MXD4 information

MXD4
Identifiers
Aliases	MXD4, MAD4, MST149, MSTP149, bHLHc12, MAX dimerization protein 4
External IDs	MGI: 104991; HomoloGene: 4712; GeneCards: MXD4; OMA:MXD4 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	2,262,109 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	34,345,064 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; anterior pituitary; ; right lung; ; apex of heart; ; right adrenal cortex; ; Descending thoracic aorta; ; tibial nerve; ; ascending aorta; ; right coronary artery; ; right lobe of thyroid gland;
	Top expressed in
	ascending aorta; ; aortic valve; ; Paneth cell; ; fossa; ; Rostral migratory stream; ; left lung lobe; ; calvaria; ; vestibular sensory epithelium; ; thymus; ; vestibular membrane of cochlear duct;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein binding; protein dimerization activity; transcription corepressor activity; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; negative regulation of cell population proliferation;
	Sources:Amigo / QuickGO
Orthologs
	10608
	17122
	ENSG00000123933
	ENSMUSG00000037235
	Q14582
	Q60948
	NM_006454
	NM_010753
	NP_006445
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Max-interacting transcriptional repressor MAD4 is a protein that in humans is encoded by the MXD4 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000123933 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037235 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hurlin PJ, Quéva C, Koskinen PJ, Steingrímsson E, Ayer DE, Copeland NG, Jenkins NA, Eisenman RN (November 1995). "Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation". The EMBO Journal. 14 (22): 5646–59. doi:10.1002/j.1460-2075.1995.tb00252.x. PMC 394680. PMID 8521822.
^ "Entrez Gene: MXD4 MAX dimerization protein 4".

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