MYO7A information

MYO7A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3PVL
Identifiers
Aliases	MYO7A, DFNA11, DFNB2, MYOVIIA, MYU7A, NSRD2, USH1B, myosin VIIA
External IDs	OMIM: 276903; MGI: 104510; HomoloGene: 219; GeneCards: MYO7A; OMA:MYO7A - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	77,215,241 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	97,768,731 bp
RNA expression pattern
	Top expressed in
	right adrenal cortex; ; left adrenal gland; ; left adrenal cortex; ; left testis; ; right lobe of liver; ; right testis; ; anterior pituitary; ; spleen; ; paraflocculus of cerebellum; ; frontal pole;
	Top expressed in
	fourth ventricle; ; choroid plexus of fourth ventricle; ; Ileal epithelium; ; stroma of bone marrow; ; adrenal gland; ; yolk sac; ; retinal pigment epithelium; ; choroidal fissure; ; Epithelium of choroid plexus; ; iris;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; spectrin binding; protein homodimerization activity; protein domain specific binding; ADP binding; calmodulin binding; microfilament motor activity; protein binding; actin binding; cytoskeletal motor activity; ATP binding; microtubule motor activity; microtubule binding; actin filament binding; protein-containing complex binding; protein N-terminus binding;
Cellular component	cytosol; photoreceptor inner segment; melanosome; photoreceptor outer segment; stereocilium; photoreceptor connecting cilium; microvillus; lysosomal membrane; cell cortex; apical plasma membrane; myosin VII complex; upper tip-link density; cytoskeleton; myosin complex; synapse; cytoplasm; stereocilium base;
Biological process	sensory perception; inner ear receptor cell stereocilium organization; pigment granule localization; sensory perception of light stimulus; post-embryonic animal organ morphogenesis; hearing; mechanoreceptor differentiation; pigment granule transport; auditory receptor cell stereocilium organization; phagolysosome assembly; inner ear auditory receptor cell differentiation; cell projection organization; equilibrioception; inner ear morphogenesis; eye photoreceptor cell development; phagocytosis; inner ear development; inner ear receptor cell differentiation; intracellular protein transport; lysosome organization; visual perception; actin filament-based movement; microtubule-based movement;
	Sources:Amigo / QuickGO
Orthologs
	4647
	17921
	ENSG00000137474
	ENSMUSG00000030761
	Q13402
	P97479
	NM_000260; NM_001127179; NM_001127180; NM_001369365
	NM_001256081; NM_001256082; NM_001256083; NM_008663
	NP_000251; NP_001120652; NP_001356294
	NP_001243010; NP_001243011; NP_001243012; NP_032689
	Wikidata
View/Edit Human	View/Edit Mouse

Myosin VIIA is protein that in humans is encoded by the MYO7A gene.^[5] Myosin VIIA is a member of the unconventional myosin superfamily of proteins.^[6] Myosins are actin binding molecular motors that use the enzymatic conversion of ATP - ADP + inorganic phosphate (Pi) to provide the energy for movement.

Myosins are mechanochemical proteins characterized by the presence of a motor domain, an actin-binding domain, a neck domain that interacts with other proteins, and a tail domain that serves as an anchor. Myosin VIIA is an unconventional myosin with the longest tail (1360 aa). The tail is expected to dimerize, resulting in a two-headed molecule. Unconventional myosins have diverse functions in eukaryotic cells and are primarily thought to be involved in the movement or linkage of intra-cellular membranes and organelles to the actin cytoskeleton via interactions mediated by their highly divergent tail domains.

MYO7A is expressed in a number of mammalian tissues, including testis, kidney, lung, inner ear, retina and the ciliated epithelium of the nasal mucosa.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000137474 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030761 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hasson T, Skowron JF, Gilbert DJ, Avraham KB, Perry WL, Bement WM, Anderson BL, Sherr EH, Chen ZY, Greene LA, Ward DC, Corey DP, Mooseker MS, Copeland NG, Jenkins NA (September 1996). "Mapping of unconventional myosins in mouse and human". Genomics. 36 (3): 431–9. doi:10.1006/geno.1996.0488. PMID 8884266.
^ Weil D, Blanchard S, Kaplan J, Guilford P, Gibson F, Walsh J, Mburu P, Varela A, Levilliers J, Weston MD (March 1995). "Defective myosin VIIA gene responsible for Usher syndrome type 1B". Nature. 374 (6517): 60–1. Bibcode:1995Natur.374...60W. doi:10.1038/374060a0. PMID 7870171. S2CID 4324416.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000137474 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030761 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8884266-5] Hasson T, Skowron JF, Gilbert DJ, Avraham KB, Perry WL, Bement WM, Anderson BL, Sherr EH, Chen ZY, Greene LA, Ward DC, Corey DP, Mooseker MS, Copeland NG, Jenkins NA (September 1996). "Mapping of unconventional myosins in mouse and human". Genomics. 36 (3): 431–9. doi:10.1006/geno.1996.0488. PMID 8884266.

[pmid7870171-6] Weil D, Blanchard S, Kaplan J, Guilford P, Gibson F, Walsh J, Mburu P, Varela A, Levilliers J, Weston MD (March 1995). "Defective myosin VIIA gene responsible for Usher syndrome type 1B". Nature. 374 (6517): 60–1. Bibcode:1995Natur.374...60W. doi:10.1038/374060a0. PMID 7870171. S2CID 4324416.

MYO7A information

and 26 Related for: MYO7A information

MYO7A

Keratin

List of genetic disorders

Troponin I

Kinesin

Usher syndrome

Troponin

Filaggrin

Tau protein

Actin

Intermediate filament

Myofilament

Tubulin

Vimentin

Myosin

Nonsyndromic deafness

Troponin T

Glial fibrillary acidic protein

KIF21B

Tropomyosin

Microfilament

Cytokeratin

KIF26A

Dystrophin

Tonofibril

Lamin