition of the surface of virus particles involves a specific area of the capsidprotein VP2 linked to host specificity...
enveloped. There are six viral proteins (VPs) that form the virus particle (virion). These structural proteins are called VP1, VP2, VP3, VP4, VP6 and VP7...
suggest different ancestries for the large tumor antigen and the majorcapsidproteinVP1, implying that the virus might have evolved from an ancestral recombination...
Four structural proteins comprise the capsid: VP1, VP2, VP3, and VP4. VP1, VP2, and VP3 compose the main structural units of the capsid while VP4 is not...
composed of a '2 to 5 capsidprotein subunit aggregate', arranged in a helical capsid structure. The Icosahedral capsid structure is majorly dependent on the...
suggests different ancestries for the large tumor antigen and the majorcapsidproteinVP1, implying that the virus might have evolved from an ancestral recombination...
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