Mitochondrial myopathy, encephalomyopathy, lactic acidosis, and stroke-like episodes
Basal ganglia calcification, cerebellar atrophy, increased lactate; a CT image of a person diagnosed with MELAS
Specialty
Neurology
Frequency
1 in 4000[1]
Mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) is one of the family of mitochondrial diseases, which also include MIDD (maternally inherited diabetes and deafness), MERRF syndrome, and Leber's hereditary optic neuropathy. It was first characterized under this name in 1984.[2] A feature of these diseases is that they are caused by defects in the mitochondrial genome which is inherited purely from the female parent.[3] The most common MELAS mutation is mitochondrial mutation, mtDNA, referred to as m.3243A>G.
^Pia S, Lui F (2020). "Melas Syndrome". Statpearls. Treasure Island (FL): StatPearls Publishing. PMID 30422554. Text was copied from this source, which is available under a Creative Commons Attribution 4.0 International License.
^Pavlakis SG, Phillips PC, DiMauro S, De Vivo DC, Rowland LP (October 1984). "Mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes: a distinctive clinical syndrome". Annals of Neurology. 16 (4): 481–488. doi:10.1002/ana.410160409. PMID 6093682. S2CID 41412358.
^Hirano M, Pavlakis SG (January 1994). "Mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes (MELAS): current concepts". Journal of Child Neurology. 9 (1): 4–13. doi:10.1177/088307389400900102. PMID 8151079. S2CID 31329972.
episodes (MELAS) is one of the family of mitochondrial diseases, which also include MIDD (maternally inherited diabetes and deafness), MERRF syndrome, and...
syndrome. This is not common since the advent of phototherapy. Succinic acid has been studied, and shown effective for both Leigh syndrome, and MELAS...
happens in some genetic mitochondrial diseases, such as Leigh syndrome, and Melassyndrome, and degradation can lead to pathological conditions, such as...
Diseases caused by mutation in the mtDNA include Kearns–Sayre syndrome, MELASsyndrome and Leber's hereditary optic neuropathy. In the vast majority of...
CVS are characteristic of the MELASsyndrome. An A3243G mtDNA mutation has been found in 80% of patients with this syndrome, and has also been described...
Look up melas, mêlas, mēļas, or mēļās in Wiktionary, the free dictionary. Melas may refer to: Plural of melaMelas (mythology), a number of different characters...
545000 Zeviani M, Muntoni F, Savarese N, et al. (1993). "A MERRF/MELAS overlap syndrome associated with a new point mutation in the mitochondrial DNA tRNA(Lys)...
associated with a mitochondrial disease. MELASsyndrome Examples include MELASsyndrome and MERRF syndrome. These conditions can sometimes present together...
1086/444436. PMC 1226206. PMID 16080116. Hwang, Jung-Hee (20 June 2008). "A MELASsyndrome family harboring two mutations in mitochondrial genome". Experimental...
some of these genes have been associated with severe diseases like the MELASsyndrome. Regions in nuclear chromosomes, very similar in sequence to mitochondrial...
signal consistent with diffusion restriction in a patient with known MELASsyndrome Another application area of DWI is in oncology. Tumors are in many instances...
suffered from a chronic illness that has been speculated to have been MELASsyndrome (a mitochondrial myopathy). Bioenergetic systems Exercise intolerance...
Filippo may refer to: San Filippo syndrome, rare autosomal recessive lysosomal storage disease San Filippo del Mela, comune in the Metropolitan City of...
are MELAS, MERF, KSS, CPEO, and MNGIE which are listed below: Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like syndrome (MELAS) Varying...
Global Information
Text was copied from this source, which is available under a Creative Commons Attribution 4.0 International License.
