MAP1LC3A information

MAP1LC3A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3ECI, 3WAL, 3WAN, 4ZDV
Identifiers
Aliases	MAP1LC3A, ATG8E, LC3, LC3A, MAP1ALC3, MAP1BLC3, microtubule associated protein 1 light chain 3 alpha
External IDs	OMIM: 601242; MGI: 1915661; HomoloGene: 12021; GeneCards: MAP1LC3A; OMA:MAP1LC3A - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	34,560,345 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	155,119,993 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; right frontal lobe; ; Brodmann area 9; ; cingulate gyrus; ; anterior cingulate cortex; ; prefrontal cortex; ; hypothalamus; ; C1 segment; ; amygdala; ; anterior pituitary;
	Top expressed in
	lip; ; muscle of thigh; ; right ventricle; ; dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; primary visual cortex; ; seminiferous tubule; ; dorsomedial hypothalamic nucleus; ; digastric muscle; ; triceps brachii muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	phosphatidylethanolamine binding; protein binding; phospholipid binding; ubiquitin protein ligase binding; microtubule binding;
Cellular component	cytoplasm; organelle membrane; cytosol; late endosome; membrane; autophagosome; microtubule; cytoskeleton; cytoplasmic vesicle; endomembrane system; autolysosome; autophagosome membrane; synapse;
Biological process	autophagy; autophagy of mitochondrion; autophagosome assembly; response to iron(II) ion; response to lead ion; response to nutrient levels; cellular response to amino acid starvation; response to morphine; cellular response to hydrogen peroxide; cellular response to copper ion; cellular response to nitrogen starvation; cellular response to starvation; macroautophagy; autophagosome maturation;
	Sources:Amigo / QuickGO
Orthologs
	84557
	66734
	ENSG00000101460
	ENSMUSG00000027602
	Q9H492
	Q91VR7
	NM_032514; NM_181509
	NM_025735
	NP_115903; NP_852610
	NP_080011
	Wikidata
View/Edit Human	View/Edit Mouse

Microtubule-associated proteins 1A/1B light chain 3A is a protein that in humans is encoded by the MAP1LC3A gene.^[5]^[6]^[7] Two transcript variants encoding different isoforms have been found for this gene.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000101460 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027602 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mann SS, Hammarback JA (May 1997). "Gene localization and developmental expression of light chain 3: a common subunit of microtubule-associated protein 1A(MAP1A) and MAP1B". J Neurosci Res. 43 (5): 535–44. doi:10.1002/(SICI)1097-4547(19960301)43:5<535::AID-JNR3>3.0.CO;2-J. PMID 8833088. S2CID 23515321.
^ Pankiv S, Clausen TH, Lamark T, Brech A, Bruun JA, Outzen H, Overvatn A, Bjorkoy G, Johansen T (Aug 2007). "p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy". J Biol Chem. 282 (33): 24131–45. doi:10.1074/jbc.M702824200. PMID 17580304.
^ "Entrez Gene: MAP1LC3A microtubule-associated protein 1 light chain 3 alpha".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000101460 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027602 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8833088-5] Mann SS, Hammarback JA (May 1997). "Gene localization and developmental expression of light chain 3: a common subunit of microtubule-associated protein 1A(MAP1A) and MAP1B". J Neurosci Res. 43 (5): 535–44. doi:10.1002/(SICI)1097-4547(19960301)43:5<535::AID-JNR3>3.0.CO;2-J. PMID 8833088. S2CID 23515321.

[pmid17580304-6] Pankiv S, Clausen TH, Lamark T, Brech A, Bruun JA, Outzen H, Overvatn A, Bjorkoy G, Johansen T (Aug 2007). "p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy". J Biol Chem. 282 (33): 24131–45. doi:10.1074/jbc.M702824200. PMID 17580304.

[entrez-7] "Entrez Gene: MAP1LC3A microtubule-associated protein 1 light chain 3 alpha".

MAP1LC3A information

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